JPH034233B2 - - Google Patents
Info
- Publication number
- JPH034233B2 JPH034233B2 JP62055020A JP5502087A JPH034233B2 JP H034233 B2 JPH034233 B2 JP H034233B2 JP 62055020 A JP62055020 A JP 62055020A JP 5502087 A JP5502087 A JP 5502087A JP H034233 B2 JPH034233 B2 JP H034233B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- brush
- drug
- affected area
- porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940079593 drug Drugs 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 12
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 201000004647 tinea pedis Diseases 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 239000011148 porous material Substances 0.000 description 9
- 229920001661 Chitosan Polymers 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000007721 medicinal effect Effects 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 241000130764 Tinea Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 210000003371 toe Anatomy 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241000258241 Mantis Species 0.000 description 1
- 208000010195 Onychomycosis Diseases 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 1
- 229960003338 crotamiton Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001329 hyperkeratotic effect Effects 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 231100000405 induce cancer Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 201000005882 tinea unguium Diseases 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Brushes (AREA)
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、水虫治療用ブラシに関するもので
ある。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] This invention relates to a brush for treating athlete's foot.
水虫は白癬菌の繁殖により発生するものであ
り、足(足白癬)のほか、頻度は少ないが手(手
白癬)、爪(爪白癬)にも発生する。
Athlete's foot is caused by the proliferation of tinea fungi, and it occurs not only on the feet (tinea pedis) but also, less frequently, on the hands (tinea mantis) and nails (tinea unguium).
足白癬には、最も多い病型であつて、足の第
4指と第5指の間の第4指間に好発し他の指間や
足底に向つて拡大する趾間糜爛型、足の側縁
部、土踏まずに好発し、小水泡が発生して乾燥す
ると皮がむける小水泡・鱗屑型、最も稀な病型
であつて、かかと部分を中心に角質が増殖する角
質増殖型、の3つの病型がある。 The most common type of tinea pedis is the interdigital erosion type, which occurs most often between the fourth and fifth toes and spreads between the other toes and toward the sole of the foot. There are 3 types: the vesicular/scaling type, which occurs most frequently on the side edges and arches, and causes small blisters to peel off when dry; and the rarest type, the hyperkeratotic type, in which dead skin cells proliferate mainly on the heels. There are two types of disease.
白癬菌は、ケラチンが豊富な皮膚の最表層であ
る角質層や爪に寄生増殖し、患部から菌を含む鱗
屑がはがれて他部に感染すると考えられている。 Trichophyton is thought to grow parasitically on the stratum corneum, which is the outermost layer of the skin rich in keratin, and on the nails, and when scales containing bacteria are peeled off from the affected area, it infects other areas.
従つて、水虫を治療するには、患部をよく洗つ
て清潔にし、薬剤を一日数回塗擦しなければなら
ないとされている。 Therefore, in order to treat athlete's foot, it is said that the affected area must be thoroughly washed and cleaned, and a drug must be applied several times a day.
しかし、患部は角質層であつて鱗屑を完全に除
去するは難しいばかりか、上記の治療を毎日繰り
返すのは非常にめんどうであるため治療を怠たり
がちになり、なかなか水虫が治らない原因となつ
ていた。 However, since the affected area is made up of stratum corneum, it is not only difficult to completely remove the scales, but also because it is very troublesome to repeat the above treatment every day, people tend to neglect treatment, which is the reason why athlete's foot does not heal easily. was.
そこで、この発明を目的とするところは、患部
を完全に清潔にすると共に薬剤の塗擦を同時に行
える水虫治療用ブラシを提供することである。
SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a brush for treating athlete's foot that can completely clean the affected area and simultaneously apply a chemical.
この発明は、多糖類、タンパク質あるいはこれ
らの誘導体からなる多孔性物質を少なくともブラ
シの毛組成の一部に有し、多孔性物質には適宜薬
剤を固定してあり、この毛を少なくとも植毛の一
部に含み、植毛部の先端を尖頭状にしたものであ
る。
This invention has a porous material made of polysaccharides, proteins, or derivatives thereof as at least a part of the bristles composition of the brush, an appropriate drug is immobilized on the porous material, and the bristles are used at least as part of the hair transplantation. The tip of the hair transplanted part is pointed.
この発明は、ブラシの毛組成の少なくとも一部
に多孔性物質を有するものとし、この多孔性物質
に適宜薬剤を固定しているので、ブラシ自体に薬
効を付与することができる。従つて、患部をブラ
ツシングすることにより、患部の鱗屑、垢、汚れ
を除去すると同時に患部に薬剤を塗擦することが
できる。
In this invention, at least a part of the bristles of the brush contain a porous substance, and a drug is appropriately fixed to this porous substance, so that the brush itself can be endowed with medicinal effects. Therefore, by brushing the affected area, it is possible to remove scales, grime, and dirt from the affected area, and at the same time apply a drug to the affected area.
