JPS5811926B2 - toothpaste composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition that is highly foamable, has excellent palatability, and is highly safe in use.

Foaming agents are blended into toothpaste compositions to enhance the cleaning power of the abrasives, but since the foaming agents blended into toothpaste are used in the oral cavity, there are safety concerns. Of course it has to be expensive, but
It is preferable to have high foaming properties, excellent detergency, and good permeability, as well as those that improve the taste of toothpaste.In addition, from the product value point of view, products that maintain the shape of toothpaste well and are hard to resist in winter are preferred. It is preferable to use a tube that does not cause the toothpaste to become difficult to push out from the tube.

Therefore, in consideration of the above points, sodium lauryl sulfate, sodium N-lauroyl sarcosinate, etc. have been conventionally used as blowing agents, but sodium lauryl sulfate is not suitable for polyvalent cations such as calcium phosphate, calcium carbonate, calcium sulfate, etc. Foaming properties are inhibited in toothpastes containing bases that release foaming power, and in order to increase foaming power, the amount of foaming must be increased.

In addition, sodium N-lauroyl sarcosinate is 0.5
% or more, it causes a peeling effect on the oral mucosa, and below this, there is almost no foaming and it cannot be used as the main component of a foaming agent.

Furthermore, N-long chain acyl glutamate and sucrose fatty acid ester are known as foaming agents for toothpaste, but although these foaming agents are both highly safe to use, acyl glutamate is similar to sodium lauryl sulfate. Foaming properties are easily inhibited in toothpastes containing polyvalent cation-releasing bases such as calcium phosphate, calcium carbonate, and calcium sulfate.
Furthermore, sucrose fatty acid esters have problems such as poor foaming properties in all systems.

In view of the above circumstances, the present inventors have developed a dentifrice composition, such as a normal toothpaste, which is a multivalent cation-releasing system containing calcium phosphate, calcium carbonate, calcium sulfate, etc. as a base, and which has excellent foaming power and is palatable. In order to find a blowing agent with good properties and high safety, as a result of intensive research, we found that a sucrose fatty acid ester with an acyl group having 12 to 18 carbon atoms and the following general formula (1) [However, Ml and M2 are Either one is an alkali metal group and the other is a hydrogen group, or both are an alkali metal group, and RC
O- is a mixture of coconut oil fatty acid and hydrogenated beef fatty acid in a weight ratio of 1:9 to 3 nia, and an unsaturated fatty acid with an acyl group of 14 to 18 carbon atoms such as oleic acid (however, coconut oil 6 as a weight ratio of fatty acids (excluding unsaturated fatty acids)
Mixed fatty acid residues containing in a ratio of 5:35 to 85:15 are shown.

], and 0.1 to 2 parts by weight, preferably 0.3 to 1.2 parts by weight of sucrose fatty acid ester per 1 part by weight of the N-mixed fatty acid acylglutamate. When used in combination as a foaming agent in a dentifrice composition containing a base that releases polyvalent cations, the synergistic action of both active agents results in excellent foaming power. It was found that the combined use of these agents was superior to the use of sodium lauryl sulfate or sucrose fatty acid ester alone.

That is, the present inventors have discovered that N-long chain acylglutamate (
anionic activators), sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and pluronic activators (nonionic activators), respectively, or in appropriate combinations of anionic activators and nonionic activators. As a result of measuring the foaming power in a suspension system and a gypsum suspension thread, it was found that only the combination of N-mixed fatty acid acylglutamate represented by the above general formula (1) and sucrose fatty acid ester had a certain level of foaming power. We have discovered that when these two active agents are used together in a proportion within the range, they act synergistically and the foaming power is significantly increased, and based on this knowledge, we have developed the present invention. It is.

The present invention will be explained in detail below.

The dentifrice composition according to the present invention contains a base that releases polyvalent cations, and this base includes calcium phosphate such as dicalcium phosphate dihydrate, calcium carbonate,
Alternatively, calcium sulfate such as calcium sulfate dihydrate may be used alone or in combination as appropriate.

The content of the base in the dentifrice composition is not particularly limited, but for example, in toothpaste, it is usually 10 to 80% (wt%).
(the same applies hereinafter), especially 20 to 60%.

In addition, as a base, silicic anhydride or the like may be added in addition to the polyvalent cation-releasing base.

Furthermore, the dentifrice composition according to the present invention may contain various components depending on the type of toothpaste, dentifrice, etc.

For example, in the case of toothpaste, in addition to the above-mentioned bases, moisturizers such as glycerin, sorbitol, and propylene glycol, binders such as carboxymethyl cellulose, sodium alginate, and gum arabic, as well as fragrances, sweeteners, Preservatives, fluorine compounds, antibacterial agents, antienzyme agents, etc. are appropriately added.

