JPH0750095B2 - Continuous manufacturing equipment for chemical analysis slides - Google Patents

Description

The present invention relates to an apparatus for continuously producing a chemical analysis slide for chemically analyzing and measuring a liquid sample.

(Prior Art) In recent years, glucose, bilirubin, urea, etc. contained in a sample solution can be simply supplied by spot-dropping a sample solution such as body fluid.
A dry type chemical analysis slide capable of quantitatively analyzing a chemical component such as nitrogen or a formed component has been developed and put into practical use (Japanese Patent Publication No. 53-21677, Japanese Patent Publication No. 55-164356, etc.). In order to analyze the chemical components in the sample solution using such a chemical analysis slide, a small amount of the sample solution is weighed and attached on the chemical analysis film of the chemical analysis slide, and this is then placed in an incubator (incubator). Incubation at a constant temperature for a predetermined time to cause a color reaction (dye formation reaction), and at this time irradiation for measurement that includes a wavelength preselected by the combination of the sample components and the reagents contained in the reagent layer of the chemical analysis film This chemical analysis slide is irradiated with light to measure its reflection optical density.
Quantitative analysis of the above chemical components etc. is performed.

The chemical analysis slide 5 is, for example, as shown in FIG. 16, a mount base 1 made of a rectangular plastic sheet having a through hole 1a for measuring the concentration due to a color reaction in the chemical analysis film, A mount frame 2 made of a rectangular plastic sheet having a holding hole 2a larger than the through hole 1a for securing a space for loading a chemical analysis film, and a point for spotting a liquid sample such as body fluid. It is composed of a mount cover 3 made of a rectangular plastic sheet having a hole 3a and a chemical analysis film 4 held in the holding hole 2a. The chemical analysis film 4 was put in the holding hole 2a. In this state, the mount frame 2 is sandwiched between the mount base 1 and the mount cover 3 from above and below to be bonded together.

Since the production efficiency is not good if the above chemical analysis slides are made one by one, a method of continuously producing this chemical analysis slide is also considered, and as this continuous production method, a roll is used. Using a plurality of long plastic strip-shaped sheets that are wound, each sheet that is supplied and sent from each roll is sequentially punched with a through hole 1a, a holding hole 2a, and a spotting hole 3a, and inside the holding hole 2a. After the chemical analysis film 4 is held on the upper and lower sides of the strip-shaped sheets, the chemical analysis slide having the above-mentioned structure is continuously manufactured by punching this sheet into a predetermined shape and sandwiching the chemical analysis film therebetween. Things were common. However, in this case, when the strip-shaped sheet is processed in a long period from being supplied from the roll to being taken out as a product, and a long strip-shaped sheet is stretched or meandered, the sheet should be punched into the sheet. However, there have been drawbacks such that the sheets are bonded together with the center positions of the through hole 1a, the holding hole 2a, and the spotting hole 3a shifted, or the chemical analysis slide is warped when it is made into a product.

(Problems to be Solved by the Invention) As a method for solving such a drawback, one in which one or several plastic sheets are preliminarily punched and a chemical analysis film is mounted is disclosed in JP-A-61-51570. As disclosed in the official gazette, in this case, it is necessary to intermittently handle the sheet materials once punched, one by one, as compared with the case where the above-mentioned strip-shaped sheet is used for manufacturing. However, there are still some problems such as that it becomes complicated and it is difficult to increase the manufacturing speed.

(Means for Solving Problems) The present invention has been made in view of the problems such as the deviation of the hole position of each sheet and the warp of the product caused by the elongation and meandering of the strip-shaped long sheet in the conventional continuous production described above. Provide a device with a relatively simple structure so that even if stretched and meandering occurs in the belt-like sheet, it can be absorbed to prevent the displacement of the hole position and the product warp and continuously manufacture chemical analysis slides. In order to solve the above problem, the manufacturing apparatus of the present invention is configured as follows.

That is, this manufacturing apparatus stacks a plurality of strip-shaped plastic sheets having slits extending in the axial direction and positioning holes respectively located between the slits at regular intervals in the longitudinal direction, and stacks the sheets in the longitudinal direction. Sheet conveying means, a film arranging means for sequentially holding the chemical analysis film between the strip-shaped plastic sheets conveyed by the sheet conveying means at a predetermined interval, and a strip-shaped plastic which holds the chemical analysis film and is vertically stacked. In the portion surrounding each of the chemical analysis films, the sheet-making sheet is joined to the sheet-conveying means to form a belt-shaped polymerized sheet by sequentially adhering to each other in accordance with the conveyance by the sheet-conveying means, and the belt-shaped polymerized sheet is conveyed by the sheet-conveying means. Punching hand to punch each peripheral part of the chemical analysis film according to And a positioning pin to be inserted into each of the positioning holes so as to position each part of the strip-shaped plastic sheet before the bonding operation of the strip-shaped plastic sheet or the punching operation of the chemical analysis film is performed. ing.

