JP3550139B2 - Allergen remover - Google Patents

Description

【００４５】
〔式中、Ｒ^７及びＲ^１２は、それぞれ炭素数５〜１６、好ましくは６〜１４のアルキル基又はアルケニル基、好ましくはアルキル基であり、Ｒ^９、Ｒ^１０は、それぞれ炭素数１〜３のアルキル基又はヒドロキシアルキル基である。Ｔは−ＣＯＯ−、ＯＣＯ−、−ＣＯＮＨ−、−ＮＨＣＯ−、
【００４６】
【化２】

【００４７】
である。ｇは０又は１の数である。Ｒ^８は、炭素数１〜６のアルキレン基、又は−（Ｏ−Ｒ^１７）_ｎ−である。ここでＲ^１７はエチレン基もしくはプロピレン基、好ましくはエチレン基であり、ｎは１〜１０、好ましくは１〜５の数である。Ｒ^１１は炭素数１〜５、好ましくは２又は３のアルキレン基である。また、Ｒ^１３、Ｒ^１４、Ｒ^１５、Ｒ^１６はこれらの内２つ以上（好ましくは２つ）は炭素数８〜１２のアルキル基であり、残りが炭素数１〜３のアルキル基又はヒドロキシアルキル基である。さらにＺ⁻は陰イオン基、好ましくはハロゲンイオン、炭素数１〜３のアルキル硫酸イオンである。〕
本発明の最も好ましい陽イオン界面活性剤として下記のものを挙げることができる。
【００４８】
【化３】

【００４９】
本発明では界面活性剤として、非イオン界面活性剤が好ましく、特に一般式（２）の化合物が組成物の外観及び貯蔵安定性の点から最も好ましい。
【００５０】
＜（ｆ）成分＞
本発明では通常液体組成物の貯蔵安定性の改善や粘度調整を目的に、本発明の効果を妨げない程度に（ｆ）成分としてハイドロトロープ剤や粘度調整剤を含有しても差し支えない。ハイドロトロープ剤としては炭素数１〜３のアルキル基が１〜３個置換したベンゼンスルホン酸又はその塩を用いることが可能である。また、粘度調整剤としては増粘剤として部分架橋ポリアクリル酸、ヒドロキシエチルセルロース、カルボキシメチルセルロース、キサンタンガム等の配合を検討するとができる。また減粘剤としてポリエチレングリコール（分子量＝３００〜４０００）、ポリプロピレングリコール（分子量＝３００〜２０００）、グリセリン、ポリグリセリン（縮合度２〜１０）、ソルビトール、ペンタエリスリトール等の配合を検討してもよい。
【００５１】
＜その他の成分＞
その他任意成分としては、後述するｐＨ調整剤としての酸やアルカリ剤、メタノールの他、特開平４−９１１９７号公報記載のグリコール系溶剤、特開平７−２２４２９９号公報記載のフェニルエーテル系溶剤、及び特開平７−３２８９号公報記載のグリセリルエーテル系溶剤記載等の（ａ）成分以外の水溶性有機溶剤、アレルゲン除去剤自体を着色するための色素、アレルゲンを被覆することでその発現を抑制するポリマー、アレルゲンを変質されるアレルゲン変性剤、殺菌・殺ダニ剤、並びにアレルゲン除去剤自体に菌やカビの発生を抑制するための防菌・防カビ剤、エアゾールとして配合する場合はプロペラント等を挙げることができるが、（ｂ）成分からの固体生成を抑制する物質の配合量は十分検討されるべきであり、また剤自体がアレルゲン症状を示すことが懸念される物質の配合は控えるべきである。なお、ｐＨを調整する上で、アルカリ金属水酸化物や、硫酸などを含有してもよいが、そのイオンは（ｂ）成分として算入される。また、本発明において（ａ）成分、（ｄ）成分、（ｅ）成分、メタノール、及びエアゾールの有機性のプロペラント以外の有機化合物は（ｇ）成分と称するものとする。
【００５２】
なお、本発明において、乾燥により析出する固体は、（ｂ）成分由来の無機固体以外であってもかまわないが、対象表面からの剥離性を考慮すると、（ｂ）成分を主とするものが好ましい。
【００５３】
＜アレルゲン除去剤＞
本発明のアレルゲン除去剤は、（ｂ）成分及び必要ならば（ｄ）成分や任意成分を（ａ）成分及び（ｃ）成分である水、更に必要に応じて溶剤に溶解させた溶液、好ましくは水溶液の形態である。特に本発明は（ｂ）成分が重要であり、（ｂ）成分は、乾燥に伴い無機塩等の固体を析出させ、対象物表面からアレルゲン物質を収集して剥離させる機能を有する。具体的には、本発明のアレルゲン除去剤を対象物に噴霧処理又は浸漬処理し乾燥させると、対象物表面に（ｂ）成分の陽イオン及び陰イオンを対イオンとする無機固体が析出する。このとき、ダニ類などの生物及びそれらの死骸や糞等のアレルゲン物質を抱き込みながら無機固体が析出する。これをタオルなどの布帛で拭き取ったり、掃除機などの清掃道具を用いて除去することにより、アレルゲンを容易に除去することが可能になる。（ｂ）成分の含有量は、（ｂｃ）成分及び（ｂａ）成分の合計がアレルゲン除去効果を発揮するため、０．００５質量％以上、好ましくは０．０１質量％以上、より好ましくは０．１質量％以上であり、処理表面の感触への影響を考慮して、１０質量％まで配合することができる。しかしながら（ｂ）成分由来の固体物質の対象表面の残留を抑制するためには、好ましくは５質量％以下、より好ましくは３質量％以下である。なお、（ｂｃ）成分のアレルゲン除去剤中の濃度は、原子吸光法で直接定量することができ、また、（ｂａ）成分のアレルゲン除去剤中の濃度は、イオンクロマトグラフィーで測定することが可能である。また、（ｂ’）成分のアレルゲン除去剤中の濃度も同様である。
【００５４】
また、本発明では、固体生成の上で、（ｂｃ）／（ｂａ）＝０．３〜３．０（モル比）が好ましく、より好ましくは０．８〜２．５、特に好ましくは１．０〜２．０である。さらに（ｂｃ）成分及び水素イオン以外の陽イオンが本発明のアレルゲン除去剤中に存在すると対象物表面への無機固体の析出に大きく影響し、著しく効果を減ずるため、このような陽イオンはアレルゲン除去在中に好ましくは０．５質量％未満、より好ましくは０．１質量％未満である。
【００５５】
本発明では、製品の形態としてエアゾール噴霧器を用いる事が出来るが、二酸化炭素をプロペラントとした場合に、多量の二酸化炭素が液中に溶解して液中の（ｂｃ）／（ｂａ）モル比に影響を及ぼす場合がある。この場合は製品が用いられる現実の環境である空気による大気圧下・常温にて（ｂｃ）／（ｂａ）モル比が本発明の範囲内にあることが重要である。（ｂｃ）成分および（ｂａ）成分の定量にあたっても同様の注意が必要である。なお、エアゾール噴霧器を用いる場合において、プロペラントとして液体プロパンガス、液化ブタンガス、ジメチルエーテル等の有機性の化合物を用いる場合は、アレルゲン除去剤の組成物の構成成分として算入しないものとする。
【００５６】
本発明の（ａ）成分は（ｂ）成分の機能を促進させるために用いられる。すなわち（ａ）成分は、噴霧や塗布後の乾燥を促進し、（ｂ）成分に由来する無機固体の対象物表面への析出を促進させる目的で用いられる。このような効果を得るために本発明では（ａ）成分の含有量はアレルゲン除去剤中１〜７０質量％、好ましくは５〜６０質量％、特に好ましくは５〜４０質量％であるが、任意成分として疎水性の有機固体を含有する場合、６０質量％まで考慮してもよい。
【００５７】
また、本発明の（ｄ）成分は、組成物を賦香する目的だけではなく、本発明のアレルゲン除去効果を向上させることができるために、本発明のアレルゲン除去剤に含有させることが好ましい。（ｄ）成分の好ましい含有量は０．００１〜１質量％、より好ましくは０．００１〜０．５質量％、さらに好ましくは０．００１〜０．３質量％である。
【００５８】
本発明では液の外観及び貯蔵安定性の点から（ｅ）成分を含有することができるが、本発明の効果を妨げないことが重要である。また（ｅ）成分は、表面に付着して残留し、効果的な除去が阻害することが懸念される。従って、本発明のアレルゲン除去剤中の（ｅ）成分は、好ましくは１質量％未満、特に好ましくは０．５質量％未満、最も好ましくは０．２質量％以下である。
【００５９】
また、本発明では貯蔵安定性の改善や粘度調整のために（ｆ）成分を含有することが可能であるが、本発明の効果を妨げないことが重要であり、アレルゲン除去剤中に１質量％未満、好ましくは０．５質量％未満、より好ましくは０．２質量％以下である。
【００６０】
さらに、本発明では上記成分以外すなわち、（ａ）成分、（ｄ）成分、（ｅ）成分及び（ｆ）成分に加えて、例外的にメタノールやプロペラント以外の有機化合物〔（ｇ）成分〕、例えば防菌・防かび剤や後述のｐＨ調整剤を含有することができるが、本発明の効果を妨げる恐れがあるため（ｅ）成分、（ｆ）成分、及び（ｇ）成分の合計量が好ましくは５質量％未満、より好ましくは３質量％未満、さらに好ましくは１質量％未満、特に好ましくは０．５質量％未満になるようにすることが好ましい。
【００６１】
（ｃ）成分の水は残部であり、アレルゲン除去剤中に好ましくは３０質量％以上含有する。アレルゲン除去剤は、２０℃におけるｐＨを３〜９、好ましくは４〜８に調整することが好適である。ｐＨ調整剤としては塩酸や硫酸などの無機酸や、クエン酸、コハク酸、リンゴ酸、フマル酸、酒石酸、マロン酸、マレイン酸などの有機酸などの酸剤や、水酸化ナトリウムや水酸化カリウム、アンモニアやその誘導体、モノエタノールアミンやジエタノールアミン、トリエタノールアミンなどのアミン塩など、炭酸ナトリウム、炭酸カリウムなどのアルカリ剤を、単独もしくは複合して用いることが好ましいが、本発明の効果を妨げない程度に種類や量を調整することが重要である。ｐＨ調整剤としては、特に塩酸、硫酸、クエン酸から選ばれる酸と水酸化ナトリウム、水酸化カリウムから選ばれるアルカリ剤を用いることが好ましい。
【００６２】
本発明のアレルゲン除去剤は、好ましくは（ａ）成分、（ｂ）成分、（ｃ）成分と所望により（ｄ）成分の合計が９５〜１００質量％、より好ましくは９８〜１００質量％、最も好ましくは実質的に（ａ）〜（ｄ）成分のみから構成されることが望ましい。
【００６３】
あるいは本発明のアレルゲン除去剤は、好ましくは（ａ）成分を１〜７０質量％、（ｂ’）成分を０．０１〜１０質量％、及び（ｃ）成分を含有し、（ａ）成分、（ｂ’）成分及び（ｃ）成分の合計が９５〜１００質量％である。
【００６４】
本発明のアレルゲン除去剤は対象物への処理のし易さ、及びアレルゲン除去効果を向上させる目的から、アレルゲン除去剤の２０℃における粘度を１５ｍＰａ・ｓ以下、好ましくは１〜１０ｍＰａ・ｓに調整することが好適である。このような粘度に調整することで対象物を均一に処理することができ、さらに乾燥や（ｂ）成分の析出を促進させることができる。本発明でいう粘度は以下のようにして測定する。まずＴＯＫＩＭＥＣ．ＩＮＣ製Ｂ型粘度計モデルＢＭに、ローター番号Ｎｏ．１のローターを備え付けたものを準備する。試料をトールビーカーに充填し２０℃の恒温槽内にて２０℃に調製する。恒温に調製された試料を粘度計にセットする。ローターの回転数を６０ｒ／ｍに設定し、回転を始めてから６０秒後の粘度を本発明の粘度とする。
【００６５】
＜アレルゲン除去方法＞
本発明では、上記アレルゲン除去剤を被対象物に噴霧した後に清掃道具等により前記（ｂ）成分から構成される乾燥時に析出する無機固体等の固体にとり込まれたアレルゲン物質を除去することでアレルゲンを除去する全く新しい方法を提供するものである。すなわち、（ｂ）成分を含有する水溶液をアレルゲンが存在する対象表面に塗布又は噴霧し、乾燥後析出したアレルゲンを包含する前記無機固体等の固体を除去するアレルゲン除去方法を提供する。
【００６６】
噴霧器としては、トリガー式噴霧器、或いはエアゾール式噴霧器を用いることが好ましく、特にはトリガー式噴霧器がより好ましい。
【００６７】
トリガー式噴霧器を用いる場合、該噴霧器は１回のストロークで０．１ｇ〜２．０ｇ、好ましくは０．２〜１．５ｇ、さらに好ましくは０．３ｇ〜１．０ｇ噴出するものが良好である。本発明で使用するトリガー式スプレー容器として特に好ましいものは、実開平４−３７５５４号公報に開示されているような蓄圧式トリガーが、噴霧の均一性の点で特に良好である。
