JPS6143327B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention provides a dentifrice composition, more specifically, it has improved foaming properties when using a safer N-long chain acyl glutamate as a foaming agent, and does not change the taste of food after tooth brushing. The present invention relates to a dentifrice composition. Toothpaste compositions contain foaming agents to impart cleaning, dispersing, emulsifying, and foaming effects.
Surfactants are used for that purpose. Surfactants used as foaming agents increase the cleaning effect of toothpaste by lowering the interfacial tension of the toothpaste during use, promote the dispersion and penetration of the medicinal agents contained in the toothpaste, and increase its effectiveness. It can be said to be an essential ingredient as it plays a role such as providing a sense of stability through foaming during use. These surfactants must not only have good performance such as interfacial tension lowering ability and foaming properties, but also satisfy aspects such as taste and odor since toothpaste is something that is put in the mouth. Conventionally, anionic surfactants such as sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate, and sodium coconut monoglyceride sulfate have been used, and sodium alkyl sulfate in particular has excellent performance and taste, but is also generally used. However, it has the major disadvantage that it changes the taste of food after use, which is thought to be caused by adsorption to the taste buds of the tongue and oral mucosa.
There are problems such as slight irritation of the oral mucosa and inactivation of enzymes added as medicinal agents in toothpaste. On the other hand, recently, the safety of these surfactants has become a problem, and various studies have been conducted to use safer surfactants as foaming agents.
As one of these, it has been proposed to incorporate N-long chain acyl glutamate into toothpaste (Special Publication No. 1973-
No. 24480). N-long chain acyl glutamate is non-toxic, has very mild irritation to the skin and mucous membranes, has good cleaning power, foaming power, emulsifying power, and has excellent hard water resistance. It is said to have the following characteristics and is very effective as a foaming agent for dentifrice compositions. However, when this is added to a toothpaste composition, it is usually affected by the base that releases polyhedral cations such as calcium phosphate and calcium carbonate, which are included in the toothpaste composition, resulting in excessive foaming over time after the toothpaste is manufactured. In practice, it is very difficult to incorporate it into such dentifrice compositions because it causes a phenomenon of reduced strength and loses its commercial value. The present inventors conducted various studies from the viewpoint of incorporating a safer foaming agent into a dentifrice composition, and first, they added sodium monofluorophosphate and/or polyphosphate to N-long chain acylglutamate. It was discovered that the foaming power did not decrease when used in combination with the above-mentioned base, and a patent application has already been filed (Japanese Patent Application No. 51-026482). Subsequently, as a result of further studies, it was found that even when sodium acylsarcosinate or sodium N-acyl-N-methyl-β-alanine is used in combination with N-long chain acylglutamate, it does not affect the substrate used. It was discovered that a dentifrice composition having excellent foaming properties can be obtained. That is, the present invention provides a dentifrice composition containing N-long chain acyl glutamate and sodium acylsarcosine or sodium N-acyl-N-methyl-β-alanine as a foaming agent. The composition has excellent foaming properties, does not change the taste of food after tooth brushing unlike conventional dentifrice compositions containing sodium alkyl sulfate, and is highly safe. Table 1 below shows the results of testing the foaming properties of toothpastes using a combination of N-long chain acylglutamate and acylsarcosine or sodium N-acyl-N-methyl-β-alanine. The test was conducted using N-long chain acyl glutamate with acyl groups containing hydrogenated tallow fatty acid residues (14 to 14 carbon atoms).
18), using lauroylsarcosine as the acylsarcosine and N-lauroyl-N-methyl-β-alanine sodium as the N-acyl-N-methyl-β-alanine sodium, according to the recipe in Example 1 below, Foaming amount of dentifrice compositions obtained by varying these blending amounts,
This was done by measuring the volume. The amount of foaming is indicated by the foam volume (ml) after putting 5 g of each toothpaste sample into a mixer, then adding 150 ml of water warmed to 30°C and stirring at 60 V for 90 seconds. The volume was evaluated as follows. ◎: Sufficient foaming 〇: Foaming △: Little foaming ×: Almost no foaming

