JP3175607B2 - Aqueous adhesive composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aqueous pressure-sensitive adhesive composition having not only an enhanced edema inhibitory effect but also excellent skin safety.

[0002]

2. Description of the Related Art Conventionally, an aqueous pressure-sensitive adhesive composition has been used to relieve and remove swelling and heat of an affected part by cooling, as well as relieve muscle inflammation and pain due to bruising, spraining and the like. It is used as an external preparation.
The swelling and pain (edema) of the affected area due to such inflammation are caused by the retention of water in the affected area, and an essential oil component (essential oils) having a diuretic effect and / or Or extracts are known to be effective (Wanda Cellar, "84 Essential Oil Components for Aromatherapy", Fragrance Journal). However, if only a small amount (5% by weight or less) of an essential oil component and / or an extract having a diuretic effect is added to the aqueous adhesive base, a sufficient diuretic effect cannot be obtained, and no edema-improving effect is observed. On the other hand, in order to obtain a sufficient edema-improving action, essential oil components and / or extracts are used in large amounts (10% by weight or more).
When mixed, an edema-improving effect can be obtained, but the physical properties of the aqueous pressure-sensitive adhesive composition change, causing “liquid dripping” and “stickiness”, which is problematic in terms of usability when used as an external preparation. In addition, redness and itching occur in terms of skin irritation, which is not preferable in terms of safety.

[0003] The present invention has been made in view of the above circumstances, and is excellent even if the blending amount of essential oils and / or extracts having a diuretic effect extracted from a specific plant is small, for example, 5% by weight or less. The present invention has an object to provide an aqueous pressure-sensitive adhesive composition that has excellent edema-improving effect, has excellent usability as an external preparation, does not cause redness or rash when applied to the skin, and has excellent safety. Is what you do.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, a substance (cooling agent) that gives a refreshing feeling such as menthol.
And an essential oil and / or extract having a diuretic effect extracted from a specific plant in an aqueous adhesive base, so as not to cause skin irritation such as pain or redness at the time of application to the skin. Alternatively, it has been found that even if the amount of the extract is small, for example, 5% by weight or less, the edema improving effect is significantly enhanced, and the present invention has been accomplished.

That is, the present invention relates to (A) a substance imparting a refreshing sensation, and (B) extraction from chamomile, sage, parsley, rosemary, sycamore, sycamore, cornflower, anise, laurel, angelica, fennel and thyme. The present invention provides an aqueous pressure-sensitive adhesive composition characterized by comprising one or more essential oils and / or extracts having a diuretic action selected from the group consisting of a substance and an aqueous pressure-sensitive adhesive base. Here, the substance (A) for imparting a refreshing feeling is l
Essential oils containing menthol and / or 1-menthol, N-substituted-p-menthan-3-carboxamide, 3
More preferably, it is one or more selected from the group consisting of -substituted-p-menthane, 2- or 3-substituted-p-menthanediol, trialkyl-substituted cyclohexanecarboxyamide and isopulegol, and the above (A) )
When the compounding ratio (weight ratio) of the substance imparting a refreshing sensation and the essential oils and / or extracts (B) having a diuretic action is (A) :( B) = 1: 0.001-2. Is more preferable. And it is more preferable that the aqueous adhesive base contains a crosslinked product of polyacrylic acid and polyacrylate. Further, the present invention is selected from the group consisting of a substance that imparts a refreshing sensation and extracts from chamomile, sage, parsley, rosemary, sycamore, sycamore, cornflower, anise, laurel, angelica, fennel, lavender, and thyme. Provided is an aqueous pressure-sensitive adhesive composition, characterized in that one or more essential oils and / or extracts having a diuretic action are blended in an aqueous pressure-sensitive adhesive base as an edema improving agent.

Hereinafter, the present invention will be described in more detail. The aqueous pressure-sensitive adhesive composition of the present invention comprises (A) a substance imparting a refreshing sensation, and (B) essential oils having a diuretic action extracted from a specific plant. And / or an extract as an essential component. Here, as the substance imparting a refreshing sensation, which is the component A of the present invention, for example, 1-menthol, N-substituted-p-menthan-3-carboxamide, 3-substituted-p-
Menthane, 2- or 3-substituted-p-menthanediol,
Trialkyl-substituted cyclohexanecarboxyamide,
Isopulegol and the like can be mentioned, and these can be used alone or in combination of two or more. Among them, l-menthol is particularly preferred because it strongly exerts an analgesic and anti-inflammatory action. It is desirable to use menthol alone or in combination with other cooling agents. When l-menthol is used, l-menthol itself may be blended, or it may be blended as it is contained in essential oils as a fragrance component, for example, as peppermint oil. You may.