【００６８】
エアゾール式噴霧器を用いる場合、該噴霧器は１秒あたり０．５〜５．０ｇ、好ましくは１秒あたり１．０〜３．０ｇを噴霧するものが良好である。エアゾールの噴射剤としては、液化プロパンガス、液化ブタンガス、ジメチルエーテル、窒素、二酸化炭素、空気などを用いることが出来るが、噴射特性の点からは、液化プロパンガス、液化ブタンガスが好ましく、安全性の点からは窒素、二酸化炭素、空気が好ましい。
【００６９】
噴霧特性としては、特に地面に垂直に置いた対象物に１５ｃｍ離れた場所からスプレーしたときの液のかかる面積が１００〜８００ｃｍ^２、好ましくは１５０〜６００ｃｍ^２になるトリガー式噴霧器が好ましい。また、本発明では（ｂ）成分を対象物１０００ｃｍ^２当たり１〜１０ｍｇ、好ましくは１〜５ｍｇになるように均一に対象物にスプレーし、乾燥させることで高いアレルゲン除去効果を得ることができる。
【００７０】
スプレー後は自然乾燥させた後、タオル等の布帛や掃除機などの清掃道具により対象物を除去することで、アレルゲンを効率的に除去することが可能となる。なお本方法に適した組成は前記した通りである。
【００７１】
なお、本発明のアレルゲン除去剤の対象表面は、カーペット、畳、布製ソファー、ラグ、フローリング床、その他アレルゲンの除去が望まれる住居内の硬質表面、及びふとん、枕、ベッドパッド等の寝具、ぬいぐるみ、布製クッション等を挙げることができる。
【００７２】
本発明のアレルゲン除去剤の最も好ましい処方例とその使用方法を以下に示す。
（Ａ）エタノール、１−プロパノール及び２−プロパノールから選ばれる１種以上 ３〜６０質量％
（Ｂ）カリウムイオン、ナトリウムイオン及びマグネシウムイオンから選ばれる陽イオンと、硫酸イオン及び炭酸イオンから選ばれる陰イオンの組み合わせ（但し、カリウムイオンと炭酸イオンのみの組み合わせは除く） ０．１〜３質量％
（Ｃ）水 残部
（Ｄ）香料 ０〜０．５質量％
（Ｅ）その他の成分 ０〜１．０質量％（但し、界面活性剤濃度は０．２質量％以下）
からなるｐＨ４〜８（２０℃）の水性組成物、更には、該組成物を非エアゾールタイプの噴霧装置を備えた容器に充填したものであって、対象表面から３０ｃｍ離れた位置から、噴霧動作を１回行ったときに、気温２３〜３２℃、湿度６０％ＲＨ以下の環境下において、３０分以内に固体が析出するものである。使い方としては、該水性組成物からなるアレルゲン除去剤を対象表面に噴霧した後、掃除機などで吸引除去することが好ましい。
【００７３】
【実施例】
実施例１
表１に示すアレルゲン除去剤を調製した。下記方法により調製した対象物に下記方法で処理した時のアレルゲン除去効果及び感触を測定した。結果を表１に示す。
【００７４】
（１）アレルゲン除去率の測定
３年間家庭で使用された中古カーペット（（株）サンゲツ製カーペット「サンセシール ＣＬ−１」）を１０ｃｍ四方に裁断した。
【００７５】
裁断したカーペットにサンプルを均一に０．３ｇスプレー（花王（株）製スムーサートリガー容器を用いた。１回のストロークの噴霧量は０．３ｇであり、垂直に置かれた対象面に１５ｃｍ離れた場所からスプレーしたときの液のかかる面積が４２０ｃｍ^２であった）し、室温で３０分間乾燥させた後、新品の紙パックを装着した吸引仕事率２５０Ｗの掃除機で１秒間吸引した。この操作を２０回繰り返した。
【００７６】
その後、ｐＨ７．４±０．１りん酸バッファー液（ＫＨ_２ＰＯ_４、ＮａＣｌ、Ｎａ_２ＨＰＯ_４・７Ｈ_２Ｏをそれぞれ０．１４４ｇ／Ｌ、９．００ｇ／Ｌ、０．７９５ｇ／Ｌとなるように蒸留水に溶解したもの、以下ＰＢＳとする）５０ｍＬを用いて紙パックに捕集されたアレルゲンを抽出した（この抽出液を除去アレルゲン抽出液と呼ぶ）。また、カーペットに残留したアレルゲンを、ＰＢＳ ５０ｍＬを用いて抽出した（この抽出液を残留アレルゲン抽出液と呼ぶ）。
【００７７】
各々の抽出液について、サンドイッチＥＬＩＳＡ法を用いてＤｅｒ ｆ ＩＩ（コナヒョウヒダニ虫体に含まれるアレルゲン）濃度の定量を行った。サンドイッチＥＬＩＳＡ法は以下のように行った。
１．モノクローナル抗体１５Ｅ１１（生化学工業（株））をＰＢＳで２μｇ／ｍｌの濃度に希釈しマイクロプレート（住友ベークライトＥＬＩＳＡ ＰＬＡＴＥ Ｈ ＴＹＰＥ）の各ウェルに５０μｌずつ分注し、室温で２時間静置する。
２．プレートをＰＢＳで３回洗浄する。
３．１％ＢＳＡを含むＰＢＳ（大日本製薬 ブロックエース）を各ウェルに２００μｌずつ分注し室温で１時間静置し、ブロッキングを行う。
４．プレートをＴｗｅｅｎ２０（ＳＩＧＭＡ）を０．０５質量％含有するＰＢＳ（以下、Ｔ−ＰＢＳとする）で３回洗浄する。
５．スタンダードとしてｒＤｅｒ ｆ ＩＩ（生化学工業（株））を０．３μｇ／ｍｌから９管Ｔ−ＰＢＳで２^ｎ倍希釈し、各々５０μｌを各ウェルに分注し、さらに陰性対照としてｒＤｅｒ ｆ ＩＩの替わりにＴ−ＰＢＳを５０μｌ加えたウェルを用意する。測定する試料はＴ−ＰＢＳで適宜希釈してから各ウェルに５０μｌずつ分注する。室温で２時間静置する。
６．プレートをＴ−ＰＢＳで３回洗浄する。
７．至適濃度のＨＲＰ標識１３Ａ４（生化学工業（株））を各ウェルに５０μｌ分注し室温で２時間静置する。
８．プレートをＴ−ＰＢＳで３回洗浄する。
９．ペルオキシダーゼ用発色キットＴ（住友ベークライト）を用いて発色を行う。まず発色剤１０ｍＬに基質液を０．１ｍＬ加えて混和して発色液とする。この発色液を各ウェルに１００μｌずつ分注し室温で発色させる。その後停止液を各ウェルに１００μｌずつ分注して反応を止め、プレートリーダーで４５０ｎｍにおける吸光度を測定する。
１０．スタンダードの吸光度から得られる検量線を用いて測定する試料のＤｅｒ ｆ ＩＩ濃度を算出する。
【００７８】
得られたＤｅｒ ｆ ＩＩ濃度について、除去アレルゲン抽出液のＤｅｒ ｆ ＩＩ濃度をａ、残留アレルゲン抽出液のＤｅｒ ｆ ＩＩ濃度をｂとすると、掃除機吸引によるアレルゲン除去率Ｒは以下の式で定義される。
Ｒ＝ａ／（ａ＋ｂ）×１００ （％）
各サンプルについて上記試験を５回行い、得られた５回分のアレルゲン除去率の平均値を該サンプルのアレルゲン除去率とした。
【００７９】
（２）感触評価方法
（株）サンゲツ製カーペット「サンセシール ＣＬ−１０１」を１０ｃｍ角に切り出した物を試験片として用いた。試験片に対し、０．１ｃｃ／１００ｃｍ^２で処方液をスプレーし、充分乾燥させ、このスプレーと乾燥を５０回繰り返したものをサンプルとした。１０名のパネラーにて、何も処理していない試験片を基準とし、下記基準で官能評価を行い、平均値を求めた。
４…基準よりも感触が良好である
３…基準と同等である
２…基準よりもやや感触が劣る
１…基準よりも明らかに感触が劣る
【００８０】
【表１】

【００８１】
表１中、ノニオン界面活性剤は、アルキルポリグルコシド（アルキル基：炭素数１０／炭素数１２＝４／６（質量比）、グルコース平均縮合度１．３）、アニオン界面活性剤は、アルケニル基の炭素数が１２のアルケニルコハク酸である。（ｂ）は、（ｂ）成分の供給源となる化合物又は（Ｂ’）成分である。
【００８２】
表１中、比較品９は水溶液に調製せず、粉末をそのまま用いた場合の効果について調べたものである。処理方法は、比較品９に示す組成物（固体状）を篩により５００〜１０００μｍに分級した粉末を、裁断したカーペットに５ｇ均一に振りかけ、３０分後に掃除機で吸引した以外は上記と同様の方法でアレルゲン除去効果及び感触を測定した。また、比較品１０は水のみで処理した例である。
【００８３】
なお、表１の組成物を用いず、掃除機のみで処理したカーペットのアレルゲン除去率は２１％、感触評価は３．５であった。
【００８４】
なお、硫酸ナトリウム、硫酸マグネシウム、炭酸ナトリウムの２５℃における溶解度はそれぞれ、２１．９％、２６．７％、２２．７％であり、本願明細書で定義した吸湿性試験はすべて０〜０．５の範囲内である。
【００８５】
実施例２
表２に示すアレルゲン除去剤を調製し、実施例１と同様の方法でアレルゲン除去効果及び感触を測定した。結果を表２に示す。
【００８６】
【表２】

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an agent and a method for effectively removing an allergen that is difficult to remove by ordinary cleaning, and particularly relates to allergic antigens such as dead mites and feces, mold spores and pollen. The present invention relates to an agent and a method for enabling efficient removal of an allergen as a substance.
[0002]
Problems to be solved by the prior art and the invention
Mites, midges, cockroaches and their carcasses or their feces dusted, broken pet hair, pollen, and mold spores are thought to cause allergic symptoms with these as antigens, The effect of so-called allergens on the human body has become a social problem. In particular, with respect to mites, their reproduction is promoted in exchange for comfort of the indoor environment, and the presence of substances causing allergic diseases such as asthma, atopic dermatitis and allergic rhinitis has become apparent. In particular, mites such as Dermatophagoides pteronyssinus, Dermatophagoides farinae and Dermatophagoides farinae inhabit and proliferate in tatami mats, carpets and other rugs, blankets and beddings such as futons. Not only that, there is high interest in ordinary households as well. Many techniques have been proposed for anti-mite agents and acaricides. For example, Japanese Patent Application Laid-Open No. 9-157116 discloses that phenyl isothiocyanate is contained as an anti-mite component, and a fragrance selected from a sesquiterpene compound, an alicyclic compound or an aromatic compound is contained as a stimulating odor reducing component of phenyl isothiocyanate. Anti-mite agents have been described. However, it is known that dead bodies and feces also become allergens, and detoxification of these allergens is being studied.