The blending amounts of these components are the same as in the case of known toothpastes.

In the present invention, a sucrose fatty acid ester and an N-mixed fatty acid acylglutamate are combined as a foaming agent in a dentifrice composition containing the above-mentioned polyvalent cation-releasing base.

In this case, the sucrose fatty acid ester may be sucrose monopalmitate, sucrose monolaurate, sucrose monostearate, sucrose monomyristate, etc. each having an acyl group of 12 to 18 carbon atoms, or may be used alone or in combination. Used in combination with the above.

In addition, as N-mixed fatty acid acylglutamate, General formula (1) below Use the one shown.

However, one of M1 and M2 is an alkali metal group and the other is a hydrogen group, or both are alkali metal groups, and sodium is usually used as the alkali metal.

In addition, RCO- is a combination of coconut oil fatty acid and hydrogenated beef tallow fatty acid.
This indicates a mixed fatty acid residue containing a mixture formed by mixing at a weight ratio of 9 to 3 nia and an unsaturated fatty acid in a weight ratio of 65:35 to 85:15, and in this case, the unsaturated fatty acid includes an acyl group. Oleic acid, myristoleic acid, linoleic acid, liluic acid, etc. each having 14 to 18 carbon atoms, and especially oleic acid, are used.

Note that the unsaturated fatty acids in coconut oil fatty acids are not included in these unsaturated fatty acids.

The combined ratio of the sucrose fatty acid ester and the N-mixed fatty acid acyl glutamate is 0.1 part by weight of the sucrose fatty acid ester to 1 part by weight of the N-mixed fatty acid acyl glutamate.
~2.0 parts by weight, particularly preferably 0.3 to 1.2 parts by weight.

When the combined ratio of both active agents is within the above range, the polyvalent cation release system has a synergistic high foaming effect and good palatability; however, outside the above range, the foaming power is low. The object of the present invention cannot be achieved.

Incidentally, the total amount of both active agents is 0.5 to 0.5 in the dentifrice composition.
It is preferably 5%, particularly 1 to 3%, and excellent foaming effects can be achieved within this range.

In addition, in the present invention, other anionic, nonionic, etc. activators may be blended with both of the above-mentioned activators.

Therefore, the dentifrice composition according to the present invention is produced by kneading the above-mentioned components with both the active agents, the sucrose fatty acid ester and the N-mixed fatty acid acylglutamate, by a conventional method. A dentifrice composition containing a polyvalent cation-releasing base has a high foaming power due to the synergistic effect of both of the active agents by blending them as foaming agents in the above-mentioned ratios.

That is, sucrose fatty acid ester has almost no foaming power when used alone, and the N-mixed fatty acid acyl glutamate exhibits considerable foaming power in a simple aqueous system, but it does not have foaming power in a calcium phosphate suspension system or calcium sulfate suspension system. Threads that release polyvalent cations, such as suspension-type threads, tend to have lower foaming power, but those that use sucrose fatty acid ester and N-mixed fatty acid acyl glutamate together in the proportions within the above ranges In polyvalent cation release systems such as calcium phosphate, the combined use of these active agents exhibits a synergistic effect and exhibits excellent foaming power.

In addition, when the N-mixed fatty acid acylglutamate is used in combination with sucrose fatty acid ester in a predetermined ratio as described above, its foaming power increases synergistically, but it itself has extremely high permeability (the N- The mixed fatty acid acyl glutamate is a mixed fatty acid residue containing coconut oil fatty acid or hydrogenated beef tallow fatty acid alone, or a mixture of coconut oil fatty acid and hydrogenated beef tallow fatty acid at a ratio outside the range of 1:9 to 3 nia (weight ratio). and oleic acid, an unsaturated fatty acid, in a weight ratio of 65:35 to 85:15.
- It very specifically improves permeability compared to mixed fatty acid acylglutamic acids, etc.) Therefore, the dentifrice composition of the present invention has extremely excellent oral cleaning ability.

In addition, the dentifrice composition according to the present invention has improved palatability compared to a composition containing sodium lauryl sulfate or sucrose fatty acid alone by using both of the above-mentioned active agents, and has an excellent refreshing feeling after use. As a result of taste tests, mixed fatty acid acyl glutamate has been found to have a less bitter taste than sodium lauryl sulfate or N-mixed fatty acid acyl glutamate, which contains a large amount of coconut oil fatty acid. The amount does not necessarily have to be large, and since a nonionic active agent that is less irritating to the skin is added, the taste is better and the juice effect is improved.