[0007] The compounding amount of the substance for imparting a refreshing sensation is preferably 0.001 to 5% (% by weight, hereinafter the same), particularly preferably 0.01 to 2% of the whole composition. 0.001%
If it is less than 5%, the effect of the substance may not be sufficiently obtained, and if it exceeds 5%, the skin may have a strong irritating feeling.

[0008] The aqueous pressure-sensitive adhesive composition of the present invention further comprises, as a B component, essential oils and / or extracts having a diuretic action extracted from a specific plant. In this case, essential oils are volatile oils that have a peculiar fragrance of plants, which are raw materials, and are insoluble in water, alcohol,
It is an oil having the property of being soluble in carbon disulfide, petroleum ether, fatty oil and the like, and these essential oils are generally obtained by steam distillation. On the other hand, extracts are prepared, for example, by adding an appropriate leachate to crude crude drug, leaching by cold immersion, hot immersion or percolation method of tincture, and filtering, concentrating and drying the obtained leachate. It was done. The leaching solution is selected in consideration of the properties of the crude drug, especially its chemical components, but generally a mixture of ethanol and water is often used, and water and polyols are also used. In some cases, an acid or an alkali may be added. Therefore, extracts have many hydrophilic components.

The essential oils and extracts having a diuretic effect of the component (B) of the present invention are obtained by extraction from specific plants, and include chamomile, sage, parsley, rosemary, sycamore, sycamore, cornflower and anise. , Laurel, angelica, fennel, lavender, thyme and the like. Specific components of such extracts include, for example, monoterpene hydrocarbons,
Cineole, borneol, camphor, camphor,
Linalool, berbenol, flavonoids, choline,
Amino acids, tannins, vegetable acids, fatty acids, hydrocyanic acid glycosides, salicylic acid derivatives, salvin, condensed tannins, phenolic acids, carnosic acid, triterpenic acid, thuyon, salben, pinene, apiol, apiolin, myristine,
Coumarin, kama azulene, farnesene, bisabolol, geraniol, eugenol, terpene, ferrandrin, anethole, menthol, menthone, limonene, citral, citronellal, eugenol acetate and the like can be mentioned. The above-mentioned essential oils and extracts can be used alone or in combination of two or more.

[0010] The amount of the essential oils and / or extracts varies depending on the type of the substance that imparts a refreshing sensation, but the compounding ratio (weight ratio) to the substance that imparts a refreshing sensation is usually reduced. Substance to be applied: Essential oils and / or extracts = 1: 0.001-2, preferably 1: 0.003-1. If the ratio of essential oils and / or extracts is less than 0.001, it may be difficult to obtain the effect of adding essential oils and extracts, and if it exceeds 2, skin irritation may occur due to the addition of essential oils and extracts. is there.
Further, the total blending amount of the substance imparting a refreshing sensation and the essential oils and / or extracts is 0.01 to 8%, preferably 0.01 to 5%, more preferably 0.02 to 8% of the whole composition. 3
%. If it is less than 0.01%, it may be difficult to obtain the effect of adding essential oils and extracts, and if it exceeds 8%, problems such as a change in physical properties of the aqueous pressure-sensitive adhesive composition may occur.

Here, the aqueous pressure-sensitive adhesive composition of the present invention more preferably uses an aqueous pressure-sensitive adhesive base containing a crosslinked product of polyacrylic acid and polyacrylate as the aqueous pressure-sensitive adhesive base. This aqueous pressure-sensitive adhesive base has a high water content and, moreover, has excellent adhesion to the skin.
By combining the substance imparting a refreshing feeling of the present invention with essential oils and / or extracts extracted from specific plants, the effect of the aqueous pressure-sensitive adhesive composition of the present invention on edema suppression becomes more remarkable. Can be.