[0003]
JP-A-6-279273 discloses a method for removing allergens using a specific compound such as gallic acid or a lower alcohol ester thereof. JP-A-61-44821 discloses an allergen remover containing tannic acid and a specific solvent. JP-A-2000-63207 discloses that a specific solvent is effective for detoxifying allergens.
[0004]
As other techniques relating to allergen removal, JP-A-2000-264837 discloses an organic solvent, a polyphenol such as tannic acid, hydroxyapatite, and an allergen remover containing a compound using at least one selected from cationic surfactants. An agent and a method for releasing into a space into fine particles and removing the allergen by the released particles are described, and further, in a container holding and storing the agent in a liquid, powder, sheet, or honeycomb-shaped carrier. Describes an allergen removal method in which air containing allergen is passed by physical suction and trapped. Similarly, JP-A-2002-128659 describes a method of spraying a solution or dispersion containing a house dust treating agent for inactivating or removing an allergen at a specific spray particle diameter.
[0005]
However, these conventional allergen removal methods or removal agents are referred to as "removal" when the protein is denatured to reduce its binding ability to IgE antibody, which is a cause of allergic onset, and render the protein harmless. It is more correct to call it an allergen denaturant. The publication also describes a method in which the allergen is adsorbed on fine particles such as particles of talc or water-swellable clay, or coated with a polymer compound such as polyvinyl alcohol. In this case, since the allergen or its precursor still remains after the treatment, the effect of the allergen is not sufficiently eliminated. In addition, when repeatedly exposed to denatured allergens by these techniques, the denatured allergen itself becomes a new allergen substance, which may be a factor in the onset of allergy. The publication also proposes a technique relating to collection, but aims at trapping allergens in the space, and does not consider the releasability from the treated surface.
[0006]
On the other hand, it is known that it is effective to carefully clean allergens derived from organisms such as mites, mite dung, pollen, and mold spores using cleaning tools such as a vacuum cleaner. On the other hand, bedding such as rugs such as carpets, blankets and futons cannot be easily removed due to the presence of allergen substances even at the bottom of these beddings. For example, 1m for floor cleaning²Vacuuming for 20 seconds or more per person, and carefully vacuuming once a week for bedding are recommended as methods for efficiently removing mite allergens from indoor environments. It is extremely difficult to go on a daily basis. Therefore, there is a need for a method for efficiently removing allergens by a simple cleaning operation.
[0007]
By the way, as a cleaning agent for carpets where mites inhabit, a powder impregnated with a cleaning liquid is sprayed on the carpet, and then the powder and the carpet are rubbed with a brush, and then the carpet is cleaned by suctioning the powder with a vacuum cleaner. There are known ways to do this. As other carpet detergents, JP-A-53-130704 discloses a lithium salt of a sulfate of a mixed alcohol obtained by blending 80 to 95 parts of lauryl alcohol and 5 to 20 parts of decyl alcohol. The invention of a liquid carpet shampoo composition containing water so that the total solid content of a composition comprising a lithium salt of polyphosphoric acid containing 70 to 85% of P2O5 as a builder is 10 to 40%, Further, it is described that the carpet shampoo diluted with water is sprayed on a carpet, spread on the carpet surface, rubbed by brushing, and vacuum-dried to remove powdered washing residue after drying. JP-A-46-2934 describes a cleaning composition used for a carpet or the like comprising a water-soluble organic surfactant, a higher swellable fatty alcohol and a water-insoluble silicate compound. It is described that the resulting foam is formed on a carpet and the foam disappears and is dried before being treated with a vacuum cleaner. Further, as a commercial carpet cleaner, a product is commercially available which sprays a liquid detergent, polishes it with a polisher, and then sucks the dried powder for cleaning. As described above, a method of applying a powder or a liquid for cleaning a carpet and suctioning the dried powder with a vacuum cleaner or the like is already known. However, these carpet cleanings are not intended for removing allergens, but are for the purpose of removing carpet stains, and therefore have a surfactant or a powdery adsorbent as a main base material. . However, when the purpose is to remove allergens, it is desirable that the concentration of such a solid source be small enough to obtain a sufficient effect. There is a problem that it is easy to remain.