(Operation) When the above-described manufacturing apparatus is used, a plurality of strip-shaped plastic sheets are vertically stacked by the sheet conveying means and conveyed in the longitudinal direction, and the film arranging means forms a chemical gap at a predetermined interval between the conveyed sheets. Hold the analysis film, and then bond the sheets sandwiching each chemical analysis film to the top and bottom to form a belt-shaped polymerized sheet.The belt-shaped polymerized sheet is sequentially punched by a punching means in the peripheral portion of each chemical analysis film. The continuous production of chemical analysis slides is made by pulling out.

Then, by inserting positioning pins into the positioning holes provided in advance between the respective slits before the bonding or punching work is performed, the respective parts of the sheet are positioned. The effect of preventing the sheet misalignment is ensured by absorbing the strain generated between the respective portions of the sheet in the slit.

(Examples) Hereinafter, preferred examples of the present invention will be described with reference to the drawings.

FIG. 1 is a perspective view schematically showing a step of continuously producing a chemical analysis slide by the production apparatus of the present invention.
Reference numerals 11, 12 and 13 are strip-shaped long plastic sheets for forming a mount base, a mount frame and a mount cover, respectively, and are supplied by being wound into a roll or the like. Therefore, the first sheet 11 for forming the mount base has a plurality of through holes 1a, and the second sheet 12 for forming the mount frame has a plurality of holding holes 2a.
However, a plurality of spotting holes 3a are respectively formed in the third sheet 13 for forming the mount cover, and the portions surrounded by the two-dot chain line in the figure surrounding the plurality of holes are formed after bonding. Punched to form a chemical analysis slide. These plastic sheets 11, 12, 13 are intermittently conveyed at a constant interval on the conveying path by means such as a conveying pin method which is the conveying method of the present invention. In this case, each of the sheets 11, 12 and 13 is formed by a set of four mounting members that are connected in a strip shape, and between each pair, from both ends toward the center side. A slit group consisting of a pair of slits 11a, 12a, 13a extending in the width direction and slits 11a, 12a, 13a extending in the width direction in the central portion is formed. That is, four chemical analysis slides are integrally provided between each slit group, and this slit group allows positional deviation between each pair during conveyance,
It absorbs the elongation of the sheets 11, 12 and 13 and prevents the sheet from meandering. In addition, a pair of positioning holes 11b, 12b, 13b located near both ends as shown in the figure are formed in the vicinity of each slit group, and positioning pins are inserted into these positioning holes to bond the sheets 11, 12, 13 together. Positioning is performed in the case of punching a sheet or a sheet that has been attached, and transport holes 11c, 12c, 13c into which transport pins are inserted are formed in the central portion. The chemical analysis film 4 is obtained by cutting a long strip film 14 having a predetermined width, which is wound in a roll shape, into a predetermined length.

A method for continuously producing a chemical analysis slide using the above sheets 11, 12, 13 and the strip film 14 will be described.
First, the second sheet 12 is superposed on the first sheet 11 and conveyed on the conveying path, and the through holes 1a of the first sheet 11 and the holding holes 2a of the second sheet 12 are aligned with each other so that both sheets 11, 12 Stick on top and bottom. At this time, a transport pin (not shown) is inserted into the transport holes 11c and 12c, and both sheets are set for each set by the transport pin.
The sheets 11 and 12 are conveyed in a stacked state by performing the vertical alignment of 11 and 12 and moving the conveying pin in the conveying direction. Then, in the state where the above-mentioned bonding is performed, the transport pin is pulled out from the transport hole, and a positioning pin (not shown) is inserted into the positioning holes 11b and 12b.
After performing the accurate vertical alignment for each group, the sheets 11 and 12 are bonded together by bonding with an adhesive material, ultrasonic welding, or the like. By this bonding, chemical analysis film 4
Space for filling (holding hole formed in the second sheet 12)
A long sheet having 2a is formed.

The sheet thus laminated is further conveyed on the conveying path by the conveying pin inserted into the conveying hole again, and the chemical analysis film obtained by cutting the strip-shaped film 14 wound into a roll into a predetermined size. 4 is filled by the means such as pick and place into the space (holding hole 2a. After that, the third sheet 13 is superposed and conveyed, and the third sheet 13 is further adhered and ultrasonic waves are applied. A band-shaped sheet 15 having a plurality of chemical analysis slides loaded with a chemical analysis film between them is made by pasting by gluing, etc. The band-shaped sheet 15 is punched out along a line indicated by a chain double-dashed line in the figure, A plurality of chemical analysis slides 5 are continuously manufactured, the third sheet 13 being attached,
Positioning holes 11b, 12b, 13 are also provided when the chemical analysis film is loaded into the holding hole 2a and the chemical analysis slide 5 is punched out.
A positioning pin is inserted in b for accurate positioning. In this case, each slit group absorbs the elongation and meandering of the belt-like sheet, whereby the positioning pin is accurately aligned, and the vertical position of each hole 1a, 2a, 3a occurs, or the punching is performed. The subsequent chemical analysis slide is prevented from being warped. The remaining portion 6 left after punching the chemical analysis slide 5 having the slit group, the positioning holes, the feed holes, etc., is cut to an appropriate length and then discarded.