The crosslinked product of polyacrylic acid and polyacrylic acid salt is not particularly limited, and known ones can be used. For example, JP-A-59-110614 and JP-A-59-110614 can be used.
No. 110616, No. 59-110617, No. 60-
99180, 60-260512, 60-26
An aqueous pressure-sensitive adhesive base containing a metal crosslinked product of polyacrylic acid and a polyacrylate described in JP-A-0513 or the like is preferable.

Specifically, any polyacrylic acid can be used as the aqueous pressure-sensitive adhesive base of the present invention. The molecular weight and the shape such as linear or branched chain are not particularly limited. It is preferable to use those having a molecular weight of 10,000 to 10,000,000, and in particular, to combine two or more kinds of polyacrylic acids having an average molecular weight of 10,000 to less than 500,000, 500,000 to less than 2,000,000, and 2,000,000 to 4,000,000. This is preferable because the feeling of use is improved. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as Carbopol (trade name: manufactured by Goodrich Corporation, USA) can be suitably used.

Examples of polyacrylates include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, triethanolamine polyacrylate and the like. One or two of amine salt of polyacrylic acid, ammonium salt of polyacrylic acid, etc.
More than one species may be suitably used.

The mixing ratio (weight ratio) of polyacrylic acid and polyacrylate is preferably 1: 0.1 to 1:10, particularly preferably 1: 1 to 1: 9. An acid or salt partially neutralized so that the polyacrylate has the above ratio may be used. Further, the total blending amount of polyacrylic acid and polyacrylate is preferably 0.5 to 20%, particularly 1 to 15% of the whole composition, and if it is less than 0.5%, the adhesive strength may be insufficient. Yes, if it exceeds 20%, the viscosity becomes high, which may cause a problem in workability during production.

Here, the aqueous adhesive base of the present invention is preferably one obtained by crosslinking polyacrylic acid and polyacrylate by adding an appropriate crosslinking agent. The type of is not particularly limited as long as the polyacrylic acid and the polyacrylate can be cross-linked, but a polyvalent metal compound is particularly preferably used. In this case, as the polyvalent metal compound, a magnesium compound, a calcium compound, a zinc compound, a cadmium compound, an aluminum compound, a titanium compound, a tin compound, an iron compound,
Although a chromium compound, a manganese compound, a cobalt compound, a nickel compound and the like can be used, the aqueous pressure-sensitive adhesive composition of the present invention is applied to the skin, and if safety to the skin is taken into consideration, an aluminum compound, a magnesium compound It is preferable to use a calcium compound or the like.

In this case, any of the aluminum compound, magnesium compound and calcium compound can be suitably used. For example, alums such as potassium alum, ammonium alum, iron alum, aluminum hydroxide, aluminum sulfate, aluminum ammonium sulfate, Aluminum potassium sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, aluminum oxide, synthetic aluminum silicate, aluminum metasilicate, calcium hydroxide, calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate, Magnesium hydroxide, magnesium carbonate, magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, Mina magnesium, magnesium aluminometasilicate, magnesium aluminosilicate, synthetic hydrotalcite, water-soluble compounds such as double salts containing these metals, may be used one or more poorly water-soluble compounds.

The preferred amount of the crosslinking agent varies depending on the type thereof. For example, when the polyvalent metal compound is used, the amount is preferably 0.001% of the total composition.
-10%, particularly preferably 0.01-5%. If it is less than 0.001%, the cohesive strength of the composition may decrease, and if it exceeds 10%, the adhesive strength may decrease.

The water content of the aqueous pressure-sensitive adhesive base is preferably 30% or more, particularly preferably 35 to 75%. If it is less than 30%, the viscosity of the aqueous pressure-sensitive adhesive base becomes high, which may cause a problem in productivity.

The aqueous pressure-sensitive adhesive composition of the present invention may optionally contain, in addition to the above-mentioned essential components, other components added to a compress sheet or the like, if necessary, as long as the effects of the present invention are not impaired. Can also. However, the aqueous pressure-sensitive adhesive composition of the present invention is used for the purpose of imparting an edema-suppressing effect by being applied to the skin, and does not require the incorporation of a medicinal component.