[0008]
Accordingly, an object of the present invention is to efficiently remove, by a simple cleaning operation, organisms such as mites and their allergens, such as mites, and their dead bodies or feces, which are difficult to remove by ordinary cleaning attached to the solid surface, and furthermore, the touch of the object to be treated can be improved. It is an object of the present invention to provide an allergen removing agent and a method for removing allergens, which do not change the allergen.
[0009]
[Means for Solving the Problems]
The present invention provides an allergen-removing agent and an allergen-removing method using a completely new system that has never been known before.
[0010]
That is, the present invention relates to an allergen remover containing the following components (a), (b) and (c).
Component (a): an organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C.
(B) component: an inorganic solid is formed by evaporating a liquid component in the allergen removing agent., At least one selected from alkali metal ions and alkaline earth metal ionsWith inorganic cations (bc), Sulfate ions, carbonate ions and phosphate ions.Combination of inorganic anions (ba). However, combinations of only potassium ions and carbonate ions are excluded.
(C) ingredient: water
[0011]
Further, the present invention contains the following component (a), component (b) and component (c), and the component (b) (bc) / (ba) = 0.3 to 3.0 (molar ratio). The present invention relates to an allergen remover having a content of (bc) component and inorganic cations other than hydrogen ions of less than 0.5% by mass.
Component (a): 1 to 70% by mass of an organic compound which forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C.
Component (b): 0.01 to 10% by mass in total of a cation selected from the following component (bc) and an anion selected from the component (ba).
Component (bc): potassium ion, sodium ion and magnesium ion
Component (ba): sulfate ion and carbonate ion
(C) ingredient: water
[0012]
The present invention also relates to an allergen remover containing the following components (a), (b ') and (c).
Component (a): an organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C.
Component (b '):At least one selected from sodium sulfate, magnesium sulfate, sodium carbonate, and sodium hydrogen carbonateInorganic electrolyte
(C) ingredient: water
[0013]
In the present invention, an allergen generally refers to a causative substance of an allergy, but in the present invention, in particular, mites, chironomids, cockroaches and their carcasses or those whose feces are dusted, broken hair of pets, It refers to dried protein, pollen, and mold spores in pet saliva. The allergen-removing agent of the present invention is effective for removing those allergens of 100 μm or less which are difficult to remove by cleaning.
[0014]
In the present invention, the allergen-removing agent refers to an agent that facilitates removal of an allergen from a target surface by treating with the agent.
[0015]
Further, according to the present invention, the method is applied to an object to be treated in which an allergen is present,An organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C.A liquid allergen remover containing a volatile liquid component, which can be separated from the object with the evaporation of the liquid component.A combination of an inorganic cation of at least one selected from alkali metal ions and alkaline earth metal ions and an inorganic anion of at least one selected from sulfate, carbonate and phosphate ions (provided that The combination of potassium ion and carbonate ion alone is excluded.)A liquid allergen remover that produces an inorganic solid is provided.
[0016]
Further, according to the present invention, an organic compound [component (a)] which forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C., and a liquid in the allergen removing agent Generate inorganic solids by evaporation of components, At least one selected from alkali metal ions and alkaline earth metal ionsWith inorganic cations (bc), Sulfate ions, carbonate ions and phosphate ions.Combination of inorganic anions (ba) (However, combinations of only potassium ions and carbonate ions are excluded. )An allergen-removing agent containing [(b) component] and water [(c) component] is brought into contact with an object to be treated in which the allergen is present, and the allergen is removed together with a solid precipitated by drying the contacted portion. An allergen removal method for removing from an object is provided.
[0017]
According to the present invention, the component (a) includes:At least one selected from sodium sulfate, magnesium sulfate, sodium carbonate, and sodium hydrogen carbonateAn allergen-removing agent containing an inorganic electrolyte [(b ′) component] and water [(c) component] is brought into contact with a treatment object in which the allergen is present, and the allergen is removed together with a solid precipitated by drying the contacted portion. A method for removing an allergen to be removed from the object is provided.
[0018]
According to the present invention,Component (a) and at least one selected from alkali metal ions and alkaline earth metal ionsWith inorganic cations (bc), Sulfate ions, carbonate ions and phosphate ions.Inorganic anion (ba) (However, combinations of only potassium ions and carbonate ions are excluded. )Is a liquid composition in which is dissolved, and a liquid composition in which inorganic solids derived from (bc) and (ba) are produced by removing a liquid component in the liquid composition is brought into contact with an object to be treated in which an allergen is present. And a method for removing an allergen from the object to be treated together with a solid precipitated by drying the contact portion.
[0019]
According to the present invention,Consists of the above component (a) and component (c)By removing liquid componentsA combination of an inorganic cation of at least one selected from alkali metal ions and alkaline earth metal ions and an inorganic anion of at least one selected from sulfate, carbonate and phosphate ions (provided that The combination of potassium ion and carbonate ion alone is excluded.)A method for removing an allergen is provided, in which a liquid composition in which an inorganic solid is generated is brought into contact with a treatment object in which an allergen is present, and the allergen is removed from the treatment object together with the solid precipitated by drying the contact portion.
[0020]
According to the present invention,The component (a),An aqueous solution containing a cation selected from sodium ions and magnesium ions and an anion selected from sulfate ions and carbonate ions is applied or sprayed on the target surface where the allergen is present, and a solid containing the allergen precipitated after drying is applied. An allergen removal method for removal is provided.
[0021]
Further, according to the present invention, ticks, chironomids, cockroaches and their carcasses or those excreted of feces containing the above components (a), (b) and (c), Provided is an agent for removing at least one selected from breaks, pollen, and mold spores.
[0022]
BEST MODE FOR CARRYING OUT THE INVENTION
<(A) component>
The component (a) of the present invention is an organic compound which forms an azeotrope with water and has an azeotropic temperature with water at 1013.25 hPa (760 mmHg) of less than 100 ° C. Association, Maruzen Co., Ltd., page II-147 From the compounds forming an azeotropic mixture with water described in Tables 8 and 43, compounds having an azeotropic temperature of less than 100 ° C, preferably 60 to 90 ° C can be used. By using the component (a) in combination, drying of the object to be treated treated with the allergen removing agent of the present invention is promoted, and generation of a solid derived from the component (b) is promoted. Preferred specific examples of component (a) include ethanol, cyclohexane, 2-butanol, cyclohexanol, cyclohexanone, cyclohexane, toluene, 1-butanol, 2-butanol, 1-propanol, 2-propanol, 1-hexanol, hexane, -Heptanol, 1-pentanol and 2-pentanol can be mentioned, and an alcohol compound having 2 to 7 carbon atoms is preferable. Particularly, ethanol, 1-propanol and 2-propanol are most preferable from the viewpoint of the allergen removing effect.
[0023]
<(B) component, (b ′) component>
The component (b) is the most important component in the present invention. In the present invention, the component (b), At least one selected from alkali metal ions and alkaline earth metal ionsWith inorganic cations (bc), Sulfate ions, carbonate ions and phosphate ions.It refers to a combination with an inorganic anion (ba), and exists in a state of being dissolved in at least one of the component (a) and the component (c) in the allergen removing agent. The component (b) is a combination exhibiting a property of producing a solid derived from the component (b) after drying the solution. That is, the component (b) is a solid source substance that exists as a solution in at least the component (a) or the component (c) in the allergen remover, and generates an inorganic solid by evaporation of the liquid component in the remover. That is, the allergen-removing agent of the present invention produces a solid by evaporation of a liquid component in the allergen-removing agent.
[0024]
The reason for defining the component (b) in this manner is that the feature of the present invention is that a solid is formed after drying. For example, when there are a plurality of compounded compounds, furthermore, as a pH adjustment, If an alkali or acid agent is added or an ion dissociating surfactant or organic acid salt is used in combination, the substance precipitated as a solid may be different from the initially compounded substance. is there. However, the present invention does not deny that an inorganic electrolyte having no deliquescence [component (b ')] is directly blended. Of course, the precipitated inorganic solid may be the same as the inorganic electrolyte. In the present invention, “no deliquescent” refers to a low hygroscopic compound described below.
[0025]
Further, here, the evaporation of the liquid component does not mean that all of the liquid component evaporates, but means an amount of evaporation of the liquid component that is sufficient to generate a solid. That is, the liquid components in the allergen-removing agent of the present invention are mainly the component (a) and the component (c). However, when a small amount of a liquid component having low volatility such as a fragrance described later is contained, they are not necessarily evaporated. There is no. By containing the component (b) exhibiting such properties, the allergen-removing agent of the present invention forms a solid by drying or spraying the treated portion after being sprayed or applied to an object to be treated where the allergen is present. . At that time, it is considered that the efficiency of removing the allergen by cleaning is improved because the solid forms the allergen by carrying the allergen or facilitates the separation of the allergen from the surface of the object.
[0026]
The component (b) is a combination of an inorganic cation and an inorganic anion, and the inorganic compound formed by drying an aqueous solution containing these ions is a solid that does not show deliquescence. It is a combination of anions. In the component (b), the solid that precipitates by drying the allergen-removing agent of the present invention is a substance that generates these inorganic cations and inorganic anions as a substance source (or origin), and precipitates as a hydrate. It is also conceivable. When various types of inorganic ions are mixed, the solid produced is not known, but in the present invention, any combination of inorganic ions for depositing the solid may be used. In the component (b), the inorganic cation is preferably an alkali metal or an alkaline earth metal, and the inorganic anion is preferably at least one selected from a sulfate ion, a carbonate ion, and a phosphate ion. The component (b) is preferably a combination of a cation selected from potassium ion, sodium ion and magnesium ion and an anion selected from sulfate ion and carbonate ion. However, it is difficult to solidify a combination of only potassium ions and carbonate ions, and it is necessary to appropriately use ions other than these. That is, in the present invention, a combination of only potassium ions and carbonate ions is excluded.