薬剤は多孔性物質に固定されているので、長時
間徐々に薬剤を放出することができる。 Since the drug is fixed in a porous material, it can be released gradually over a long period of time.
多孔性物質は多糖類、タンパク質あるいはこれ
らの誘導体から構成されており、これら多糖類等
は天然由来の高分子であるので高い安全性を有す
る。 The porous substance is composed of polysaccharides, proteins, or derivatives thereof, and these polysaccharides are naturally derived polymers and therefore have high safety.
また、植毛部の先端を尖頭状にしているので、
指間のような治療しにくい患部も容易にブラツシ
ングすることができる。 In addition, since the tip of the flocked part is pointed,
Even difficult-to-treat affected areas such as between the fingers can be easily brushed.
次に、この発明の一実施例を図面に基づき説明
する。
Next, one embodiment of the present invention will be described based on the drawings.
この発明に係るブラシは、多糖類、タンパク質
あるいはこれらの誘導体からなる多孔性物質をす
くなくとも毛組成の一部に有し、多孔性物質には
適宜薬剤を固定してあり、この毛を少なくとも植
毛の一部に含み、植毛部の先端を尖頭状にしたも
のである。 The brush according to the present invention has at least a part of the bristles composed of a porous substance made of polysaccharides, proteins, or derivatives thereof, a suitable drug is immobilized on the porous substance, and the bristles are at least used for hair transplantation. The tip of the hair transplanted part is pointed.
この発明における多糖類としては、キチン、キ
トサン、セルロース、デキストラン、アガロー
ス、デンプン等の一種あるいは二種が好ましい。
特に、キトサンやジヤガイモデンプン由来の多孔
性物質は有効である。これらの誘導体としては、
例えばこれらのイオン交換性の誘導体、疎水性基
をもつ誘導体、タンニンを結合させた誘導体であ
る。 The polysaccharide used in this invention is preferably one or two of chitin, chitosan, cellulose, dextran, agarose, starch, and the like.
In particular, porous materials derived from chitosan and ginger starch are effective. These derivatives include:
Examples include ion-exchangeable derivatives of these, derivatives with hydrophobic groups, and derivatives to which tannins are bonded.
この発明におけるタンパク質としては、グルテ
ン、絹糸等である。 Proteins in this invention include gluten, silk thread, and the like.
多糖類あるいはその誘導体から多孔性物質を製
造するには、例えばキトサンでは低分子量キトサ
ンを酸性溶液に溶解し、この溶解液を塩基性溶液
中に落下して凝固粒状化している。このようにし
て得られた粒状多孔性キトサンは、粒度が揃つて
おり、均一な微細孔を有し比表面積が大きいの
で、各種薬剤の固定化能が高い。 To produce a porous substance from a polysaccharide or its derivative, for example, chitosan is produced by dissolving low molecular weight chitosan in an acidic solution, and dropping this solution into a basic solution to coagulate it into granules. The granular porous chitosan thus obtained has uniform particle size, uniform micropores, and a large specific surface area, so it has a high ability to immobilize various drugs.
このような多孔性物質を少なくとも毛組成の一
部に有する毛を製造するには、多孔性物質(例え
ば上記粒状多孔性キトサンでは粒径1〜15μm、
比表面積2〜5m2/gのもの)のみあるいはナイ
ロン等の合成樹脂との混合物を成形機から糸状に
押し出し、25μm程度の線径にする。 In order to produce hair having such a porous material as at least a part of the hair composition, it is necessary to use a porous material (for example, in the above-mentioned granular porous chitosan, the particle size is 1 to 15 μm,
A material having a specific surface area of 2 to 5 m 2 /g) alone or a mixture with a synthetic resin such as nylon is extruded into a thread form from a molding machine, and the wire diameter is about 25 μm.
次に、このようにして製造した刷毛に薬剤を含
浸させ、多孔性物質に薬剤を固定させる。薬剤と
しては、ピロールニトリン、クロタミトン、サリ
チル酸、塩化ベンザルコニウムやイミダゾール系
薬剤等である。固定手段としては、物理吸着や官
能基(アミノ基、カルボキシル基、水酸基、イミ
ダゾール基、フエノール基、スルフヒドリル基
等)による共有結合である。 Next, the brush thus produced is impregnated with a drug, and the drug is fixed in the porous material. Examples of drugs include pyrrolenitrine, crotamiton, salicylic acid, benzalkonium chloride, and imidazole drugs. Immobilization means include physical adsorption and covalent bonding by functional groups (amino group, carboxyl group, hydroxyl group, imidazole group, phenol group, sulfhydryl group, etc.).