Further, a cellulose derivative and a polyhydric alcohol can be added to the aqueous pressure-sensitive adhesive base of the present invention as long as the effects of the present invention are not impaired. In this case, any of the cellulose derivatives may be used. For example, one or more of alkali metal salts of carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose and the like may be used. Alkali metal salts of carboxymethylcellulose such as sodium methylcellulose and potassium carboxymethylcellulose can be suitably used. In addition, when adding a cellulose derivative, it is preferable that the compounding quantity is 15% or less of the whole composition. If it exceeds 15%, the viscosity will be high, which may cause a problem in workability during production. As the polyhydric alcohol, any of the commonly used alcohols can be used. For example, glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-propanediol, One or more of 4-butanediol, maltitol, xylitol and the like can be used. In addition, when adding a polyhydric alcohol, it is preferable that the compounding quantity is 50% or less of the whole composition. If it exceeds 50%, the cohesive force of the aqueous pressure-sensitive adhesive base is reduced, and the aqueous pressure-sensitive adhesive base may remain on the adherend during peeling.

Examples of water-soluble high molecular substances of polyacrylic acid, polyacrylate, and cellulose derivative include polyvinyl alcohol, polyvinylpyrrolidone, gelatin, pectin, vinylpyrrolidone / vinyl acetate copolymer, hydroxypropylcellulose, and sodium alginate. , Xanthan gum, tragacanth, and the like. When these water-soluble polymers are blended, the blending amount is preferably 10% or less of the whole composition.

As base components other than these water-soluble polymer substances and crosslinking agents, conventionally used components, for example,
Inorganic powders, surfactants, preservatives, emulsifiers and the like can be added.

As the inorganic powder, kaolin, titanium oxide,
Talc, bentonite, zinc oxide, montmorillonite,
Silicic anhydride and the like can be mentioned. As surfactants, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene Ethylene phytosterols, sorbitan fatty acid esters, glycerin fatty acid esters and the like may be added.

As preservatives, aminoethylsulfonic acid, benzoic acid, sodium benzoate, benzyl benzoate, anthracite, liquid phenol, ethanol, sodium edetate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dried sodium sulfate , Agar, dl-camphor, strong sunpreza-N,
Citric acid, sodium citrate, chlorocresol, chlorobutanol, gentisic acid ethanolamide, salicylic acid, sodium salicylate, dibutylhydroxytoluene 2,6-di-t-butyl-4-methylphenol, seycept, sorbic acid, potassium sorbate, Nitrogen, thymol, dehydroacetic acid, sodium dehydroacetate, 2-naphthol, concentrated benzalkonium chloride solution 50,
Sucrose, honey, isobutyl parahydroxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, paraformaldehyde, phenylethyl alcohol, phenol, proxel GXL, benzyl alcohol, borax Acid, borax, d
-Borneol, l-menthol, eucalyptus oil, oxyquinoline sulfate, isopropylmethylphenol, undecylenic acid monoethanolamide, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride,
Alkyl diaminoethyl glycine hydrochloride solution, chlorhexidine hydrochloride (gluconic acid), orthophenylphenol,
Cresol, chloramine T, chlorxylenol, chlorphenesin, alkylisoquinolinium bromide solution, domiphen bromide, thianthol, trichlorocarbanilide,
Parachlorophenol, halocarban, 2- (2-hydroxy-5-methylphenyl) benzotriazole, hexachlorophen, resorcin, phenoxyethanol and the like can be added.