The chemical analysis slides are continuously manufactured by laminating the sheets 11, 12, and 13 through the steps as described above. The apparatus for this manufacture is described with reference to FIGS. 2 and 3. Explain. 2 and 3 are a front view and a plan view of an apparatus for continuously producing the chemical analysis slide.

This device is the first to third sheets from left to right in the figure.
It has the 1st conveyance path 25 which conveys 11,12,13, and the 1st-3rd sheets 11,12 for supplying the 1st-3rd sheets 11,12,13 on this conveyance path 25. The first to third reels 21, 22, and 23, on which the reels 13 and 13 are wound, are arranged above the transport path 25 in order from the left as illustrated. The first ultrasonic welder 51 is arranged between the second reel 22 and the third reel 23, and therefore, the first sheet 11 of the first sheet 11 sent out from the first reel 21 onto the first transport path 25 is disposed. The second sheet 12 sent out from the second reel 22 above
When the sheets 11 and 12 are conveyed on the first conveying path 25 and positioned below the first ultrasonic welding device 51 after being stacked, the sheets 11 and 12 are ultrasonically welded for each set between the slit groups. Pasted together.

After that, the film 4 is loaded into the holding hole 2a of the second sheet 12, and the loading of the film 4 is performed by simultaneously loading four films aligned in each set. This will be described with reference to FIGS. 4A and 4B together. The chemical analysis film is wound around the fourth reel 31 in the form of a belt-shaped sheet 14. This fourth reel
The sheet 14 delivered from the sheet 31 is first inspected by the sample inspector 32. This inspection detects a defective portion to which a check mark is previously attached by the inspection at the time of manufacturing the filter, and thus, a defective (NG) portion of the film can be detected. Then, the strip-shaped film 14 is cut into a predetermined length by the cutter 33, and the chemical analysis film 4 having a predetermined size is produced. This film 4 is transferred to the pallet 41 of the pallet conveyor 40 by the high speed transfer means 100.
It is placed on the top and conveyed by this pallet 41.

The high speed transfer means 100 includes a bearing 1 fixed to a base 103, as shown in detail in FIGS. 4A and 4B.
A rotary shaft 101 is attached to 02 so as to be rotatable and slidable up and down.
A rotating arm 110 having four arms 111 to 114 extending at an angle of 0 degree is fixed. Each arm 111-114
Suckers 111a to 114a are attached to the lower part of the tip of the. One end of suction hoses 121 to 124 made of a flexible material for negative pressure supply is connected to the upper end of the rotary shaft 101, and the other end is connected to a negative pressure supply source 120 (FIG. 5). Therefore, the rotating shaft 1
The suction hose 1 from the negative pressure supply source 120 through the communication holes 111b to 114b provided inside 01 and inside each arm 111 to 114.
The negative pressure applied to 21-124 is supplied to each suction cup 111a-114a. A circumferential groove 101b is formed in the lower part of the rotating shaft 101, and the vertical movement link 106 is formed in the groove 101b.
The tip of is fitted. The link 106 is swung by the first rod 107 about the support shaft 106b, and the tip 106a is vertically moved by this swing, and the rotary shaft 101 is also vertically moved.
Further, a rotatable connecting body 104 is attached to the lower part of the bearing 102, and a pin 104a extends downward from the connecting body 104, and the pin 104a is a supporting body 101 fixed to the rotating shaft 101.
It is fitted in c so that it can move up and down. Therefore, when the connecting body 104 is rotated by the second rod 105 connected to the connecting body 104, this rotation is performed via the pin 104a and the support body 101c.
The rotation shaft 101 is rotated.

