JPH0645531B2 - External skin preparation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to 4- (1,1-dimethylethyl) -4′-methoxydibenzoylmethane together with a carbon number of 9 to 31.
By blending a monovalent alcohol having a straight chain, branched chain or unsaturated alkyl residue with a monovalent ester of an acid having a straight chain, branched chain or unsaturated alkyl residue having 9 to 31 carbon atoms. The present invention relates to a skin external preparation having an ultraviolet protection effect and excellent quality.

[Prior Art] It is known that sun rays not only cause sunburn but also promote skin aging due to the sunburn.

There are not a few skin external preparations designed to prevent the sun's rays, but all of them are powdered and mainly reflected,
It was dealt with by scattering, or was compounded with substances called UV-B such as salicylic acid derivatives and aminobenzoic acid derivatives that absorb only ultraviolet rays having a relatively short wavelength.

[Problems to be Solved by the Invention] 4- (1,1-Dimethylethyl) -4′-methoxydibenzoylmethane is a harmful U to sun rays, especially to the skin.
Recently, it has been spotlighted as a substance called VA that absorbs ultraviolet rays having a relatively long wavelength, but its compatibility with the skin external preparation base is poor, and it is relatively short even if it is mixed with the skin external preparation in a dissolved state. It often precipitates as crystals over time.

Needless to say, when the crystals are deposited as crystals, the quality of the external preparation for skin is significantly impaired, and even the UV absorption ability for the original purpose cannot be exhibited.

[Means for Solving Problems] As a result of earnest research in view of such circumstances, the present inventor has found that 4- (1,
1-Dimethylethyl) -4'-methoxydibenzoylmethane together with a monohydric alcohol having a C9-C31 straight-chain, branched, or unsaturated alkyl residue and a C9-C31 straight-chain, branched, C1-C3 It has been found that by adding a monovalent ester with an acid having a saturated alkyl residue, it is possible to obtain an external preparation for skin which is excellent in ultraviolet absorbing effect and is excellent in stability for a long period of time and does not easily deteriorate in quality. The invention was completed.

That is, the present invention provides a skin external preparation having an excellent ultraviolet absorbing effect and an excellent quality.

Hereinafter, the configuration of the present invention will be described in detail.

4- (1,1-dimethylethyl) -used in the present invention
4'-methoxydibenzoylmethane is disclosed in JP-A-55-6.
It is manufactured by the method shown in 6535, and is supplied by Givaudan Co., Ltd. under the trade name of "Pulsol 1789".

The amount to be added to the external preparation for skin is largely arbitrary depending on the expected UV absorption effect, but if the amount is extremely large, the base of the external preparation for skin becomes too small, which is not preferable. It is preferably 0.01 to 10%. If it is less than 0.01%, the ultraviolet absorbing effect is small and the intended purpose cannot be achieved. If it exceeds 10%, the amount of the base for external skin application is reduced and the quality of the external skin preparation itself is impaired.

Further, the number of carbon atoms to be blended for the purpose of exerting the effect of the present invention is 9
1 to having 1 to 31 straight chain, branched chain, unsaturated alkyl residues
Examples of the monovalent ester of a divalent alcohol and an acid having a linear, branched or unsaturated alkyl residue having 9 to 31 carbon atoms include 2-hexyldecyl myristate and 2-octyldodecyl-2'-isoheptyl. Synthetic oils such as isoundecanoate, oleyl oleate, 2-heptylundecyl palmitate, or vegetable oil jojoba oil,
Deep sea fish oil such as orange luffy oil and natural oils such as beeswax are included. One or more of these esters are blended, but the amount blended for the purpose of exerting the effect of the present invention is 4-
The amount of (1,1-dimethylethyl) -4'-methoxydibenzoylmethane is required to be 1/2 or more, and even if it is added in excess, the effect of the present invention is not impaired.

In the present invention, 4- (1,1-dimethylethyl) -4 '
-Methoxydibenzoylmethane and a monohydric alcohol having a linear, branched or unsaturated alkyl residue having 9 to 31 carbon atoms and an acid having a linear, branched or unsaturated alkyl residue having a carbon atom of 9 to 31 As the skin external preparation base to which the monovalent ester is added, any ordinary skin external preparation base can be used.

That is, liquids, gels, pastes, creams and the like, as a component for modifying the skin external preparation, moisturizers, oils, surfactants, thickeners, sequestering agents, other ultraviolet absorbers, drugs, It goes without saying that dyes and fragrances can be used in combination.