Examples of the emulsifier include methyl acrylate / -2-ethylhexyl acrylate copolymer resin emulsion,
Sodium N-acyl-L-glutamate, Atmos 3
00, Amacol CAB, allyl glycidyl ether,
Ethanol, ethylene glycol monomethyl ether,
Emamin D500B, Emarex AC-10, Cetylpyridinium chloride, Benzalkonium chloride, Alkyldiaminoethylglycine hydrochloride solution, Eimulgin C100
0, Eimulgin C700, octyldodecanol, oleyl alcohol, carrageenan, potash ken, carboxyvinyl polymer, carmellose sodium, reduced lanolin, guar gum, claude base 25, glycerin, highly purified egg yolk lecithin, sanimal 234NS, sanimal 235, sanimal 250-C, Sanimaru 250C
(75), Sanimaru 258B2, Sanimaru 258BA,
Sanimaru 258BA2, Sanimaru 258N, Sanimaru 2
65, Sanimaru 451-KT, Sanimaru 55-HX, Sanimaru 55-LX, Sanimaru DVP, Sanimaru K-5
1. Sanimal K-51 (75), Sanimal PCS, Sanimal SN-155, Sanimal ST-451, Salami beeswax, diisopropanolamine, diethylene glycol monobutyl ether, dioctyl sodium sulfosuccinate, self-emulsifying glyceryl monostearate, distearin Polyethylene glycol acid, dicetyl phosphate, sodium dibnate, sucrose fatty acid ester, lipophilic glyceryl monooleate, lipophilic glyceryl monostearate, potassium hydroxide, sodium hydroxide, hydrogenated soybean phospholipid, hydrogenated lanolin alcohol Squalene, squalane, stearyl alcohol, stearic acid, potassium stearate, sodium stearate, polyoxyl 40 stearate, purified soy lecithin, purified lanolin, refined Egg yolk lecithin, sorbitan sesquioleate, cetanol, sodium cetyl sulfate, cetostearyl alcohol, cetomacrogol 1000,
Diethyl sebacate, gelatin, D-sorbitol, sorbol 200, solpol 2242, sorbol 25
39A, Solpol 2500A, Solpol 2540
A, Solpol 2676-S, Solpol 2720, Solpol 2721, Solpol 2850A, Solpol 2852, Solpol 2942-S, Solpol 294
4-S, Solpol 3006-K, Solpol 3006
A, Solpol 3006DB, Solpol 3008-
K, Solpol 3008A, Solpol 3080, Solpol 3269, Solpol 50, Solpol 900
A, Solpol 900B, Solpol AC-2357
A, Solpol AC-2411A, Solpol AC-2
721A, Solpol AE102, Solpol M224
2, Solpol SM-100P, Solpol SM-10
0S, Solpol SM-200, Solpol TM2, Soy Lecithin, Talc, Calcium Carbonate, Medium Chain Fatty Acid Triglyceride, Neutral Sodium Sulfate, Polyoxyethylene Sorbite Tetraoleate, Dehimulus E, Kerosene, Toxanone V1D, Toxanone XK-30, Dodecylbenzene sulfonic acid, polyoxyethylene glyceryl triisostearate, polyoxyethylene glycerin triisostearate (3EO), triethanolamine, sorbitan trioleate, polyoxyethylene sorbitan trioleate (20EO), Sorbitan tristearate, Nikkor PBC-14, Nikkor wax 220, emulsifier AC2338A, Newcargen 1015, Newcargen 1015-P, Newcargen 1066 , Newkalgen 1070, NEWKALGEN 1071, NEWKALGEN 1500TE1,
New Cargen 1585TE1, New Cargen 161
6-D1, Newcargen 1616-D6, Newcargen 1616M, Newcargen 165, Newcargen 185-K4, Newcargen 1880SB, Newcargen 204, Newcargen 2119-K, Newcargen CP-120, Newcargen EP3, Newcargen KH-13, Newcalgen KH-15, Newcalgen KH-20M, Newcalgen KH-25,
New Calgen KL-13, New Calgen KL-20
M, New Calgen KL-26, New Coal NN1
5, New Paul LB-65, Heimar 212, Heimaru CX-8C, Heimaru PS-90A, paraffin,
Nonionic self-emulsifying wax, hydroxypropylcellulose, propylene glycol, propylene glycol fatty acid ester, pectin, hostaphat KW-3
40, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene alkyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene oleyl ether, sodium polyoxyethylene oleyl ether phosphate, polyoxyethylene stearyl ether Polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene cetyl ether, sodium polyoxyethylene cetyl ether phosphate (5EO), polyoxyethylene sorbit beeswax, polyoxyethylene sorbit beeswax (6
E. FIG. O. ), Polyoxyethylene castor oil, polyoxyethylene behenyl ether, polyoxyethylene behenyl ether (20EO), polyoxyethylene (1
60) polyoxypropylene (30) glycol, polyoxyethylene lauryl ether, polyoxyethylene lanolin, polysorbate 40, polysorbate 60,
Polysorbate 65, Polysorbate 80, Macrogol 20000, Macrogol 300, Macrogol 40
0, myristyl alcohol, isopropyl myristate, octyl dodecyl myristate, methyl cellulose, methyl naphthalene, α-monoisostearyl glyceryl ether, sorbitan monooleate, polyethylene glycol monooleate, polyoxyethylene sorbitan monooleate (6E.O. ), Ethylene glycol monostearate, glyceryl monostearate,
Sorbitan monostearate, propylene glycol monostearate, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene sorbitan monostearate (6EO), sorbitan monopalmitate, polyethylene glycol monolaurate (10E) .O.), Polyoxyethylene sorbitan monolaurate (20E.O.).
O. ), Medicated soap, coconut fatty acid, coconut fatty acid diethanolamide, sodium N-lauroyl-L-glutamate, lauromacrogol, lauromacrogol (6
E. FIG. O. ), Lauromacrogol (9EO), egg yolk oil, egg yolk phospholipid, liquid paraffin, decaglycerin fatty acid ester, pentaerythritol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene phytostanol, polyoxyethylene lanolin alcohol・ Beeswax derivatives, polyoxyethylene alkylamines ・ fatty acid amides, polyoxyethylene alkylphenylformaldehyde condensates, alkyl sulfates, polyoxyethylene alkyl ether sulfates, N-acyl amino acids and their salts, N-acylmethyl taurine salts, poly Oxyethylene alkyl ether acetate, alkyl sulfocarboxylate, α-olefin sulfonate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, alkyl ammonium , Alkyl benzyl ammonium salt, betaine, imidazolinium betaine,
Reticin, fatty acid esters, polyhydric alcohol fatty acid esters, alkyl glyceryl ethers and fatty acid esters, higher alcohols, hydrocarbons, natural animal and vegetable oils, vitamin derivatives, glycyrrhizic acid, glycyrrhetinic acid and its derivatives, and the like can be added.

