NZ775331B2 - Aerosolisable formulation - Google Patents
Aerosolisable formulation Download PDFInfo
- Publication number
- NZ775331B2 NZ775331B2 NZ775331A NZ77533119A NZ775331B2 NZ 775331 B2 NZ775331 B2 NZ 775331B2 NZ 775331 A NZ775331 A NZ 775331A NZ 77533119 A NZ77533119 A NZ 77533119A NZ 775331 B2 NZ775331 B2 NZ 775331B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- aerosolisable formulation
- acid
- aerosolisable
- nicotine
- flavours
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/05—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Abstract
There is provided an aerosolisable formulation comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; (ii) nicotine; (iii) an acid; and (iv) one or more cyclodextrins. There is also provided a process for forming an aerosol, the process comprising aerosolising an aerosolisable formulation comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; (ii) nicotine or one or more flavours; (iii) an acid; and (iv) one or more cyclodextrins.
Claims (29)
1. An aerosolisable formulation comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; 5 (ii) nicotine; (iii) an acid; and (iv) one or more cyclodextrins.
2. An aerosolisable formulation according to claim 1 wherein water is present in an 10 amount of at least 90 wt.% based on the aerosolisable formulation.
3. An aerosolisable formulation according to claim 1 or 2 wherein water is present in an amount of at least 95 wt.% based on the aerosolisable formulation. 15
4. An aerosolisable formulation according to any one of claims 1 to 3 wherein water is present in an amount of at least 99 wt.% based on the aerosolisable formulation.
5. An aerosolisable formulation according to any one of claims 1 to 4 wherein the nicotine is present in an amount of no greater than 1 wt.% based on the aerosolisable 20 formulation.
6. An aerosolisable formulation according to claim 5 wherein nicotine is present in an amount of from 0.01 to 0.6wt.% based on the aerosolisable formulation. 25
7. An aerosolisable formulation according to claim 1 wherein the acid is selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof. 30
8. An aerosolisable formulation according to claim 7 wherein the acid is selected from the group consisting of citric acid, benzoic acid, levulinic acid, sorbic acid, lactic acid, and mixtures thereof.
9. An aerosolisable formulation according to claim 7 or claim 8 wherein the acid is at 35 least citric acid.
10. An aerosolisable formulation according to any one of claims 7 to 9 wherein the total content of acid present in the formulation is no greater than 1 mole equivalents based on the nicotine.
11. An aerosolisable formulation according to any one of claims 7 to 10 wherein the total 5 content of acid present in the solution is no less than 0.1 mole equivalents based on the nicotine.
12. An aerosolisable formulation according to any one of claims 1 to 11 further comprising one or more flavours.
13. An aerosolisable formulation according to claim 12 wherein the one or more flavours are selected from the group consisting of (4-(para-)methoxyphenyl)butanone, vanillin, ?- undecalactone, menthone, 5-propenyl guaethol, menthol, para-menthathiolone and mixtures thereof.
14. An aerosolisable formulation according to claim 13 wherein the flavour is at least menthol.
15. An aerosolisable formulation according to any one of claims 12 to 14 wherein the one 20 or more flavours are present in a total amount of no greater than 2wt.% based on the aerosolisable formulation.
16. An aerosolisable formulation according to any one of claims 12 to 15 wherein the one or more flavours are present in a total amount of from 0.01 to 1wt.% based on the 25 aerosolisable formulation.
17. An aerosolisable formulation according to any one of claims 1 to 16 wherein the aerosolisable formulation contains no flavours that can be encapsulated by the one or more cyclodextrins.
18. An aerosolisable formulation according to any one of claims 1 to 11 wherein the aerosolisable formulation contains no flavours.
19. A process for forming an aerosol, the process comprising aerosolising an 35 aerosolisable formulation comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; (ii) nicotine or one or more flavours; (iii) an acid; and (iv) one or more cyclodextrins.
20. A process according to claim 19 wherein the aerosolisable formulation comprises 5 nicotine and, optionally, one or more flavours.
21. A process according to claim 20 wherein the aerosolisable formulation is an aerosolisable formulation as defined in any one of claims 2 to 18. 10
22. A process according to claim 19, 20 or 21 wherein the aerosol is formed by a process performed at a temperature below 50°C.
23. A process according to any one of claims 19 to 22 wherein the aerosol is formed by applying ultrasonic energy to the aerosolisable formulation.
24. A contained aerosolisable formulation comprising (a) a container; and (b) an aerosolisable formulation , comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; 20 (ii) nicotine; (iii) an acid; and (iv) one or more cyclodextrins.
25. A contained aerosolisable formulation according to claim 24 wherein the 25 aerosolisable formulation is an aerosolisable formulation as defined in any one of claims 2 to
26. A contained aerosolisable formulation according to claim 24 or 25 wherein the container is configured for engagement with an electronic aerosol provision system.
27. An electronic aerosol provision system comprising: (a) an aerosoliser for aerosolising formulation for inhalation by a user of the electronic aerosol provision system; (b) a power supply comprising a cell or battery for supplying power to the aerosoliser 35 (c) an aerosolisable formulation , comprising (i) water in an amount of at least 85 wt.% based on the aerosolisable formulation; (ii) nicotine or one or more flavours (iii) an acid; and (iv) one or more cyclodextrins.
28. An electronic aerosol provision system according to claim 27 wherein the 5 aerosolisable formulation comprises nicotine and, optionally, one or more flavours.
29. An electronic aerosol provision system according to claim 27 or 28 wherein the aerosolisable formulation is an aerosolisable formulation as defined in any one of claims 2 to -1 -0.5 0 0.5 1.0 1.5 log [conc]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1817865.7A GB201817865D0 (en) | 2018-11-01 | 2018-11-01 | Aerosolisable formulation |
| PCT/GB2019/053092 WO2020089637A1 (en) | 2018-11-01 | 2019-10-31 | Aerosolisable formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ775331A NZ775331A (en) | 2024-09-27 |
| NZ775331B2 true NZ775331B2 (en) | 2025-01-07 |
Family
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