[0027]
For this reason, in the present invention, it is assumed that the inorganic electrolyte [(b ') component having no deliquescence, which is dissolved in water in the present invention, generates an inorganic cation and an inorganic anion. And a cation selected from potassium ions, sodium ions and magnesium ions, and an anion selected from sulfate ions and carbonate ions. Is preferably 3 to 9. Further, among these inorganic electrolytes, compounds having a solubility in water at 25 ° C. of 10 to 50% by mass, preferably 15 to 40% by mass, are particularly preferred. The solubility of the inorganic electrolyte is a value obtained by expressing the mass of the inorganic electrolyte contained in 100 g of a saturated aqueous solution in mass%, and is described in Chemical Handbook Basic Edition II, 3rd revised edition, The Chemical Society of Japan, edited by Maruzen II-166 to II- 176. Further, a preferred inorganic electrolyte in the present invention is a compound having a moisture absorption of 0 to 2, more preferably 0 to 1, especially 0 to 0.5 as measured by the following moisture absorption test. Such compounds do not show deliquescence.
[0028]
(Hygroscopic test)
(B) 10 g of an inorganic electrolyte serving as a component supply source is dissolved in 100 ml of water, placed in a stainless steel vat having a length of 20 cm, a width of 16 cm, and a depth of 3 cm, and water is removed with a reduced-pressure drier (temperature at the time of drying is 30 ° C., degree of vacuum 200 mmHg, drying time is one week). The precipitated crystals are pulverized and classified with a sieve to 500 to 1000 μm. 1 g (W1) of this classification is put into a cylindrical glass petri dish having a diameter of 7 cm and a depth of 1.5 cm, and the total mass is measured (W2). Next, the whole mass after being left in a constant temperature room at a humidity of 80% and a temperature of 20 ° C. for 24 hours is measured (W3), and the moisture absorption is determined by the following equation.
Moisture absorption = (W3-W2) / W1
[0029]
(B ') componentNoElectrolysisQuality is, Sodium sulfate, magnesium sulfate, sodium carbonate, sodium bicarbonateIsIn particular, one or more selected from sodium sulfate, magnesium sulfate, and sodium carbonate are preferred.
[0030]
<(C) component>
The component (c) of the present invention is water, which is the remainder of the agent containing the components (a), (b) and other components, but is also a solvent for some of the components (b). Water containing some metal ions (the ions may be the component (b)) may be used, but it is preferable to use ion-exchanged water from the viewpoint of storage stability.
[0031]
<(D) component>
In the present invention, it is optional, but preferably contains a fragrance for the purpose of improving the allergen removing effect. As fragrances, "Perfume Chemistry" (Ryoichi Akahoshi, edited by The Chemical Society of Japan, Industrial Chemistry Series, published on September 16, 1983) and "Synthetic Flavor Chemistry and Product Knowledge" (Genichi Indo, Chemical Daily, Inc. It is possible to use those described in "Practical knowledge of spices and perfumes" (published on March 6, 1996) (by Motoki Nakajima, Sangyo Tosho Co., Ltd., published on June 21, 1995). In the present invention, for the purpose of improving the allergen reduction effect, “attractant, repellent, pheromone” and 2.6 described in “Collection of Well-known and Conventional Techniques (Fragrances), Part 1, Fragrances General”, Section 2.6.4. It is preferable to use one or more kinds selected from "pesticides" described in Section 5.
[0032]
Specific preferred fragrances include camphene, l-menthol, borneol, cedrol, t-butylcyclohexanol, camphor, pt-butylcyclohexanone, maltol, cyclopentadecanone, hinokitiol, caryophyllene oxide, bucoxime (manufactured by Dragoca). ), Dimethylphenylcarbinol, phenylglycol, vanillin, ethylvanillin, benzophenone, methylnaphthylketone, coumarin, muskxylene, muskketone, muskambrette, musktibeten, muskmosken (manufactured by Givaudan), celestride (manufactured by IFF), versalide, Tonalide, dimethylhydroquinone, thymol, trans-benzylisoeugenol, β-naphthol methyl ether, banitrop, benzoic acid, Cinnamic acid, phenylacetic acid, hydrocinnamic acid, isoeugenol acetate, cinnamyl cinnamate, phenylethyl salicylate, methyl anisate, indole, skatole, rosephenone, methyl atolarate, raspberry ketone, heliotropyl acetone, 3-methyl-4- Isopropylphenol, p-chloro-m-xylenol, α-pinene, β-pinene, cis-3-hexenyl benzoate, hexyl benzoate, benzyl benzoate, eugenol, caryophyllene, carvone, geraniol, cis-3-hexenyl salicylate, Hexyl salicylate, santalol, citral, citronellal, citronellol, phenylethyl alcohol, hexylcinnamic aldehyde, benzyl alcohol, menthone, linalool, jasmon, dihydroja Mon, methyl jasmonate, methyl dihydrojasmonate, farnesol, nerolidol, phenoxyethanol, cineol, linalyl formate, cinamic aldecht, isophytol, phytol, ceryl methyl ether, β-damascon, α-damascon, β-yonone, α -Yonone, tetrahydrolinalool, lillal (manufactured by IFF), benzardicht, n-amyl benzoate, isoamyl benzoate, heptyl benzoate, phenylethyl benzoate, n-butyl salicylate, isobutyl salicylate, n-amyl salicylate, salicylic acid Isoamyl, methyl salicylate, benzyl salicylate, benzyl n-butyrate, benzyl isobutyrate, benzyl n-valerate, benzyl isovalerate, benzyl propionate, benzyl hexanoate, octanoate One or more selected from jyl and phenylpropyl alcohol are particularly preferred, and most preferably jasmon, dihydrojasmon, methyl jasmonate, methyl dihydrojasmonate, farnesol, nerolidol, camphene, cedrol, hinokitiol, caryophyllene oxide, bucoxime (Dragoca) Dimethylphenylcarbinol, phenylglycol, coumarin, musk xylene, musk ketone, musk ambrette, musktibeten, musk moskene (manufactured by Givaudan), celestride (manufactured by IFF), versalide, tonalide, dimethylhydroquinone, thymol, trans-benzyl Isoeugenol, β-naphthol methyl ether, banitrop, benzoic acid, cinnamic acid, phenylacetic acid, hydrocinnamic acid, acetic acid At least one selected from isoeugenol, cinnamyl cinnamate, phenylethyl salicylate, methyl anisate, indole, skatole, rosephenone, methyl atolarate, raspberry ketone, heliotropyl acetone, 3-methyl-4-isopropylphenol . In the present invention, such a fragrance component can be used alone, but can also be used as two or more fragrance compositions.
[0033]
In the present invention, it is also preferable to use a natural essential oil extracted from a plant as the component (d) from the viewpoint of improving the allergen removal effect. Natural essential oils include peppermint oil, almond oil, column oil, peppermint oil, spearmint oil, cinnamon oil, allspice oil, clove oil, thyme oil, rosemary oil, lemongrass oil, lemon oil, yuzu oil, lime oil, Grapefruit oil, Mandarin oil, Ajowan oil, Bergamot oil, Laurel oil, Star anise oil, Marjoram oil, Mace oil, Boad rose oil, Palmarosa oil, Lemon Verbena oil, Lemon balm oil, Lavender oil, Rose oil, Orange oil, Cassia oil, Cassie oil Oil, garlic oil, cypress oil, perilla oil, cinnamon oil, camphor oil, cedarwood oil, baturi oil, hinoki oil, hiba oil, rice oil, benny royal oil, resea cuba oil, eucalyptus oil, tea tree oil, ylang ylang oil, Vetiver oil, cananga oil, citronella oil, na Meg oil, pepper oil, sandalwood oil, ginger oil, anise oil, mace oil, mention may be made of fennel oil, and the like.
[0034]
Among them, ylang-ylang oil, orange oil, clove oil, sandalwood oil, spearmint oil, cedarwood oil, thyme oil, tea tree oil, peppermint oil, palmarosa oil, hinoki oil, hiba oil, peppermint oil, penny royal oil, One or more selected from eucalyptus oil, lavender oil, lemongrass oil, lemon oil, rosemary oil, camphor oil, and Ajowan oil are preferred.
[0035]
<(E) component>
Although it is optional in the present invention, a surfactant can be used as the component (e) to the extent that the effects of the present invention are not impaired, and in particular, for the purpose of imparting a transparent appearance to the composition, and / or storage stability. In view of the above, a nonionic surfactant, an anionic surfactant, and a cationic surfactant can be blended. However, since the blending of the surfactant causes a residue on the treated surface, attention must be paid to the type of the surfactant, and the blending amount is also limited.
[0036]
Examples of the nonionic surfactant include compounds represented by the following general formulas (1) and / or (2).
[0037]
R¹-O- (O)_a-H (1)
[Wherein, R¹Is an alkyl or alkenyl group having 8 to 18 carbon atoms, preferably 10 to 16 carbon atoms;²Is an alkylene group having 2 or 3 carbon atoms, and is preferably an ethylene group. a represents a number of 3 to 20, preferably 4 to 15, and particularly preferably 5 to 10 as an average number of added moles. ]
R³− (OR⁴)_bG_c                    (2)
[Wherein, R³Is a linear alkyl group having 8 to 16, preferably 10 to 16, particularly preferably 10 to 14, carbon;⁴Is an alkylene group having 2 to 4 carbon atoms, preferably an ethylene group or a propylene group, particularly an ethylene group, G is a residue derived from a reducing sugar, b is a number having an average of 0 to 6, and c is an average of 1 to 1. The number is 10, preferably 1 to 5, particularly preferably 1 to 2. ].