The aqueous pressure-sensitive adhesive composition of the present invention is used as an external preparation. For example, when it is used as a compress sheet, the above-mentioned components and, if necessary, other components are mixed with water and mixed well. Into a paste, which is then
It is applied to the backing of woven fabric, non-woven fabric, plastic film and the like, and if necessary, coated with facing such as polyethylene film and polypropylene film to make the product. Such a material of the backing and facing can be appropriately selected. For example, when a nonwoven fabric is used as the backing, its elasticity is described in, for example, JP-A-3-161431 and JP-A-3-161433. The recovery rate in the length direction of the external preparation is 30% or more, particularly 40% or more, and the recovery rate in the width direction is 40% or more when expressed by the elongation recovery rate at 50% elongation obtained by the method described above. It is preferable to use a nonwoven fabric of 50% or more, especially when the external preparation is adhered to the skin, since the followability to the bending of the joint is particularly good. In the case where a polypropylene film is used as the facing, for example, a material having flexibility and having an ND-type embossed surface on its surface is preferable. Considering the handling of the film, the temperature is 20 ± 2 ° C. and the humidity is 6
At 5 ± 5%, the thickness is about 0.1 ± 0.07 mm,
The specific gravity is about 25 ± 3 g / m ² , and the tensile strength described below is 0.8 kgf / cm or more in the direction corresponding to the length direction of the film product, and 0.6 kgf in the direction corresponding to the same width direction. / Cm or more, and the elongation is 200% or more in the direction corresponding to the length direction as a film product,
A film of 280% or more in the direction corresponding to the same width direction is preferable.

A test sample having a product width of 100 cm was taken from the tensile strength film product, and a length of 50 mm in the measurement direction was obtained from the test sample.
Five test specimens each having a width of 10 mm were sampled in each test direction, and the test specimens were attached to both grips of a tensile tester so that the grip interval was 50 mm.
Pull at 00 mm / min, apply tensile load until the test piece is cut, find the maximum load (tensile strength; kgf / cm) until each test piece is cut, and average the five test pieces Ask for. 50 mm length in the measurement direction and 10 mm in the width direction from the elongation test sample
mm of test specimens in each test direction, and a mark is formed at the center of each test piece in the longitudinal direction so that the distance between the reference points is 40 mm. Attach to both grips so that the grip distance is 50 mm, then pull each test specimen at a pulling speed of 500 mm / min, measure the distance between the gauges at the time of cutting, and measure the gauges of five specimens in each direction. The average value of the distances is obtained, and the elongation percentage in each direction is calculated by the following equation.