このようにして薬効を付与した毛をブラシの本
体1に植毛する。ブラシは、第1図乃至第3図に
示すように、本体1の先端と植毛部2の先端を尖
頭状に形成してあり、第1図と第2図は一側辺1
aのみを斜傾させたものであり、第3図は両側辺
1a,1bを斜傾させたものである。植毛に当つ
ては、上記毛のみを使用するほか、ナイロン等の
合成毛や、豚毛、白馬毛のような天然毛を加えて
混毛にしてもよい。 The bristles imparted with medicinal properties in this manner are implanted into the main body 1 of the brush. As shown in FIGS. 1 to 3, the brush has the tip of the main body 1 and the tip of the bristle part 2 shaped like a point, and FIGS. 1 and 2 show one side 1.
Only the side 1a and 1b in FIG. 3 are tilted. For hair transplantation, in addition to using only the above-mentioned hair, synthetic hair such as nylon or natural hair such as pig hair or white horse hair may be added to create a mixed hair.
以上のように構成されたブラシは、患部をブラ
ツシングすることにより、患部の鱗屑、垢、汚れ
を除去すると同時に患部を塗擦する。ブラツシン
グ中に薬剤が多孔性物質から分離放出されるの
で、長時間安定した薬効を持続する。また、多孔
性物質には、多糖類等の天然由来の高分子を使用
しているので、がんを誘発したり、炎症やアレル
ギーを引き起すことはない。また、患部が指間の
ように治療しにくいところであつても、植毛部の
先端を尖頭状にしているので、容易にブラツシン
グすることができる。 By brushing the affected area, the brush configured as described above removes scales, dirt, and dirt from the affected area, and at the same time rubs the affected area. Since the drug is separated and released from the porous material during brushing, stable drug efficacy is maintained for a long time. Furthermore, since the porous material uses naturally derived polymers such as polysaccharides, it does not induce cancer, inflammation, or allergies. Furthermore, even if the affected area is difficult to treat, such as between the fingers, the tip of the hair transplanted part is pointed, so it can be easily brushed.
この発明は、多孔性物質を少なくともブラシの
毛組成の一部に有し、多孔性物質に薬剤を固定し
ているので、ブラツシングするだけで患部を完全
に清潔にすることと薬剤の塗擦を同時に行うこと
ができる。従つて、治療は簡単であるにも拘らず
治療効果は大きい。
This invention has a porous substance in at least a part of the bristles of the brush, and the drug is fixed to the porous substance, so that just by brushing, you can completely clean the affected area and apply the drug at the same time. It can be carried out. Therefore, although the treatment is simple, it is highly effective.
また、多糖類、タンパク質あるいはこれらの誘
導体からなる多孔性物質を使用しているので、歯
ブラシは薬効に持続性を有すると共に安全性が高
い。 Furthermore, since the toothbrush uses a porous substance made of polysaccharide, protein, or a derivative thereof, the toothbrush has long-lasting medicinal effects and is highly safe.
また、植毛部の先端を尖頭状にしているので、
治療しにくい患部をも簡単に治療することができ
る。 In addition, since the tip of the flocked part is pointed,
Even difficult-to-treat affected areas can be easily treated.
第1図乃至第3図はこの発明の実施例を示す図
面。第1図はこの発明に係るブラシの斜視図。第
2図は同平面図。第3図は他の実施例を示す平面
図。
1……本体、2……植毛部、1a,1b……側
辺。
1 to 3 are drawings showing embodiments of the present invention. FIG. 1 is a perspective view of a brush according to the present invention. Figure 2 is a plan view of the same. FIG. 3 is a plan view showing another embodiment. 1... Main body, 2... Flocked portion, 1a, 1b... Side sides.
Claims (1)
からなる多孔性物質を少なくとも毛組成の一部に
有し、多孔性物質には適宜薬剤を固定してあり、
この毛を少なくとも植毛の一部に含み、植毛部の
先端を尖頭状にしていることを特徴とする水虫治
療用ブラシ。1. At least a part of the hair composition includes a porous substance made of polysaccharide, protein, or a derivative thereof, and an appropriate drug is immobilized on the porous substance,
A brush for treating athlete's foot, characterized in that this hair is contained in at least a part of the flocked hair, and the tip of the flocked part is pointed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62055020A JPS63220880A (en) | 1987-03-10 | 1987-03-10 | Brush for treating dermatophytosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62055020A JPS63220880A (en) | 1987-03-10 | 1987-03-10 | Brush for treating dermatophytosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63220880A JPS63220880A (en) | 1988-09-14 |
| JPH034233B2 true JPH034233B2 (en) | 1991-01-22 |
Family
ID=12986983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62055020A Granted JPS63220880A (en) | 1987-03-10 | 1987-03-10 | Brush for treating dermatophytosis |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63220880A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0755892Y2 (en) * | 1993-03-25 | 1995-12-25 | 株式会社荒木製作所 | Pet brush |
-
1987
- 1987-03-10 JP JP62055020A patent/JPS63220880A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63220880A (en) | 1988-09-14 |
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