[Examples] <Example 1> Sunscreen oil 4- (1,1-dimethylethyl) 2wt% -4'-methoxydibenzoyl methane glyceryl monooleate 2 jojoba oil 20 liquid paraffin 76 [Effect of the invention] Example 1 Is 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane in accordance with the present invention, a monovalent alcohol having a linear, branched or unsaturated alkyl residue having 9 to 31 carbon atoms and a carbon number. A skin external preparation containing a monovalent ester of an acid having a linear, branched or unsaturated alkyl residue of 9 to 31.

On the other hand, the case where 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane is not mixed and the case where ester is not mixed are shown below as control examples.

<Control Example 1> 4- (1,1-dimethylethyl) 2 wt% -4'-methoxydibenzoyl methane glyceryl monooleate 2 liquid paraffin 96 <Control Example 2> glyceryl monooleate 2 wt% jojoba oil 20 liquid paraffin 78 Table 1 Shows storage stability and UV protection effect.

The external preparations for skin of Example 1 and Comparative Examples 1 and 2 are all used as sunscreen oils.

Although Comparative Example 1 was a uniform liquid immediately after the production, 4-
(1,1-Dimethylethyl) -4'-methoxydibenzoylmethane is gradually deposited, and the quality of the external skin preparation is deteriorated, and even the ultraviolet protection effect is reduced.

In Comparative Example 2, crystals are not precipitated, but the UV protection effect cannot be expected.

On the other hand, in Example 1, the crystals are not precipitated immediately after the production and also after the storage for a long period of time, the ultraviolet protection effect is excellent, and the quality is stable.

This is a result of applying the technique according to the present invention.

Next, the present invention will be described in detail with reference to a number of examples, but the present invention is not limited thereto.

Example 2 Example 2 A. Cetanol 3 wt% Glyceryl monostearate 2 Stearic acid 3 Vaseline 3 Jojoba oil 3 2-Hexyldecyl myristate 4 Squalane 5 4- (1,1-Dimethylethyl) 2 -4'-methoxydibenzoyl methane fragrance Amount B. Propylene glycol 3 Potassium hydroxide 0.2 Purified water based on the total amount of 100 An oil phase portion of A and an aqueous phase portion of B are dissolved by heating at 70 ° C., and A is added to B to emulsify. Then, it is cooled to obtain a cream.

Example 4 A. Stearyl alcohol 2 wt% glyceryl monostearate 2 POE (50) oleyl ether 2 stearic acid 2 purified lanolin 2 2-heptylundecyl 2 palmitate 2-octyldodecyl-2'-5 isoheptylisoundecanoate 4- (1,1 -Dimethylethyl) 2-4'-methoquindibenzoyl methane Preservative Amount Perfume Amount B. Glycerin 5 Potassium hydroxide 0.2 Purified water 100 as a whole C.I. Formulated powder 10 A oil phase raw material and B aqueous phase raw material are heated and melted at 70 ° C., respectively, and then A is added to B and emulsified. A powdery portion of C is dispersed therein and then cooled to obtain a cream foundation.

Example 5 Orange lafa oil 50 wt% jojoba oil 30 Liquid paraffin 10 4- (1,1-Dimethylethyl) 10-4'-methoxydibenzoyl methane Dye Appropriate amount Perfume Appropriate amount The above components are heated and dissolved at 50 ° C. and then stirred. Cool and get body oil.

Example 6 Solid paraffin 10 wt% Liquid paraffin Amount based on the total amount of 100 Vaseline 20 Glyceryl monomyristate 10 Oleyl oleate 0.05 4- (1,1-Dimethylethyl) 0.1 -4'-methoxydibenzoyl methane dye Appropriate amount Fragrance Suitable amount Each of the above components is heated and dissolved at 50 ° C., and then stirred and cooled to obtain a gel for body.

The external preparations for skin of Examples 2 to 6 were excellent in the effect of absorbing ultraviolet rays, and there was no deterioration in quality due to precipitation of crystals even after 3 months from the production.

This is a result of applying the technique according to the present invention.

Claims (1)

[Claims] 1. 4- (1,1-Dimethylethyl) -4'-
Along with methoxydibenzoylmethane, a monohydric alcohol having a straight-chain, branched, unsaturated alkyl residue having 9 to 31 carbon atoms and an acid having a straight-chain, branched, unsaturated alkyl residue having 9 to 31 carbon atoms A skin external preparation characterized by containing a monovalent ester.