[0029]

(Equation 1)

[0030]

The aqueous pressure-sensitive adhesive composition of the present invention is obtained by mixing a substance imparting a refreshing sensation and essential oils and / or extracts having a diuretic action extracted from a specific plant into an aqueous pressure-sensitive adhesive base. Accordingly, when applied to the skin as an external preparation, an aqueous pressure-sensitive adhesive composition having not only a high edema suppressing effect but also excellent safety without causing skin pain or redness can be obtained. Thus, the substance that imparts a refreshing sensation, chamomile, sage, parsley, rosemary, sycamore, anchovy, cornflower, anise, laurel,
One or more essential oils and / or extracts having a diuretic action selected from the group consisting of angelica, fennel, lavender, and thyme extract are blended in an aqueous adhesive base as an edema-improving agent. The aqueous pressure-sensitive adhesive composition of the present invention is particularly useful as a composition used on the skin for the purpose of improving edema.

[0031]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Examples 1 to 9 and Comparative Examples 1 to 9
The components shown in (1) and (2) were mixed and stirred by a Henschel mixer according to a conventional method to prepare an aqueous pressure-sensitive adhesive composition, which was uniformly applied on a nonwoven fabric so as to have a concentration of 700 ± 100 g / m ² , and facing a polyethylene film. To produce a patch. Using each patch, the following carrageenan foot edema test and patch test were performed. The results are shown in Tables 1 and 2.

<Carrageenin foot edema test> Weight 140-1
Using a group of 10 male Wistar rats of 60 g each, the paw volume of the right hind limb of each rat was measured with a volume differential meter, and then 0.1 ml of a 1% carrageenin suspension was used as an anti-inflammatory agent and subcutaneously in the same footpad. Injected. Each patch was applied to the right hind limb 4 hours before the injection of the above-mentioned pneumonia. The foot volume of the right hind limb after the injection was measured with the above-mentioned meter, and the edema rate and the edema inhibition rate of each patch were determined from the difference in the foot volume before and after the injection by the following formula. The patch applied during the test was covered with a black cloth bag from the rat's head to the forelimbs so that the rat would not bite or lick. For comparison, a similar test was performed for a control group to which no patch was applied 4 hours before injection. Edema rate (%) = [(Vt−Vn) / Vn] × 100 Vn: Paw volume before carrageenin injection Vt: Paw volume 4 hours after carrageenin injection Edema inhibition rate (%) = [(Ec−Et) / Ec ] X 100 Ec: average edema rate of control group Et: average edema rate of patch application group

<Patch Test> The patches of the above Examples and Comparative Examples were applied to the upper arms of 20 healthy males, respectively.
The skin irritation of each patch was examined by a 24-hour closed patch test, and the sensory evaluation was performed based on the following evaluation criteria. Evaluation criteria: ○: no irritation ×: irritation

[0035]

[Table 1]

[0036]

[Table 2]

From the results shown in Tables 1 and 2, it is clear that the aqueous pressure-sensitive adhesive composition of the present invention can obtain an excellent edema suppressing effect and does not irritate the skin when applied to the skin as a patch. Admitted. On the other hand, when only a substance that imparts a refreshing sensation is added to the aqueous adhesive base (Comparative Example 1), a satisfactory edema-suppressing effect cannot be obtained, and essential oils and extracts having a diuretic effect in the aqueous adhesive base In the case of mixing only (Comparative Examples 2 to 9), it was recognized that a satisfactory edema suppressing effect could not be obtained or that irritation to the skin occurred. In the above patch test, when the adhesiveness of each patch was observed, the patch of Comparative Example 9 had liquid dripping, stickiness, peeling of the patch, and the like, but Examples 1 to 9 and Comparative Examples The patches Nos. 1 to 8 did not have such a problem and had good adhesiveness.