Therefore, the dentifrice composition of the present invention has good taste and feel when used.

The N-mixed fatty acid acyl glutamate is N-lauroyl glutamate, N-hardened beef tallow acyl glutamate, mixed fatty acid acyl glutamic acid obtained by mixing only hydrogenated beef tallow and coconut oil, or a mixture of hydrogenated beef tallow and coconut oil. Even if the mixture and unsaturated fatty acids such as oleic acid are mixed, the ratio is outside the range of 65:35 to 85:15 (weight ratio), compared to mixed fatty acid acyl glutamate, etc. The toothpaste composition of the present invention has the characteristic that the consistency of its highly concentrated solution is moderate at a temperature of There are no inconveniences such as difficulty in extruding from the tube, and the product is excellent in terms of product value.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

Experimental Example 1 Sucrose fatty acid ester [P-1570 manufactured by Ryoto Co., Ltd.
``Using sucrose monopalmitate (70% sucrose motubalmitate, 30% sucrose dipalmitate)''
Monosodium N-mixed fatty acid acylglutamate [manufactured by Ajinomoto Co., Inc., acyl group is a mixture of hardened beef tallow fatty acid and coconut oil fatty acid in a weight ratio of 8:2 and oleic acid in a weight ratio of 75:25. Mixed fatty acid residues containing at a ratio of 0.2 to 0.2
The sucrose fatty acid ester concentration was kept constant at 5%, and the ratio of sucrose fatty acid ester/N-mixed fatty acid acylglutamate (weight ratio) was varied. Dihydrate suspension system, 2
% calcium sulfate dihydrate suspension system,
The foaming power of the mixed active agent was investigated using the Ross Miles method.

The results are shown in Figure 1. The results are the foam height after 1 minute at 25°C.

For comparison, the above-mentioned sucrose fatty acid ester, N-mixed fatty acid acyl glutamate, and sodium lauryl sulfate were added individually in different amounts to create an aqueous solution, a 2% dicalcium phosphate dihydrate suspension, and a 2% dicalcium phosphate dihydrate suspension. % calcium sulfate dihydrate suspension system are shown in FIGS. 2, 3, and 4.

In addition, in Figures 1 to 4, △-△ is water system, □-
□ represents the results of the foam height of each active agent in the dibasic calcium phosphate system, and ◯ to ○ in the calcium sulfate system.

As is clear from the results shown in Figures 1 to 4, sucrose fatty acid ester does not exhibit foaming properties in any of the systems;
In addition, the foam height of N-mixed fatty acid acylglutamate decreases in dibasic calcium phosphate systems and calcium sulfate systems compared to aqueous systems, and the foaming power decreases the most especially in calcium sulfate suspensions with a large degree of dissolution. It was thus observed that the foaming power of polyvalent cations was inhibited.

On the other hand, the foaming power of a combination of sucrose fatty acid ester and N-mixed fatty acid acylglutamate is significantly reduced in an aqueous system, and in a system without polyvalent cations, the combination of both active agents results in poor foaming. However, in dibasic calcium phosphate threads and calcium sulfate systems that release polyvalent cations, the ratio of sucrose fatty acid ester to N-mixed fatty acid acylglutamate is 0.1.
~2.0 Especially in the range of 0.3:1.2, the foaming power is significantly increased compared to when both of the above-mentioned activators are used alone, and by using both activators in a fixed ratio in this way, It was found that their synergistic action significantly increases the foaming power.

Moreover, sodium lauryl sulfate is 0.0% in an aqueous system.
It showed a certain high foaming power at a concentration of 3% or more, but the foaming power was considerably lower in dibasic calcium phosphate suspension systems and calcium sulfate suspension systems, which are similar to normal toothpaste systems, compared to aqueous systems. However, it has been found that the concentration of sodium lauryl sulfate must be increased in order to increase the foaming power.

Experimental Example 2 Sucrose monolaurate [hereinafter referred to as A-1 (mixture of 90% sucrose monolaurate and 10% sucrose dilaurate)]]] N-mixed fatty acid acylglutamate monosodium (hereinafter referred to as A) acyl group is a mixed fatty acid residue containing a mixture of hydrogenated beef tallow fatty acid and coconut oil fatty acid in a weight ratio of 8:2 and oleic acid in a weight ratio of 70:30] combination (hereinafter this combination will be referred to as A), and sucrose monostearate [hereinafter referred to as B-1 (a mixture of 70% sucrose monostearate and 30% sucrose distearate)]]]]] Monosodium fatty acid acylglutamate, hereinafter referred to as B (
acyl group is a mixed fatty acid residue containing a mixture of hydrogenated tallow fatty acid and coconut oil fatty acid in a weight ratio of 7:3 and oleic acid in a weight ratio of 85:15] (hereinafter this combination will be referred to as B), the concentration of monosodium N-mixed fatty acid acylglutamate in A-2 and B-2 is kept constant at 0.255, and the concentration in A-1 and B-1 is A-1/A-2 and B-17B by changing the concentration of sucrose fatty acid ester.
-2 ratio changed to 0.5, 1.0°2.0,
Water system, 2% dibasic calcium phosphate dihydrate suspension system,
The foaming power of the mixed active agent was investigated by adding each to a 2% calcium sulfate dihydrate suspension system using the Ross Miles method.