[0038]
Particularly preferred compounds among the compounds of the general formula (1) include a compound of the following general formula (1-1) and / or a compound of the general formula (1-2).
[0039]
R⁵-O (EO)_d-H (1-1)
[Wherein, R⁵Is a primary linear alkyl group, a branched alkyl group or a secondary alkyl group having 10 to 18 carbon atoms, preferably 10 to 16 carbon atoms. EO is ethylene oxide, and d is 3 to 20 as an average addition mole number. ]
R⁶-O [(EO)_e/ (PO)_f] -H (1-2)
[Wherein, R⁶Is a primary alkyl group having 10 to 18 carbon atoms, preferably 10 to 16 carbon atoms. EO indicates ethylene oxide, and PO indicates propylene oxide. e is an average number of added moles of 3 to 15, and f is an average number of added moles of 1 to 5. The EO and the PO may be added randomly, or the PO may be added after the EO is added, or may be a block adduct such as the reverse. ].
[0040]
In the compound of the general formula (2), G is a residue derived from a reducing sugar, and the reducing sugar as a raw material may be any of aldose and ketose, and triose having 3 to 6 carbon atoms. , Tetroses, pentoses, and hexoses. Specific examples of aldose include apiose, arabinose, galactose, glucose, lyxose, mannose, galose, aldose, idose, talose, and xylose, and examples of ketose include fructose. In the present invention, among these, aldopentoses or aldohexoses having 5 or 6 carbon atoms are preferred, and glucose is most preferred.
[0041]
Examples of the anionic surfactant have an alkyl or alkenyl group having 10 to 18 carbon atoms, such as an alkyl or alkenyl benzene sulfonate, an alkyl or alkenyl sulfate, an α-olefin sulfonate, an α-sulfofatty acid salt, and an α-sulfo fatty acid salt. -Surfactants selected from sulfo fatty acid lower alkyl ester salts or fatty acid salts, alkenyl succinic acids or salts thereof.
[0042]
As the salt, a sodium salt, a potassium salt, a magnesium salt, a calcium salt, an alkanolamine salt, and an ammonium salt are preferable, and a sodium salt, a potassium salt, and a magnesium salt are preferable from the viewpoint of a washing effect.
[0043]
As the cationic surfactant, use of compounds represented by the following general formulas (3) to (5) is also preferable from the viewpoint of allergen removal effect.
[0044]
Embedded image

[0045]
[Wherein, R⁷And R¹²Is an alkyl or alkenyl group having 5 to 16 carbon atoms, preferably 6 to 14 carbon atoms, preferably an alkyl group.⁹, R¹⁰Is an alkyl group having 1 to 3 carbon atoms or a hydroxyalkyl group, respectively. T is -COO-, OCO-, -CONH-, -NHCO-,
[0046]
Embedded image

[0047]
It is. g is a number of 0 or 1. R⁸Is an alkylene group having 1 to 6 carbon atoms, or-(OR¹⁷)_n-. Where R¹⁷Is an ethylene group or a propylene group, preferably an ethylene group, and n is a number of 1 to 10, preferably 1 to 5. R¹¹Is an alkylene group having 1 to 5, preferably 2 or 3 carbon atoms. Also, R^Thirteen, R¹⁴, R^Fifteen, R¹⁶Is an alkyl group having 8 to 12 carbon atoms, and the rest is an alkyl group having 1 to 3 carbon atoms or a hydroxyalkyl group. Further Z⁻Is an anionic group, preferably a halogen ion or an alkyl sulfate ion having 1 to 3 carbon atoms. ]
The most preferred cationic surfactants of the present invention include the following.
[0048]
Embedded image

[0049]
In the present invention, a nonionic surfactant is preferable as the surfactant, and a compound represented by general formula (2) is most preferable in terms of appearance and storage stability of the composition.
[0050]
<(F) component>
In the present invention, for the purpose of improving the storage stability and viscosity of the liquid composition, a hydrotrope or a viscosity modifier may be contained as the component (f) to the extent that the effects of the present invention are not impaired. As the hydrotrope agent, benzenesulfonic acid or a salt thereof in which 1 to 3 alkyl groups having 1 to 3 carbon atoms are substituted can be used. In addition, as the viscosity modifier, it is possible to consider the blending of partially crosslinked polyacrylic acid, hydroxyethyl cellulose, carboxymethyl cellulose, xanthan gum and the like as a thickener. In addition, it is also possible to consider blending of polyethylene glycol (molecular weight = 300 to 4000), polypropylene glycol (molecular weight = 300 to 2000), glycerin, polyglycerin (condensation degree 2 to 10), sorbitol, pentaerythritol, etc. as a viscosity reducing agent. .
[0051]
<Other ingredients>
Other optional components include acids and alkali agents as pH adjusters described later, methanol, glycol solvents described in JP-A-4-91197, phenyl ether solvents described in JP-A-7-224299, and A water-soluble organic solvent other than the component (a) described in JP-A-7-3289, a dye for coloring the allergen-removing agent itself, and a polymer whose expression is suppressed by coating with an allergen , An allergen denaturing agent that alters the allergen, a bactericidal / miticidal agent, and a germicidal / antifungal agent for suppressing the occurrence of bacteria and mold in the allergen removing agent itself, and a propellant when formulated as an aerosol. However, the amount of the substance that suppresses solid formation from the component (b) should be sufficiently studied, Formulation of the substance to exhibit allergen symptoms are concerned should refrain. In adjusting the pH, an alkali metal hydroxide, sulfuric acid, or the like may be contained, but its ion is included as the component (b). In the present invention, components (a), (d), and (e), methanol, and organic compounds other than organic propellants such as aerosol are referred to as component (g).
[0052]
In the present invention, the solid precipitated by drying may be other than the inorganic solid derived from the component (b), but in consideration of the releasability from the target surface, the solid mainly composed of the component (b) may be used. preferable.
[0053]
<Allergen remover>
The allergen-removing agent of the present invention is preferably a solution obtained by dissolving the component (b) and, if necessary, the component (d) and optional components in water as the components (a) and (c) and, if necessary, a solvent. Is in the form of an aqueous solution. Particularly, in the present invention, the component (b) is important, and the component (b) has a function of precipitating a solid such as an inorganic salt with drying, collecting an allergen substance from the surface of an object, and exfoliating the substance. Specifically, when the object is sprayed or dipped with the allergen-removing agent of the present invention and dried, an inorganic solid having the cation and anion of the component (b) as a counter ion is precipitated on the surface of the object. At this time, an inorganic solid precipitates while embracing organisms such as mites and allergen substances such as their dead bodies and feces. Allergen can be easily removed by wiping it with a cloth such as a towel or removing it with a cleaning tool such as a vacuum cleaner. The content of the component (b) is 0.005% by mass or more, preferably 0.01% by mass or more, and more preferably 0.1% by mass because the total of the component (bc) and the component (ba) exerts an allergen removing effect. It is 1% by mass or more, and up to 10% by mass can be blended in consideration of the influence on the feel of the treated surface. However, in order to suppress the residual of the solid substance derived from the component (b) on the target surface, the content is preferably 5% by mass or less, more preferably 3% by mass or less. The concentration of the component (bc) in the allergen-removing agent can be directly determined by an atomic absorption method, and the concentration of the component (ba) in the allergen-removing agent can be measured by ion chromatography. It is. The same applies to the concentration of the component (b ') in the allergen removing agent.
[0054]
In the present invention, (bc) / (ba) = 0.3 to 3.0 (molar ratio) is preferable, more preferably 0.8 to 2.5, and particularly preferably 1. 0 to 2.0. Furthermore, if cations other than the component (bc) and the hydrogen ion are present in the allergen-removing agent of the present invention, it greatly affects the precipitation of the inorganic solid on the surface of the object, and the effect is significantly reduced. During the removal, it is preferably less than 0.5% by weight, more preferably less than 0.1% by weight.
[0055]
In the present invention, an aerosol sprayer can be used as a product form, but when carbon dioxide is used as a propellant, a large amount of carbon dioxide dissolves in the liquid and the (bc) / (ba) molar ratio in the liquid is increased. May be affected. In this case, it is important that the (bc) / (ba) molar ratio is within the range of the present invention at atmospheric pressure and normal temperature by air, which is the actual environment in which the product is used. The same precautions are required for the quantification of the component (bc) and the component (ba). When an organic compound such as liquid propane gas, liquefied butane gas, or dimethyl ether is used as a propellant in the case where an aerosol sprayer is used, it is not included in the composition of the allergen remover composition.
[0056]
The component (a) of the present invention is used to promote the function of the component (b). That is, the component (a) is used for the purpose of promoting drying after spraying or coating, and promoting the precipitation of the inorganic solid derived from the component (b) on the surface of the object. In order to obtain such effects, in the present invention, the content of the component (a) is 1 to 70% by mass, preferably 5 to 60% by mass, and particularly preferably 5 to 40% by mass in the allergen removing agent. When a hydrophobic organic solid is contained as a component, it may be considered up to 60% by mass.
[0057]
In addition, the component (d) of the present invention is preferably contained in the allergen-removing agent of the present invention because it can improve the allergen-removing effect of the present invention in addition to the purpose of flavoring the composition. The preferable content of the component (d) is 0.001 to 1% by mass, more preferably 0.001 to 0.5% by mass, and still more preferably 0.001 to 0.3% by mass.