Next, the following tests were performed on the patches of Examples 1 to 9. When the aqueous pressure-sensitive adhesive layers of the patches of Examples 1 to 9 were visually observed, no bubbles of 5 mm or more in the major axis direction were observed in any case. With nonwoven at one end of the peelable Examples 1-9 of the patch vertically, after shaking in the lateral direction, were macroscopically observed the state of facing, facing is peeled off from the aqueous pressure-sensitive adhesive layer in either case Or, the phenomenon of shifting does not occur, furthermore, after confirming that the above-mentioned phenomenon does not occur, when peeling the facing from the aqueous adhesive layer, the aqueous adhesive composition on the facing side in any case Nothing remained. In the back of the hand peeled facing the adhesive patch of cohesion Examples 1-9, which was affixed to a clean back of the hand of healthy adult, the aqueous adhesive composition at the time of peeling from the bonding part of the adhesive patch after the 20 minutes When the residual amount was measured, the residual area with respect to the applied area was 20% or less in any case, and the residual weight with respect to the applied weight of the aqueous pressure-sensitive adhesive composition was 10% or less. Peel the facing of the patch of anchorage Examples 1 to 9 and paste it on the back of a clean hand of a healthy adult, and after 20 minutes, peel off the patch from the sticking part with the aqueous pressure-sensitive adhesive composition and nonwoven fabric. When the degree of separation was visually observed, no separation between the aqueous pressure-sensitive adhesive composition and the backing was observed in any case. After sealed in the adhesive preparation of extraction of Examples 1 to 9 in the inner bag, the adhesion of the aqueous adhesive composition to the degree and the inner bag of the bond between the patch and the inner bag opening the side of the inner bag When the degree was measured, in each case, the degree of bonding between the patch and the inner bag was 20% or less with respect to the contact area between the patch and the inner bag, and the degree of adhesion of the aqueous pressure-sensitive adhesive composition was , Based on the total weight of the aqueous pressure-sensitive adhesive composition. PH of the aqueous pressure-sensitive adhesive composition About 10 g of the aqueous pressure-sensitive adhesive composition portion was collected from the patches of Examples 1 to 9, and 100 ml of purified water was added thereto.
After applying ultrasonic waves for minutes, the pH of the resulting solution was measured with a pH meter.
-8.

Examples 10 to 12 Each component shown in Table 3 was mixed and stirred with a Henschel mixer according to a conventional method to prepare an aqueous pressure-sensitive adhesive composition. Was applied to produce a patch. Using each patch, a carrageenan paw edema test and a patch test were performed in the same manner as in Examples 1 to 9 and Comparative Examples 1 to 9 described above. The results are also shown in Table 3.

[0040]

[Table 3]

Continuation of the front page (56) References JP-A-6-135828 (JP, A) JP-A-59-212429 (JP, A) JP-A-59-53411 (JP, A) JP-A-6-157327 (JP) , A) JP-A-64-83024 (JP, A) JP-A-62-59219 (JP, A) JP-A-59-110617 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB Name) A61K 9/70

Claims (5)

(57) [Claims] (1) a substance which imparts a refreshing sensation, and (B)
Chamomile, sage, parsley, rosemary, sycamore, sycamore, cornflower, anise, laurel, angelica, fennel, and at least one diuretic essential oil and / or extract selected from the group consisting of extracts from thyme; A water-based pressure-sensitive adhesive composition, characterized by being mixed with a water-based pressure-sensitive adhesive base. 2. The method according to claim 1, wherein the substance (A) for imparting a refreshing feeling is l
Essential oils containing menthol and / or 1-menthol, N-substituted-p-menthan-3-carboxamide, 3
The aqueous pressure-sensitive adhesive composition according to claim 1, which is at least one selected from the group consisting of -substituted-p-menthane, 2- or 3-substituted-p-menthanediol, trialkyl-substituted cyclohexanecarboxyamide, and isopulegol. 3. The compounding ratio (weight ratio) of (A) the substance imparting a refreshing sensation to (B) the essential oils and / or extracts having a diuretic effect is (A) :( B) = 1. : 0.001
The aqueous pressure-sensitive adhesive composition according to claim 1 or 2, wherein 4. The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the aqueous pressure-sensitive adhesive base contains a crosslinked product of polyacrylic acid and a polyacrylate. 5. A substance for imparting a refreshing sensation, chamomile,
One or more essential oils and / or extracts having a diuretic action selected from the group consisting of sage, parsley, rosemary, sycamore, antelope, cornflower, anise, laurel, angelica, fennel, lavender, and thyme extract A water-based pressure-sensitive adhesive composition, characterized in that is mixed with an aqueous pressure-sensitive adhesive base as an edema improving agent.