[Table] Note: *: Weight% (same below)
As is clear from Table 1, monosodium N-long chain acylglutamate, sodium lauroyl sarcosine, N-lauroyl-N-methyl-β
- Sodium alanine hardly foams alone, but when monosodium N-long chain acylglutamate and sodium lauroyl sarcosine or sodium N-lauroyl-N-methyl-β-alanine are used in combination, foaming properties are significantly improved. The acyl glutamate to be used is preferably a monosodium salt of beef tallow fatty acid residue (carbon 14-18) having an acyl group since it has good foaming properties. The foaming property in an aqueous solution is greatest when the acyl group is a lauric acid residue, but the foaming property does not change much in the dentifrice composition. The blending ratio of acylglutamate is appropriately selected depending on the formulation of the dentifrice composition, but is usually preferably in the range of 0.5 to 3%. In addition, the acylsarcosine sodium used, N
Examples of sodium -acyl-N-methyl-β-alaninate include those in which fatty acid residues are lauric acid, myristic acid, palmitic acid, and stearic acid. Both acylsarcosine sodium and N-acyl-N-methyl-β-alanine sodium are highly safe because they are broken down into fatty acids and amino acids even if taken into the body, but acylsarcosine sodium has a concentration of 0.5% or more. ,Also,
In the case of N-acyl-N-methyl-β-alanine sodium, if it is used in an amount of 0.75% or more, oral mucosal peeling will occur, so it is preferably blended in a proportion less than this. The dentifrice composition of the present invention includes all conventional dosage forms such as toothpaste, toothpaste, dentifrice ointment, and water dentifrice. In addition, other ingredients may be those normally used in dentifrice compositions, such as sodium carboxymethyl cellulose, carrageenan, sodium alginate, bentonite, etc. as a binder.
As a wetting agent, such as silicic anhydride, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol as an abrasive, dibasic calcium phosphate (dihydrate, anhydride), calcium carbonate, silicate, insoluble sodium metaphosphate , aluminum hydroxide,
Calcium pyrophosphate etc. are used. In addition, various medicinal agents may be added to the dentifrice composition of the present invention, and such medicinal agents include aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, salt, tranexamic acid, ε-
Examples include aminocaproic acid. According to the present invention, as described above, it is possible to obtain a dentifrice composition that contains a foaming agent with higher safety, has extremely good foaming properties, and does not change the taste of food after use. Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto. Example 1 A toothpaste was prepared in a conventional manner according to the following formulation. Ingredients % Calcium carbonate 40.00 Carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 33.90 Sodium N-long chain acyl glutamate (manufactured by Ajinomoto Co., Ltd., Amisoft HS-11, Acyl group: Hardened beef tallow with 14 to 18 carbon atoms) Fatty acid residue) 2.00 Bactericide, preservative 0.10 Sodium lauroyl sarcosine 0.50 Flavoring agent 1.00 Example 2 A toothpaste was prepared according to the conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 45.00 Carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 30.05 Sodium N-long chain acylglutamate (manufactured by Ajinomoto Co., Inc., Amisoft HS-11) 2.00 Satucalin sodium 0.10 Bactericide, preservative 0.10 N-lauroyl-N-methyl-β-alanine sodium 0.75 Fragrance 1.00 Using the toothpaste composition of Example 1, the "orange youth effect" (after using toothpaste, acidic foods,
A typical example of this was the phenomenon in which the taste of orange juice appears to change significantly (see Special Publication No. 47-43830). The test was conducted by a dedicated panel of five people using a composition (reference example) in which sodium N-long chain acylglutamate and lauroyl sarcocinnarium were replaced with sodium lauryl sulfate (2%) in the composition of Example 1 as a control. The flavor of orange juice taken after using toothpaste was evaluated as follows. 0: No change in flavor, 1: Almost no change in flavor, 2: Slight change in flavor, 3: Significant change in flavor, 4: Significant change in flavor. The results are shown in Table 2 below.

[Table] As is clear from Table 2, the dentifrice composition of the present invention hardly changes the flavor of food after use.

Claims (1)

[Claims] 1 As a blowing agent, 0.5 to 3% by weight of N-long chain acyl sodium glutamate whose acyl group is a hardened tallow fatty acid residue (14 to 18 carbon atoms) and 0.5% by weight or less of sodium lauroyl sarcosine or N-lauroyl-N-methyl. -β-alanine sodium
A toothpaste composition characterized by containing 0.75% by weight or less.