The operation of the high-speed transfer means 100 having the above structure will be described. Below the suction cups 111a to 114a at the tips of the arms 111 to 114, as shown in FIG. 4A, a first cradle 11 for receiving the films 4 cut and sent by the cutter 33 one by one.
5 and on the rotation locus of the suction cup with respect to this pedestal 115
The second and third pedestals 116 arranged at an angle of 90 degrees,
117 and a pallet 41 acting as a fourth cradle 180 degrees away from the first cradle 115. Therefore, first, the first rod 107 is used to rotate the rotary shaft 101 together with the rotary arm.
When 110 is moved downward, the suction cups 111a and 112a at the tips of the first arm 111 and the second arm 112 come into contact with the film 4 on the first pedestal 115 and the second pedestal 116 and hold them by suction.
Then, the rotating arm 110 is moved upward and rotated counterclockwise by 90 degrees, and the films 4 sucked and held by the suction cups 111a and 112a at the tips of the first and second arms 111 and 112 are respectively in the second cradle. 116 and the first receiving portion 41a of the pallet 41
Of the film 4 and the rotating arm 110 is moved downward to move the films 4 into the second pedestal 116 and the pallet 41.
It is placed on the first receiving portion 41a. At this time, at the same time, the third and fourth arms 113, 114 are moved from the positions above the pallet 41 and the third pedestal 117 to the positions above the third pedestal 117 and the first pedestal 115, respectively, and the pivoting arm 110.
The suction cups 113a, 11 at the tip of each arm 113, 114
4a is the film 4 on the third pedestal 117 and the first pedestal 115
The film 4 sent above is brought into contact with and held by suction. After this, the rotating arm 110 is moved upward and is rotated 90 degrees in the opposite direction to the above case, that is, clockwise, and is moved downward to move the suction cups 1 at the tips of the third and fourth arms 113, 114.
The film 4 sucked and held by 13a and 114a is the pallet
It is conveyed to 41 and the third receiving tray 117. Thereafter, the vertical movement of the rotating arm 110 and the reciprocating rotation of 90 degrees are continuously performed as described above, and the film 4 sequentially sent to the first receiving stand 115 is the tip of each of the arms 111 to 114. The sucker 113a
~ 114a is suction-held and conveyed one by one on the pallet 41 every time the rotating arm 110 rotates. The rotating arm 110
Is a 90-degree reciprocating rotation, so suction hose 121
.. to 124 are made of a flexible material, and the rotation is absorbed by the twist of the hose, the fixed negative pressure source 120 and the rotating shaft 101 to be rotated are connected to the hose 121.
To 124, it is easy to connect them, and a rotary joint or the like which is conventionally required for connecting the rotating member and the fixed member is unnecessary, and the structure thereof is simplified.
When the rotating arm 110 is rotated, the film including the defective portion detected by the sample inspector 32 is removed by releasing the suction or abutting the removing member protruding on the rotating trajectory. So that it cannot be sent to the pallet 41.

In this case, the pallet 41 can be transported on the transport path 42 in the direction indicated by the arrow B in the figure, and first and second moving means 46, 46 for moving the pallet 41 in the directions A and C on both sides. Are arranged, and the pallet 41 is moved along the following predetermined path in response to the rotation of the rotating arm 110. That is, in the state shown in FIG. 4A, the pallet 41 receives the film 4 conveyed by the rotation of the rotating arm 110 on the first receiving portion 41a, and then the first moving means 4
The second receiving portion 41b is pushed by 6 in the direction of the arrow A so that the second receiving portion 41b is positioned on the rotation track of the suction cup, and the film 4 conveyed by the next rotation of the rotating arm 110 is received by the second receiving portion 41b. Then, the pallet 41 is moved in the direction of the arrow B on the conveying path 42, and the film 4 conveyed by the next rotation of the rotating arm 110 is received by the third receiving portion 41c, and finally the second moving means 47. Is pushed in the direction of arrow C by the fourth receiving portion 41.
The film 4 conveyed by the rotating arm 110 is received in d. In this way, by moving the pallet 41, which acts as the fourth cradle corresponding to the rotation of the rotating arm 110, along the predetermined path indicated by the arrows A, B, and C, the rotating arm is moved.
The films 4 conveyed one by one by the reciprocating rotation of 110 can be arranged and placed on the pallet 41 in a predetermined pattern.

In the above, the film 4 is moved by the rotating arm 110.
Although an example in which they are conveyed one by one to the pallet 41 is shown, instead of this rotating arm, as shown in FIG. 4C, first and second arms 111 and 112 each having one suction cup and two suction cups each are provided. Using a pivot arm 110 'having a third and a fourth arm 113', 114 'having a second and a third cradle 116', 117 '
It is also possible to use a high-speed transfer means 100 'capable of mounting two films 4 each. In this case, the first and second arms 111, 112 allow the first cradle 115 to
The films 4 sent to the second and third receiving trays 116 'and 117' are conveyed one by one to the second and third receiving trays, and these second and third receiving trays are conveyed along with the rotation of the rotating arm 110 '. In the direction of the arrow D, two films are aligned and placed, and the two films 4 are simultaneously suctioned and held by the two suction cups of the third and fourth arms 113 'and 114'. And is conveyed to the pallet 41. For this reason, pallet 41
Is moved in the direction of the arrow B on the transport path 42,
The film 4 can be aligned and placed on 41a to 41d.