[0058]
In the present invention, the component (e) can be contained in view of the appearance and storage stability of the liquid, but it is important that the effects of the present invention are not hindered. In addition, there is a concern that the component (e) adheres to the surface and remains, which hinders effective removal. Therefore, the content of the component (e) in the allergen removing agent of the present invention is preferably less than 1% by mass, particularly preferably less than 0.5% by mass, and most preferably 0.2% by mass or less.
[0059]
In the present invention, the component (f) can be contained for the purpose of improving the storage stability and adjusting the viscosity. However, it is important that the effect of the present invention is not impaired. %, Preferably less than 0.5% by mass, more preferably 0.2% by mass or less.
[0060]
Furthermore, in the present invention, in addition to the above-mentioned components, that is, in addition to the component (a), the component (d), the component (e) and the component (f), exceptionally, an organic compound other than methanol or propellant [component (g)] For example, a bactericidal / fungicide or a pH adjuster described below can be contained, but the effect of the present invention may be hindered, so that the total amount of the components (e), (f) and (g) Is preferably less than 5% by mass, more preferably less than 3% by mass, still more preferably less than 1% by mass, particularly preferably less than 0.5% by mass.
[0061]
The water of component (c) is the balance, and is preferably contained in the allergen removing agent in an amount of 30% by mass or more. The allergen remover preferably adjusts the pH at 20 ° C. to 3 to 9, preferably 4 to 8. Examples of the pH adjusting agent include inorganic acids such as hydrochloric acid and sulfuric acid, and acid agents such as citric acid, succinic acid, malic acid, fumaric acid, tartaric acid, malonic acid, maleic acid and other organic acids, and sodium hydroxide and potassium hydroxide. It is preferable to use an alkali agent such as sodium carbonate and potassium carbonate, alone or in combination, such as ammonia and its derivatives, amine salts such as monoethanolamine, diethanolamine, and triethanolamine, but they do not impair the effects of the present invention. It is important to adjust the type and amount to the extent. As the pH adjuster, it is particularly preferable to use an acid selected from hydrochloric acid, sulfuric acid and citric acid and an alkali agent selected from sodium hydroxide and potassium hydroxide.
[0062]
The allergen-removing agent of the present invention preferably has a total of 95 to 100% by mass, more preferably 98 to 100% by mass, of the component (a), the component (b), the component (c) and, if desired, the component (d). Preferably, it is substantially composed of only the components (a) to (d).
[0063]
Alternatively, the allergen-removing agent of the present invention preferably contains 1 to 70% by mass of the component (a), 0.01 to 10% by mass of the component (b ′), and component (c). The total of the component (b ′) and the component (c) is 95 to 100% by mass.
[0064]
The allergen-removing agent of the present invention adjusts the viscosity at 20 ° C. of the allergen-removing agent to 15 mPa · s or less, preferably 1 to 10 mPa · s, for the purpose of improving the allergen-removing effect and the ease of treating the object. It is preferred to do so. By adjusting the viscosity to such a value, the object can be uniformly treated, and further, drying and precipitation of the component (b) can be promoted. The viscosity referred to in the present invention is measured as follows. First, TOKIMEC. The rotor number No. is assigned to a B-type viscometer model BM manufactured by INC. Prepare one equipped with one rotor. The sample is filled in a tall beaker and adjusted to 20 ° C. in a 20 ° C. thermostat. The sample prepared at a constant temperature is set in a viscometer. The rotation speed of the rotor is set to 60 r / m, and the viscosity 60 seconds after the start of rotation is defined as the viscosity of the present invention.
[0065]
<Allergen removal method>
In the present invention, allergen is removed by spraying the allergen-removing agent onto the object, and then removing allergen substances taken into solids such as inorganic solids which are deposited during drying, which are composed of the component (b), using a cleaning tool or the like. To provide a completely new way of removing That is, an allergen removal method is provided in which an aqueous solution containing the component (b) is applied or sprayed onto a target surface where an allergen is present, and solids such as the inorganic solids including the allergen precipitated after drying are removed.
[0066]
As the nebulizer, a trigger nebulizer or an aerosol nebulizer is preferably used, and in particular, a trigger nebulizer is more preferable.
[0067]
When a trigger type sprayer is used, it is preferable that the sprayer emits 0.1 g to 2.0 g, preferably 0.2 to 1.5 g, more preferably 0.3 g to 1.0 g in one stroke. . As a particularly preferable trigger type spray container used in the present invention, a pressure accumulating type trigger disclosed in Japanese Utility Model Laid-Open No. 4-37554 is particularly preferable in terms of spray uniformity.
[0068]
When an aerosol sprayer is used, it is preferable that the sprayer sprays 0.5 to 5.0 g per second, preferably 1.0 to 3.0 g per second. As the propellant for the aerosol, liquefied propane gas, liquefied butane gas, dimethyl ether, nitrogen, carbon dioxide, air and the like can be used, but from the viewpoint of injection characteristics, liquefied propane gas and liquefied butane gas are preferable, and safety points are considered. Thus, nitrogen, carbon dioxide and air are preferred.
[0069]
As the spray characteristics, the area where the liquid is applied when the object placed vertically on the ground is sprayed from a distance of 15 cm is particularly 100 to 800 cm.², Preferably 150-600 cm²Is preferred. Further, in the present invention, the component (b) is set to 1000 cm²A high allergen removal effect can be obtained by spraying and drying the target uniformly at 1 to 10 mg, preferably 1 to 5 mg per target.
[0070]
After the spray is air-dried, the object is removed with a cloth such as a towel or a cleaning tool such as a vacuum cleaner, whereby the allergen can be efficiently removed. The composition suitable for this method is as described above.
[0071]
The target surface of the allergen remover of the present invention includes carpets, tatami mats, cloth sofas, rugs, flooring floors, other hard surfaces in houses where allergen removal is desired, bedding such as futons, pillows, bed pads, and stuffed toys. And cloth cushions.
[0072]
The most preferable examples of the allergen-removing agent of the present invention and the method of using the same are shown below.
(A) at least one selected from ethanol, 1-propanol and 2-propanol 3 to 60% by mass
(B) Combination of a cation selected from potassium ion, sodium ion and magnesium ion and an anion selected from sulfate ion and carbonate ion (however, excluding a combination of potassium ion and carbonate ion only) 0.1 to 3 mass %
(C) Water balance
(D) Perfume 0 to 0.5% by mass
(E) Other components 0 to 1.0% by mass (however, the surfactant concentration is 0.2% by mass or less)
An aqueous composition having a pH of 4 to 8 (20 ° C.), and a container provided with a non-aerosol type spray device, which is sprayed from a position 30 cm away from the target surface. Is carried out once, a solid precipitates within 30 minutes in an environment at a temperature of 23 to 32 ° C. and a humidity of 60% RH or less. It is preferable that the allergen removing agent composed of the aqueous composition is sprayed on the surface of the object and then removed by suction with a vacuum cleaner or the like.
[0073]
【Example】
Example 1
Allergen removers shown in Table 1 were prepared. The allergen removing effect and feel when the object prepared by the following method was treated by the following method were measured. Table 1 shows the results.
[0074]
(1) Measurement of allergen removal rate
Used carpets (carpets manufactured by Sangetsu Co., Ltd. "Sanse Seal CL-1") used at home for 3 years were cut into 10 cm squares.
[0075]
Spray 0.3 g of the sample uniformly on the cut carpet (a smoother trigger container manufactured by Kao Corporation was used. The spray amount per stroke was 0.3 g, and the spray amount was 15 cm away from the vertically placed target surface. When sprayed from the place, the area where the liquid is applied is 420cm²After drying at room temperature for 30 minutes, suction was performed for 1 second by a vacuum cleaner with a suction power of 250 W equipped with a new paper pack. This operation was repeated 20 times.
[0076]
Thereafter, a pH 7.4 ± 0.1 phosphate buffer solution (KH₂PO₄, NaCl, Na₂HPO₄・ 7H₂O is dissolved in distilled water so as to be 0.144 g / L, 9.00 g / L, and 0.795 g / L, respectively, hereinafter referred to as PBS). (This extract is called a removed allergen extract). Allergens remaining on the carpet were extracted using 50 mL of PBS (this extract is referred to as a residual allergen extract).
[0077]
For each extract, the concentration of Der f II (allergen contained in Dermatophagoides farinae) was quantified using a sandwich ELISA method. The sandwich ELISA was performed as follows.
1. Monoclonal antibody 15E11 (Seikagaku Corporation) is diluted with PBS to a concentration of 2 μg / ml, and 50 μl is dispensed into each well of a microplate (Sumitomo Bakelite ELISA PLATE H TYPE) and left at room temperature for 2 hours.
2. Wash plate 3 times with PBS.
3. Blocking is performed by dispensing 200 μl of PBS (Dainippon Pharmaceutical Block Ace) containing 1% BSA into each well and allowing to stand at room temperature for 1 hour.
4. The plate is washed three times with PBS containing 0.05% by mass of Tween 20 (SIGMA) (hereinafter referred to as T-PBS).
5. RDer f II (Seikagaku Corporation) was used as a standard from 0.3 μg / ml in 9 tubes of T-PBS.ⁿDouble-fold dilution is performed, and 50 μl of each is dispensed into each well, and a well to which 50 μl of T-PBS is added instead of rDer f II is prepared as a negative control. The sample to be measured is appropriately diluted with T-PBS and then dispensed to each well in an amount of 50 μl. Let stand for 2 hours at room temperature.