The results are shown in Table 1. The results are the foam height after 1 minute at 25°C.

For comparison, A-1 and B-1 were each used individually at 0.
Aqueous at 5% concentration, 2% dibasic calcium phosphate 2
The foam heights when added to a hydrate suspension system and a 2% calcium sulfate/dihydrate suspension thread were measured and were 2.2 cm and 1.4 cm, respectively, in both systems.

Similarly, when A-2 and B-2 were added alone at a concentration of 0.5% to each of the above groups, the foam height coincided with the results shown in Figure 3 by about 2°Ocm above. It was found that there is a tendency of

Examples are shown below.

Example 1 The toothpaste according to Example 1 above, a toothpaste with a composition excluding N-mixed fatty acid acylglutamate from the above composition (comparative toothpaste A), and a toothpaste with the above composition excluding N-mixed fatty acid acylglutamate and sucrose Regarding a toothpaste with a composition in which 0.8% by weight of sodium lauryl sulfate was added instead of fatty acid ester (comparative toothpaste B), the preference was examined 10 times using the 5cheffe' paired comparison method, taking into account the order effect. The results were as follows.

Example > Comparative toothpaste B >> Comparative toothpaste A Preference level +2.0 +1.5 -3.5 Furthermore, the toothpaste according to the present invention was particularly excellent in foaming properties and refreshing feeling after use.

Example 2 A toothpaste having the following composition was produced by a conventional method.

The toothpaste of Example 2 and the toothpaste with the above composition excluding N-mixed fatty acid acylglutamate (comparative toothpaste A')
) and a toothpaste with the above composition in which 1.2% sodium lauryl sulfate was added instead of N-mixed fatty acid acylglutamate and sucrose fatty acid ester (comparison toothpaste B'). Considering
The foaming properties of each toothpaste were investigated using the 5cheff'e paired comparison method, and the results are as follows.

Example≫Comparative toothpaste B≫ Comparative toothpaste A' Foaming property +3.2 +1.1 -4.3 Furthermore, the toothpaste according to the present invention was particularly excellent in refreshing feeling after use.

Example 3 Similar to Example 1, the toothpastes of Examples 2 and 3 were highly palatable, and had excellent foaming properties and a refreshing feeling after use.

[Brief explanation of drawings]

Figure 1 is a graph showing the measurement results of foam height by the Rothsmiles method in aqueous systems, calcium phosphate threads, and calcium sulfate systems when sucrose fatty acid ester and N-mixed fatty acid acylglutamate are used together; FIG. 4 is a graph similar to FIG. 1 when sucrose fatty acid ester, N-mixed fatty acid acyl glutamate, and sodium lauryl sulfate are used alone.

Claims (1)

[Scope of Claims] 1. In a dentifrice composition containing a base that releases polyvalent cations, a sucrose fatty acid ester with an acyl group having 12 to 18 carbon atoms as a foaming agent and a general formula [where Ml and M2 are One is an alkali gold layer group and the other is a hydrogen group or both are alkali metal groups, and RCO- is a mixture of coconut oil fatty acid and hydrogenated beef tallow fatty acid in a weight ratio of 1:9 to 3 nia and olein. The number of carbon atoms in the acyl group of acids, etc. is 14
~18 unsaturated fatty acids (excluding unsaturated fatty acids in coconut oil fatty acids) in a weight ratio of 65:35 to 85:1
The mixed fatty acid residues contained in the ratio of 5 to 5 are shown. ] is characterized in that the sucrose fatty acid ester is used in combination with the N-mixed fatty acid acylglutamate at a ratio of 0.1 to 2 parts by weight per 1 part by weight of the N-mixed fatty acid acylglutamate. Toothpaste composition. 2. The dentifrice composition according to claim 1, wherein sucrose fatty acid ester is used in combination at a ratio of 0.3 to 1.2 parts by weight per 1 part by weight of the N-mixed fatty acid acylglutamate.