JP2970769B2 - Whitening cosmetics - Google Patents

Description

The present invention relates to a whitening cosmetic.

More specifically, the present invention relates to a whitening cosmetic containing an extract of a specific seaweed as an active ingredient.

[Conventional technology]

Conventionally, those having a tyrosinase activity inhibitory effect can be expected to have an effect of whitening the skin, and cosmetics containing various substances having a whitening effect having this effect have been used.

Representative examples thereof include L-ascorbic acid or a fatty acid derivative thereof, and phosphorylated ascorbic acid or a salt thereof.

However, L-ascorbic acid or its fatty acid derivative as a whitening agent substance has drawbacks such as being weak to heat and light, having poor stability in an aqueous solution, and causing decomposition and coloring.

Phosphorylated ascorbic acid or a salt thereof is excellent in stability, but has a problem that, for example, precipitation occurs over time when it is added to a lotion or the like.

Others are known as whitening agents such as kojic acid and arbutin. However, conventional whitening agents have problems in stability and safety, such as kojic acid causing coloring depending on the formulation.

Examples of whitening cosmetics or melanin formation inhibitors containing a seaweed extract include JP-A-1-224308 and JP-A-2-224308.
-88592 and JP-A-2-124810.

JP-A 1-2224308 discloses brown alga hiba, konbu,
It is a cosmetic formulation containing a water-soluble extract containing no phenolic compound extracted from Kurome, Arana, Homura, etc. and having no gel-forming ability.

JP-A-2-88592 discloses a melanogenesis inhibitor extracted from brown algae, green algae and red algae, and mainly focuses on the activity of brown algae. That is, it is an extract from seaweed, mainly wakame, konbu, kajime, and obamoku.

Examples of red algae include rice paste, openness, and swelling paste.

JP-A-2-124810 is a cosmetic composition containing a hydrophilic solvent extract of a seaweed belonging to the order Brown algae, in particular, the order Himata or Laminaria. Extracts of hijiki, wakame and arame are illustrated.

[Problems to be solved by the invention]

The present inventors have conducted an experiment and found that the tyrosinase activity inhibitory effect of the seaweed extract described in the above publication is not so strong, and that the effect differs greatly depending on the species of seaweed.

An object of the present invention is to strongly inhibit tyrosinase activity,
Another object of the present invention is to provide a whitening agent which is safe in the long term and which is easy to use, and which is safe and has a strong whitening effect.

[Means for solving the problem]

The present invention is a whitening cosmetic containing an extract of at least one water or a hydrophilic organic solvent selected from the group consisting of the seaweeds belonging to the genus Rinaceae and the genus Rinaceae.

The present inventors have paid attention to the fact that the tyrosinase activity inhibitory effect varies greatly depending on the type of seaweed, and measured the tyrosinase activity inhibitory effect of various red algae.

9 times the volume of sodium phosphate buffer (10 mM, pH 6.
8) was added and homogenized sufficiently. This was centrifuged to remove insolubles and passed through a 0.45μ filter. The following experiment was performed using this as a sample.

0.9ml of sodium phosphate buffer (30mM, pH6.8), 1.66
1.0 ml of the mM tyrosine solution and 1.0 ml of the sample solution were placed in a screw vial, and heated in a constant temperature water bath at 37 ° C. for 5 minutes or more.

0.1 ml of a tyrosinase solution (manufactured by Sigma, from mushrooms, 914 Units / ml) was added, the mixture was kept warm in a water bath at 37 ° C, and the absorbance was measured at 475 nm after 10 minutes.

As a control, pure water was added instead of the sample solution, and the measurement was performed in the same manner.

 The tyrosinase activity inhibition rate (%) was calculated by the following equation.

 Tyrosinase activity inhibition rate (%) = [{B- (AP)} / B] x 100 where A: absorbance of test sample B: absorbance of control P: absorbance by coloring test sample (3 times dilution) The result is as shown in Table 1.

(Melanin production inhibition test) (Judgment criteria) Judgment by whiteness Score-: No whitening +: Slight whitening ++: Clear whitening +++: Strong whitening ++ indicates melanin production inhibitory ability, +
The higher the value, the stronger the ability to suppress melanin production.

Table 2 shows the results of the melanin production suppression test performed on the seaweed extract (Hatsumatsu, Obankintoki) of the present invention.

In the above-mentioned JP-A-2-88592, red algae, which are already known as red algae having a tyrosinase activity inhibitory action, such as swelling paste, swelling paste,
The names "Onogori" and "Fukunori" do not exist as general names. If the weight is incorrect, the tyrosinase activity inhibition is very low compared to the present invention.
In addition, if the laver is a common name for the laver, it can be said that the effect is also very low as compared with the present invention. However, as a red algae, there is indeed openness, but this is almost so much as tyrosinase activity inhibition,
The absence of inhibition is also evident from the above test results.

On the other hand, it was revealed that the red algae of the present invention, which is a member of the genus Kinto, of the genus Oribataceae, has a very strong tyrosinase activity inhibitory effect.

As the hydrophilic organic solvent as the extractant, methanol,
Lower alcohols such as ethanol and isopropanol,
Examples thereof include ketones such as polyoxyethylene ethers and acetone.

〔Example〕

Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.

(Example 1) Formulation of lotion% by weight Ethanol 10 1.3 Butylene glycol 10 Single extract (solids) 1 Water 79 (Example 2) In Example 1, single extract (solids) was extracted at a time (Solid)

(Comparative Example 1) In Example 1, the extract (solid) was replaced with water.

Sensory evaluation A questionnaire was taken for 15 women and 8 men for 2 months.

The evaluation was performed on a five-point scale and described as follows.

 +5 Example is much better.

 +4 Example is much better.

 +3 Example is better.

 +2 Example is slightly better.

 The +1 embodiment is slightly better.

 0 No difference.

 -1 The comparative example is slightly better.

 -2 The comparative example is slightly better.

 -3 The comparative example is better.

 -4 Comparative example is considerably better.

 -5 The comparative example is much better.

 All Comparative Examples were performed as Comparative Example 1.

 Table 3 shows the total value.

As described above, seaweed belonging to the genus Rinaceae in the red algae family has a strong inhibitory effect on tyronase activity and is therefore excellent in whitening effect. .

〔The invention's effect〕

According to the present invention, red algae, a seaweed belonging to the genus Kinoshita, belonging to the genus Kinto, a cosmetic containing an extract with at least one water or a hydrophilic organic solvent selected from Obakin have a strong tyrosinase activity inhibitory action. In tyrosinase activity inhibition and panel tests, it was clear that the action was stronger than that of other seaweeds.

Since this seaweed is partially used for food, it is safe for the skin in the long term.

Therefore, it is very useful as a raw material for cosmetics, both in terms of safety and its effects.

Claims (1)

(57) [Claims] 1. A whitening cosmetic comprising an extract of at least one water or a hydrophilic organic solvent selected from the group consisting of the seaweed belonging to the genus Red seaweed Muscarinae and the genus Kinto.