When the films 4 are aligned and placed on the pallet 41 as described above, the pallet 41 is transferred to the pallet transport unit 40 shown in FIG.
Is transported over. The pallet transport unit 40 has a pallet transport path 42 forming a rectangular loop, and a plurality of pallets 41 are placed on a conveyor which is provided in the pallet transport path 42 and driven by drive motors 44a to 44d. The pallets 41 are conveyed on the pallet conveyance path 42 in the clockwise direction in the figure. Therefore, when each chemical analysis film 4 is placed by the high-speed transfer means 100 in the four receiving portions 41a of the pallet 41 as described above, the pallet 41
Is conveyed clockwise on the conveying path 42 as indicated by the arrow,
It is stopped by the stopper 45a and positioned at the E position. Above this E position, there are four suction cups attached to the tip of a sample transfer arm 43 rotatable about a shaft 43a as shown by an arrow P, and the pallet 41 at the E position is located.
The four films 4 placed on are the suction cups 43 of the arm 43.
Adsorbed on b. The arm 43 rotates about the shaft 43a to the position shown by the broken line in the figure, and the suction cup 43b at the tip is positioned on the first and second sheets 11 and 12 conveyed on the conveyance path 25. Then, the arm 43 is moved downward and the four films 4 adsorbed on the suction cups 43b are held in four holding holes of the second sheet 12.
It is loaded in 2a. The pallet 41 is a pallet transport path.
42 is sent in the direction of the arrow and returned to the original position.

When the chemical analysis film 4 is loaded into the holding holes 2a of the first and second sheets 11 and 12 bonded by the first ultrasonic welding device 51 as described above, this sheet is fed to the first transport path 25. Further conveyed, the third sheet 13 wound on the third reel is stacked on the first and second sheets 11 and 12. When the first to third sheets 11, 12, and 13 are vertically positioned below the second ultrasonic welding device 53, the welding device 53 holds the three sheets 11, 12, and 13 in the holding holes. While holding the film 4 in 2a, it is welded and bonded around the holding hole 2a, and four chemical analysis slides are integrally formed between each slit group to form one set. A band-shaped polymerized sheet 15 in which the sets are continuously connected in a band shape through slit groups is obtained.

This sheet is further fed on the first transport path 25 to the left in FIG. 2 and positioned below the film thickness tester 70, the details of which are shown in FIG. Film thickness tester 70
Is an apparatus for inspecting the misalignment of the film by inspecting the thickness of each set of the chemical analysis slides integrally connected. This inspection device 70 includes a base 74 on which the belt-shaped overlapping sheet 15 is placed, a main body 71 which is integrally formed with the base 74 and is located above the belt-like overlapping sheet 15, and a shaft which is vertically movable with respect to the main body 71. 72 and a measuring head 73 attached to the lower end of the shaft 72, and the belt-shaped polymerized sheet 15 is held between the base 74 and the measuring head 73 according to the vertical movement of the shaft 72, and the belt-shaped polymerized sheet 15 is held. It is designed to measure 15 thicknesses. This measurement thickness is the gauge of the main body 71
Displayed on 71a. The strip-shaped polymer sheet 15 has a cross section of the seventh
As shown in FIG. A, a first plastic sheet (lower sheet) 11 having a through hole 1a and a holding hole 2a are provided.
The second plastic sheet (intermediate sheet) 12 having the chemical analysis film 4 loaded therein and the third plastic sheet 13 having the spotting holes 3a are polymerized, and the thickness thereof is from 1st to 3rd. The total thickness of the sheets 11, 12 and 13 is "h ₁ ".
However, as shown in FIG. 7B, when the film 4 is loaded while being displaced with respect to the holding hole 2a, the film 4 protrudes above the intermediate sheet 12 and the strip-shaped polymerized sheet 15 is formed.
Therefore, the thickness "h ₂ " of the strip-shaped polymerized sheet at this time is larger than the thickness "h ₁ " when the above-mentioned loading deviation is not present. Therefore, by detecting whether or not the thickness is in the vicinity of h ₁ by the thickness inspecting device 70, it is possible to inspect the presence or absence of misalignment.

In this way, when the inspection of the film loading deviation is made,
Next, the sheet is conveyed below the film loading inspection device 55. The film loading inspector 55 inspects whether or not light passes vertically through the through hole 1a, the holding hole 2a and the spotting hole 3a of the sheet by an optical sensor or the like, and holds the holding hole 2a.
It is to inspect whether or not the chemical analysis film 4 is loaded therein. That is, when the film 4 is not loaded in the holding hole 2a due to some trouble, the light passes through the holes 1a, 2a, 3a as it is, and therefore the film 4 is loaded by detecting the passage. It can detect the absence.

When the loading inspection of the film 4 is performed in this manner, the sheet 4 is conveyed to a position where the punching press 80 is present. The punching press 80 punches each of the bonded band-shaped polymerized sheets 15 along the chain double-dashed line in FIG. 1 for each group to punch four chemical analysis slides. When performing, the chemical analysis slide 5 that has been punched is pushed back in the direction opposite to the punching direction and pushed into the remaining portion 6 of the belt-shaped polymerized sheet 15,
A push-back system in which the chemical analysis slide 5 is held in the remaining portion 6 is adopted, and the punching press 80 will be described with reference to FIGS. 8 to 10.