6. Wash plate 3 times with T-PBS.
7. An optimal concentration of HRP-labeled 13A4 (Seikagaku Corporation) is dispensed into each well in an amount of 50 μl, and left at room temperature for 2 hours.
8. Wash plate 3 times with T-PBS.
9. Color development is carried out using a peroxidase color development kit T (Sumitomo Bakelite). First, 0.1 mL of the substrate solution is added to 10 mL of the color forming agent and mixed to obtain a color forming solution. This color developing solution is dispensed into each well in an amount of 100 μl and the color is developed at room temperature. Thereafter, 100 μl of the stop solution is dispensed into each well to stop the reaction, and the absorbance at 450 nm is measured with a plate reader.
10. The Der f II concentration of the sample to be measured is calculated using a calibration curve obtained from the absorbance of the standard.
[0078]
With respect to the obtained Der f II concentration, assuming that the Der f II concentration of the removed allergen extract is a and the Der f II concentration of the residual allergen extract is b, the allergen removal rate R by vacuum cleaner suction is defined by the following equation. You.
R = a / (a + b) × 100 (%)
The above test was performed five times for each sample, and the average value of allergen removal rates obtained for the five times was taken as the allergen removal rate of the sample.
[0079]
(2) Feeling evaluation method
A carpet “Sanse Seal CL-101” manufactured by Sangetsu Co., Ltd. cut into a 10 cm square was used as a test piece. 0.1cc / 100cm for the test piece²Was sprayed and dried sufficiently, and a sample obtained by repeating this spraying and drying 50 times was used as a sample. Sensory evaluation was carried out by 10 panelists on the basis of a test piece that had not been subjected to any treatment, and the average value was determined.
4: The feel is better than the standard
3: Same as the standard
2: Slightly inferior to standard
1: The feel is clearly inferior to the standard
[0080]
[Table 1]

[0081]
In Table 1, the nonionic surfactant is an alkyl polyglucoside (alkyl group: carbon number 10 / carbon number 12 = 4/6 (mass ratio), the average degree of glucose condensation 1.3), and the anionic surfactant is an alkenyl group. Is an alkenyl succinic acid having 12 carbon atoms. (B) is a compound serving as a source of the component (b) or the component (B ').
[0082]
In Table 1, Comparative Product 9 was prepared by examining the effect of using a powder as it was without preparing an aqueous solution. The treatment method was the same as above except that the composition (solid state) shown in Comparative Product 9 was sieved and the powder classified into 500 to 1000 μm was uniformly sprinkled on a cut carpet by 5 g and suctioned by a vacuum cleaner 30 minutes later. The allergen removal effect and feel were measured by the method. In addition, the comparative product 10 is an example in which only water is used.
[0083]
In addition, the allergen removal rate of the carpet processed only with the vacuum cleaner without using the composition of Table 1 was 21%, and the feel evaluation was 3.5.
[0084]
The solubility of sodium sulfate, magnesium sulfate, and sodium carbonate at 25 ° C. is 21.9%, 26.7%, and 22.7%, respectively. 5 is within the range.
[0085]
Example 2
Allergen removing agents shown in Table 2 were prepared, and the allergen removing effect and feel were measured in the same manner as in Example 1. Table 2 shows the results.
[0086]
[Table 2]

Claims (18)

An allergen remover comprising the following components (a), (b) and (c).
(A) component: an organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C. (b) component: inorganic component due to evaporation of a liquid component in the allergen remover And an inorganic cation (bc) of at least one selected from alkali metal ions and alkaline earth metal ions, and an inorganic cation of at least one selected from sulfate, carbonate and phosphate ions, which form a solid Combination of sex anions (ba) . However, combinations of only potassium ions and carbonate ions are excluded.
(C) ingredient: water 2. The allergen-removing agent according to claim 1, wherein the component (a) is at least one selected from ethanol, 1-propanol and 2-propanol. The inorganic cation (bc) of the component (b) is a cation selected from a potassium ion, a sodium ion or a magnesium ion , and the inorganic anion (ba) is selected from a sulfate ion, a carbonate ion and a phosphate ion. 1 not less than one, potassium ion and allergen-removing agent according to claim 1 or 2, wherein a combination of only carbonate ions Ru is eliminated that. (Bc) / (ba) of component (b) = 0.3 to 3.0 (molar ratio), and the content of inorganic cations other than alkali metal ions, alkaline earth metal ions and hydrogen ions is 0. allergen-removing agent according to claim 1, wherein less than .5% by weight. The allergen removal according to any one of claims 1 to 4, wherein the component (a) contains 1 to 70% by mass, and the component (b) contains 0.01 to 10% by mass in total of (bc) and (ba). Agent. The allergen removing agent according to any one of claims 1 to 5, wherein the total of the components (a), (b) and (c) is 95 to 100% by mass. It contains the following components (a), (b) and (c), (b) / (ba) of component (b) = 0.3 to 3.0 (molar ratio), and (bc) An allergen remover containing less than 0.5% by mass of inorganic cations other than the components and hydrogen ions.
Component (a): 1 to 70% by mass of an organic compound which forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C.
Component (b): 0.01 to 10% by mass in total of a cation selected from the following component (bc) and an anion selected from the component (ba).
(Bc) component: potassium ion, sodium ion and magnesium ion (ba) component: sulfate ion and carbonate ion (c) component: water An allergen remover containing the following components (a), (b ') and (c).
(A) component: an organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C. (b ′) component: sodium sulfate, magnesium sulfate, sodium carbonate, sodium hydrogen carbonate At least one inorganic electrolyte (c) component selected from : water (B ') component sodium sulfate, magnesium sulfate, allergen-removing agent according to claim 8, wherein at least one selected carbonate sodium or al. It contains 1 to 70% by mass of the component (a) and 0.01 to 10% by mass of the component (b '), and the total of the components (a), (b') and (c) is 95 to 100% by mass. The allergen removing agent according to claim 8 or 9, wherein The allergen-removing agent according to any one of claims 1 to 10, which is provided for a method of removing an allergen together with a precipitated inorganic solid from an object to be treated. A liquid containing a volatile liquid component that is an organic compound that forms an azeotrope with water and has an azeotropic temperature with water at 1013.25 hPa less than 100 ° C. , which is applied to an object to be treated in which an allergen is present. An allergen-removing agent, which is one or more inorganic cations selected from an alkali metal ion and an alkaline earth metal ion, which can be separated from the object to be processed as the liquid component evaporates ; A liquid that forms an inorganic solid using a combination of at least one inorganic anion selected from ions and phosphate ions (however, a combination of only potassium ions and carbonate ions is excluded). Allergen remover. An organic compound which forms an azeotrope with water and has an azeotropic temperature with water at 1013.25 hPa lower than 100 ° C., and an inorganic metal which forms an inorganic solid by evaporation of a liquid component in the allergen removing agent. A combination of an inorganic cation that is at least one selected from ions and alkaline earth metal ions , and an inorganic anion that is at least one selected from sulfate, carbonate and phosphate ions ( however, potassium ion and The combination of only carbonate ions is excluded.) And an allergen-removing agent containing water is brought into contact with the object in which the allergen is present, and the allergen is removed together with the solid precipitated by drying the contact portion. Allergen removal method to remove from the. An organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C., and one or more inorganic electrolytes selected from sodium sulfate, magnesium sulfate, sodium carbonate, and sodium hydrogen carbonate And an allergen-removing agent containing water and an allergen-removing agent, wherein the allergen is removed from the processed object together with a solid precipitated by drying the contacted portion. An organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C .; and an inorganic cation that is at least one selected from alkali metal ions and alkaline earth metal ions. (Bc) and one or more inorganic anions (ba) selected from sulfate ions, carbonate ions and phosphate ions ( however, combinations of only potassium ions and carbonate ions are excluded) are dissolved . A liquid composition in which an inorganic solid derived from (bc) and (ba) is produced by removing a liquid component in the liquid composition, and contacting the liquid composition with an allergen. A method for removing an allergen from the object, together with a solid precipitated by drying the contact portion. An organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C., and is selected from alkali metal ions and alkaline earth metal ions by removing a liquid component composed of water. A combination of one or more inorganic cations and one or more inorganic anions selected from sulfate ions, carbonate ions and phosphate ions (however, a combination of only potassium ions and carbonate ions is excluded. A) a liquid composition in which an inorganic solid having a solid source material as a solid source substance is brought into contact with an object to be treated in which an allergen is present, and the allergen that removes the allergen from the object to be treated together with the solid precipitated by drying the contact portion; Removal method. Forming an azeotrope with water, selected organic compound azeotropic temperature with water is 100 ° C. less than the 1013.25 hPa, and a cation selected from sodium ions and magnesium ions, sulfate ions, carbonate ions An allergen removal method in which an aqueous solution containing an anion is applied or sprayed onto a target surface where the allergen is present, and after drying, a solid including the precipitated allergen is removed. The following components (a), (b) and (c) are contained, and mite, chironomid, cockroach and their carcasses or their feces are dusted, broken pet hair, pollen, and mold An agent for removing at least one selected from spores.
(A) Component: An organic compound that forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C. (b) Component: Inorganic by evaporation of a liquid component in the allergen remover One or more inorganic cations (bc) selected from an alkali metal ion and an alkaline earth metal ion, and one or more inorganic cations selected from a sulfate ion, a carbonate ion and a phosphate ion, which form a solid. Combination of anions (ba) . However, combinations of only potassium ions and carbonate ions are excluded.
(C) ingredient: water