As can be seen from the front view of FIG. 8 and the side view of FIG. 9, the punching press 80 includes a fixed base 81, first and second links 82 and 83, a press body 84 having a press blade, A cradle 85 fixed to a fixed base 81 facing the press body 84.
And the press body 84 is movable up and down so as to face the pedestal 85. The press body 84 is pivotally attached to the lower end of the second link 83 via a pin 83a and has a triangular second link. The first top of 82 is pivotally attached to the upper end of the first link 83 via a pin 82a, the second top is pivotally attached to a fixed base 85 via a pin 82b, and the third top is attached to a third top via a pin 82c. Through hole 81a of fixed base 81
The upper end of a connecting rod 88 extending vertically through the shaft is pivotally attached. The lower end of this connecting rod 88 has a pin on the left end.
The swing arm 87 pivotally attached to the lower fixed base 89 via 87c is pivotally attached to the right end via a pin 87a. A cam follower 87b is attached to an intermediate portion of the swing arm 87, and the cam follower 87b is fitted in a cam groove 86b of a front cam 86 that rotates around a shaft 86a. This cam groove 86b is eccentric with respect to the rotating shaft 86a, so that the front cam 86
The cam follower 87b is moved up and down by an amount corresponding to the eccentric amount of the cam groove 86b according to the rotation of the. This allows the swing arm
89 swings up and down around the pin 87c at the left end, and reciprocates up and down on the connecting rod 88 in response to this swing. By the reciprocating movement of the connecting rod, the first link 82 and the second link 83
The press body 84 is moved up and down through the press body 84 and the pedestal.
The chemical analysis slide 5 having a predetermined shape is punched out from the strip-shaped sheet 15 positioned between the chemical analysis slide 85 and the strip 85.

FIG. 10 shows the press body 84 and the pedestal 85 in a sectional view taken along the arrow P-P. As can be seen from this figure, the press body 84 includes a sheet 15 and a plurality of chemical analysis slides 5 (books). The example has a plurality of downwardly protruding press blades 84a for punching four chemical analysis slides simultaneously. The cradle 85 has a plurality of press holes 85a into which the press blades 84a are fitted according to the downward movement of the press body 84,
By fitting the press blade 84a into the press hole 85a, the chemical analysis slide 5 is punched from the belt-shaped sheet 15 arranged between the press body 84 and the receiving base 85. In the press hole 85a, a receiving plate 85b for receiving the punched chemical analysis slide 5 from the bottom is urged upward by a spring 85c. FIG. 10 shows the punched state, and the chemical analysis slide 5 punched by the press blade 84a is received by the receiving plate 85b and held in the press hole 85a. The remaining portion 6 is left between the press body 84 and the cradle 85. When the press blade 84a is fitted into the press hole 85a and punched in this way, the press blade 84a is moved upward.
At this time, since the receiving plate 85b is urged upward by the spring 85c, the chemical analysis slide 5 punched by being pushed by the receiving plate 85b is also pushed up with the upward movement of the press blade 84a, and the remaining portion 6 of the sheet is punched. The chemical analysis slide 5 that is pushed into the hole and punched by the remaining portion 6 is held. Therefore, even if the chemical analysis slide 5 is punched by the punching press 80, the chemical analysis slide 5 is strip-shaped sheet.
It is returned to the remaining portion 6 of 15 and conveyed rightward on the first conveying path 25 while being held, and is positioned below the product take-out means 90.

This product take-out means 90 is shown in detail in FIG. 11 and FIG.
FIG. 12 is a sectional view taken along arrow Q-Q in FIG. 11 and FIG. This product removing means 90 is a punching press.
It is a means for taking out the chemical analysis slide 5 punched by 80 and pushed into the remaining portion 6 and held between the remaining portions 6, and is a means for removing defective slides 5 ′ from the remaining portion 6 of the belt-shaped sheet 15 being conveyed. The non-defective product ejecting means 92 and the non-defective product pusher 98 for ejecting and ejecting the non-defective product slide 5 held in the remaining portion onto the second conveyance path 27 after the defective slide 5'is ejected. Both the defective product discharging means 92 and the good product discharging pusher 98 are attached to a ram plate 91 which is vertically movable by a ram cylinder 91a.

The defective product discharge means 92 has a sheet 15 conveyed below the means 92 as shown in the detailed structure of FIG.
4 slide loads 96 which are slidable vertically and are urged upward by springs 97, which are arranged at positions corresponding to the 4 chemical analysis slides 5 of each set, and a ram plate 92. It comprises four levers 94 rotatably supported by a support shaft 95a of a fixed support member 95, and four defective product cylinders 93 arranged corresponding to the levers 94. One end of each lever 94 contacts the upper end 96a of the sliding rod 96 moved upward by the spring 97, and the other end contacts the cylinder rod 93a of the defective product cylinder 93. When the cylinder rod 93a is moved upward by the cylinder 93, the lever 94
The sliding rod 96 is moved downwards via the so that the defective product discharge pusher 96b fixed to the lower end of the sliding rod 96 is moved downward. Further, the non-defective product pushers 98 are four pushers for taking out the non-defective product slides 5 from the sheet 15 after the defective slides 5 ′ are ejected by the defective product ejecting means 92, and are provided below the ram plate 91. It is mounted so as to project.

The operation of the product take-out means 90 having the above structure will be described.
First, when the strip-shaped sheet 15 is conveyed below the defective product discharging means 92, at this position, the conveyance of the sheet 15 is stopped, the positioning pin is inserted into the positioning hole, and the positioning is performed. 91 is moved downward by driving the ram cylinder 91a. The defective product discharge pusher 96b of the defective product discharge means 92 has a small amount of downward projection when the defective product cylinder 93 is not operated, and the defective product discharge pusher 96b remains even if the ram plate 91 is moved downward. The chemical analysis slide 5 held in 6 does not come into contact with the chemical analysis slide 5, and the chemical analysis slide 5 is left held in the remaining portion 5. Conversely, when the defective product cylinder 93 is operated and the defective product discharge pusher 96b is moved downward, when the ram plate 91 is moved downward, the defective product discharge pusher 96b is retained in the remaining portion 6. The analytical slide 5 is abutted and removed from the remaining portion 6 of the chemical analytical slide 5. Therefore, when a defective slide 5'is detected by the film height inspecting device 70 and the film loading inspecting device 55, the defective product cylinder 93 is moved so that the defective product discharge pusher 96b corresponding to the defective slide 5'is moved downward. When the ram plate 91 moves downward, the defective slide 5'is pushed downward to be discarded in the waste box 29a. After removing defective products in this way,
The sheet 15 is conveyed below the non-defective product pusher 98. As can be seen from FIG. 12, the non-defective product pusher 98 projects downward from the defective product pusher 96b, and when the ram plate 91 is moved down, the non-defective product pusher 98 is always brought into contact with the chemical analysis slide 5 held in the remaining portion 6. The chemical analysis slides 5 held in the remaining portion 6 are discharged onto the second transport path 27 located therebelow, and the non-defective slides 5 are transported backward on the second transport path 27. The remaining portion 6 left after the chemical analysis slide 5 is taken out is cut into an appropriate length by the cutter 57 driven by the cutter cylinder 57a and is disposed in the disposal box 29b.

Here, a method of transporting the strip-shaped sheet 15 on the first transport path 25 with a feed pin and a method of positioning with a positioning pin at a predetermined position will be described with reference to FIGS. 14 and 15. FIG. 14 is a cross-sectional view of the strip-shaped sheet 15 placed on the first conveying path 25 along a vertical plane extending in the feeding direction. FIG. 15 shows a vertical plane perpendicular to the vertical plane. FIG. A feed pin support 66a that is movable back and forth is arranged in the center of the transport path, and the feed pins 66 are fixedly mounted on the support at predetermined intervals. Therefore, each feed hole 15c of the sheet 15 placed on the first transport path 25
The feed pin 66 is inserted into (the hole formed by the feed holes 11c, 12c, and 13c overlapping), and the feed pin 6 is inserted together with the support 66a.
When 6 is moved in the feeding direction, the sheet 15 is conveyed along the conveying path 25. A pair of locator pins 67 supported by a vertically movable locator pin support 67a is arranged at a position where a predetermined work is performed by a device such as the ultrasonic welders 51, 53. 66a is moved downward so that the feed pin 66 is removed from the feed hole 15c, and the locator pin support 67a is moved downward so that the locator pin 67 is positioned in the positioning hole 1
Each work is performed after the sheet 15 is positioned by being inserted into the 5b (holes formed by overlapping the positioning holes 11b, 12b, 13b).

On the other hand, the non-defective slide 5 transported on the second transport path 27 is
After being transported from the second transport path 27 onto the third transport path 28, predetermined data such as a lot number and a date are printed on the surface of the inkjet printer 59 provided in the third transport path 28, and then the dryer 61. This print is dried by
The chemical analysis slides 5 are transferred one by one onto the transfer Nos. 65 and 65 by the transfer arm 65, and are stacked and accumulated on the accumulating pallet 100 from the transfer Nos. 65 and 65 by the arm 68 of the accumulating robot 67.

The above-mentioned device is operated by operating the operation switch 26 provided at the front of the device.

(Effects of the Invention) As described above, according to the present invention, a plurality of strip-shaped plastic sheets having slits extending in the axial direction and having a constant interval in the longitudinal direction are vertically stacked and conveyed in the longitudinal direction. Sheet conveying means, a film arranging means for sequentially holding the chemical analysis film between the strip-shaped plastic sheets conveyed by the sheet conveying means at a predetermined interval, and a strip-shaped plastic which holds the chemical analysis film and is vertically stacked. In the portion surrounding each of the chemical analysis films, the sheet-making sheet is joined to the sheet-conveying means to form a belt-shaped polymerized sheet by sequentially adhering to each other in accordance with the conveyance by the sheet-conveying means, and the belt-shaped polymerized sheet is conveyed by the sheet-conveying means. Correspondingly, punching means for punching in each peripheral portion of the chemical analysis film and the above-mentioned strip-shaped plastic The manufacturing apparatus of the present invention is composed of positioning pins inserted into each of the positioning holes so as to position each part of the strip-shaped plastic sheet before the operation of laminating the sheet made of the metal or the punching operation of the chemical analysis film is performed. As a result, the chemical analysis slide can be continuously manufactured by a device having a relatively simple structure.

In addition, slits extending in the width direction are provided in advance at regular intervals in the longitudinal direction, and at least one positioning hole is provided in advance in each of the remaining portions between the slits for bonding or punching. Before the above work is performed, the positioning pin can be inserted into the positioning hole to position each part of the sheet, and the strain generated in the sheet due to this positioning operation can be absorbed by the slit. Therefore, it is possible to ensure the positioning operation of the material sheet when manufacturing the chemical analysis slide, and it is possible to make the dimensional error of the chemical analysis slide extremely small.

[Brief description of drawings]

FIG. 1 is a perspective view schematically showing a manufacturing process of a scientific analysis slide performed by using the manufacturing apparatus of the present invention, FIGS. 2 and 3 are front views and plan views showing the manufacturing apparatus, and FIG. 4A. And FIG. 4B is a plan view and a sectional view showing in detail the high-speed transfer means in the above manufacturing apparatus, FIG. 4C is a plan view showing a different example of the high-speed transfer means, and FIG. A plan view, FIG. 6 is a front view showing a thickness inspector in the above manufacturing apparatus, FIGS. 7A and 7B are cross-sectional views showing a belt-shaped polymerized sheet, and FIGS. 8 and 9 are punching presses in the above manufacturing apparatus. 10 is a front view and a side view showing the structure of FIG. 10, FIG. 10 is a cross-sectional view taken along the arrow P-P in FIG. 9, and FIGS. 11 and 12 are front views and plan views showing the product take-out means in the manufacturing apparatus. , Fig. 13 11 is a cross-sectional view showing the product take-out means of FIG. 11 along the arrow Q-Q, and FIGS. 14 and 15 are cross-sectional views showing the strip-shaped sheet placed on the first transport path together with the first transport path. FIG. 16 is a perspective view showing a chemical analysis slide made by the above manufacturing apparatus. 1 …… Mount base 2 …… Mount frame 3 …… Mount cover 4 …… Chemical analysis film 11,12,13 …… Plastic sheet 15 …… Band-shaped sheet, 21,22,23,31 …… Reel 40 ...... Pallet transport unit, 51,53 ・ ・ ・ Ultrasonic welding device 55 …… Film filling inspection device, 57 …… Cutter 59 …… Inkjet printer 70 …… Film thickness inspection device, 80 …… Punching press 90 …… Products Ejection means, 92 …… Defective product ejection means 98 …… Good product ejection pusher 100 …… High-speed transfer means

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location G01N 33/52 B

Claims (2)

[Claims] 1. A plurality of strip-shaped plastic sheets, each having a certain interval in the longitudinal direction and having slits extending in the width direction and positioning holes respectively located between these slits, are vertically stacked and conveyed in the longitudinal direction. A sheet conveying means, a film arranging means for sequentially sandwiching a plurality of chemical analysis films at a predetermined interval between the strip-shaped plastic sheets conveyed by the sheet conveying means, and a chemical analysis film sandwiched above and below. Sheet bonding means for forming the belt-shaped polymer sheet by sequentially stacking the overlapped belt-shaped plastic sheets on top of each other in the area surrounding each of the chemical analysis films in accordance with the conveyance by the sheet conveying means, and the belt-shaped polymer sheet. According to the conveyance by the above-mentioned sheet conveying means, sequentially around each of the chemical analysis films. The punching means for punching and the punching operation of the strip-shaped plastic sheet or the punching operation of the chemical analysis film before the punching operation of the strip-shaped plastic sheet are performed by the positioning holes inserted in the respective positioning holes. A continuous manufacturing apparatus for chemical analysis slides, which comprises a pin. 2. A belt-shaped plastic sheet, comprising: a first sheet having a plurality of concentration measuring through holes formed at predetermined intervals;
The second sheet has holding holes for holding the chemical analysis film at predetermined intervals, and the third sheet has a plurality of spotting holes formed at predetermined intervals. Holding the chemical analysis film, and holding the second sheet from above and below by the first and third sheets such that the through hole, the holding hole and the spotting hole face each other in the vertical direction, and the sheet joining means. The continuous manufacturing apparatus for chemical analysis slides according to claim 1, characterized in that the first to third sheets are adhered to each other.