JPS5917084B2 - toothpaste composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a toothbrushing composition, more specifically, a toothbrushing composition that improves foaming properties when using a safer nonionic surfactant as a foaming agent, and changes the taste of food after toothbrushing. The present invention relates to a dentifrice composition that exhibits a never-ending and excellent caries-preventing effect.

Conventionally, anionic surfactants such as sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate, and sodium coconut monoglyceride sulfate have been used as foaming agents in dentifrice compositions.

Among these, sodium alkyl sulfates are commonly used, but they have the major disadvantage of changing the taste of food after use, which is thought to occur when they are absorbed by the taste buds of the tongue and oral mucosa. There are problems such as slight irritation of the oral mucosa and inactivation of enzymes that are added as medicinal agents to toothpaste.

In addition, α-olefin sulfonate and acyl sarcosine sodium taste good on their own and are said to have little effect on the taste of food after brushing, but α-olefin sulfonate has safety issues, and acyl sarcosine sodium Sodium is stable in that it is decomposed in the living body to turn into fatty acids and amino acids, but if the amount is too high, oral mucosal peeling will occur, and if it is too little, there will be insufficient foaming.

Under these circumstances, it has been proposed to use nonionic surfactants as foaming agents from the viewpoint of incorporating highly safe surfactants into dentifrice compositions.

Among the nonionic surfactants, sucrose higher fatty acid ester (hereinafter simply referred to as sucrose fatty acid ester), polyoxyethylene stearyl alcohol ether with an average number of added moles of ethylene oxide of 40, and polyoxyethylene stearyl alcohol ether with an average number of added moles of ethylene oxide of 40 Ethylene monostearate, polyoxyethylene sorbitan monostearate with an average number of added moles of ethylene oxide of 20, polyoxyethylene hydrogenated castor oil derivative with an average number of added moles of ethylene oxide of 60, polyoxy with an average number of added moles of ethylene oxide of 10 to 25 Ethylene sucrose higher fatty acid ester (hereinafter simply referred to as polyoxyethylene sucrose fatty acid ester) is an extremely safe product used in food processing and injectable pharmaceutical compositions, and has a good taste. It has excellent performance such as not being deactivated even when coexisting with oxygen, and is extremely preferable from the viewpoint of safety.

However, these nonionic surfactants generally have the major drawback that they hardly foam, resulting in very poor tooth brushing effect and feel.

The present inventors have conducted various studies in order to obtain a dentifrice composition containing the above-mentioned nonionic surfactant and having good foaming properties, and have found that, together with the nonionic surfactant, it does not cause oral mucosal peeling. It was discovered that a dentifrice composition with extremely excellent foaming properties could be obtained by using a certain amount of sodium acylsarcosinate or other N-long chain acylamino acids or their salts in combination with sodium monofluorophosphate, and the patent application has already been filed. (See Japanese Patent Application No. 50-155315, Japanese Patent Application No. 51-129013, Japanese Patent Application No. 51-140413, and Japanese Patent Application No. 52-5136).

Subsequently, as a result of further research, the present inventors found that instead of sodium monofluorophosphate, sodium fluoride, polyphosphate, and ethylenediaminetetraacetic acid (hereinafter referred to as
It was discovered that a dentifrice composition having excellent foaming properties could also be obtained by using one or more compounds selected from EDTA, and the present invention was completed based on this finding.

That is, the present invention uses, as blowing agents, sucrose fatty acid ester, polyoxyethylene stearyl alcohol ether with an average addition mole number of ethylene oxide of 40, polyoxyethylene monostearate ester with an average addition mole number of ethylene oxide 40, and a polyoxyethylene monostearate ester with an average addition mole number of ethylene oxide of 40. Selected from the group consisting of polyoxyethylene sorbitan monostearate having an average number of added moles of 20, polyoxyethylene hydrogenated castor oil derivative having an average number of added moles of ethylene oxide of 60, and polyoxyethylene sucrose fatty acid ester having an average number of added moles of ethylene oxide of 10 to 25. A dentifrice composition containing a nonionic surfactant containing an N-long chain acylamino acid or a salt thereof, and one or more compounds selected from sodium fluoride, polyphosphate, and EDTA. The dentifrice composition of the present invention has excellent foaming properties,
Unlike conventional dentifrice compositions containing sodium alkyl sulfate, this composition does not change the taste of food after brushing the teeth, and by incorporating sodium fluoride, it exhibits excellent caries prevention effects.

Table 1 below shows the results of tests regarding the relationship between the foaming agent to be blended and foaming properties.

In the test, toothpaste containing various foaming agents and compounds used in combination in the composition of Example 1 described later was diluted to 1/1O with water, and the foam height (m) after 1 minute was measured by the Rosmailes method. The amount of foaming was calculated as the foaming amount.

In addition, the feel of volume was evaluated by brushing the teeth as usual with the toothpaste and evaluating the feel as follows.

◎: Sufficient foaming, ○: Foaming, △: Little foaming, ×: Almost no foaming. Acylamino acid salt, sodium fluoride, polyphosphate or EDTA
No improvement in foaming properties was observed even if only 1.

However, addition of both the N-long chain acylamino acid salt and sodium fluoride, polyphosphate or EDTA significantly improves foaming properties.

Note that although there is a slight difference in the amount of foaming depending on the type of nonionic surfactant used, it has almost no effect on the sensory experience.

Therefore, the N-long chain acylamino acid or its salt used in the present invention may have constituent amino acids such as C, alanine,
phenylalanine, leucine, inleucine, methionine, proline, trif') fan, valine, serine, tyrosine, sarcosine, glutamic acid or ε-aminocaproic acid (regardless of optically active or racemic form), in which the acyl group is a carbon 8 to 22 fatty acid residues, such as acyl groups such as caprylic acid, capric acid, lauric acid, myristic acid, valmitic acid, stearic acid, behenic acid, oleic acid, coconut oil aliphatic or synthetic fatty acids, or mixtures thereof or their N-lower alkyl substituted products or salts thereof.

Examples of such N-long chain acylamino acids or salts thereof include N-myristoyl valine, N-myristoylleucine, N-myristoyl valine, N-myristoyl leucine, N-lauroyl-N-methyl-β-alanine sodium, and N-lauroyl sarcosine sodium and N-lauroyl-N-methyl-β-alanine sodium. Myristoyl isoleucine, N-myristoylmethionine 1. N-myristoylphenylalanine,
N-myristoylproline, N-myristoyltryptophan N N /<lumitoylalanine, N-valmitoylvaline N/<lumitoylleucine, N, o
Lumitoylmethionine, N-palmitoylphenylalanine N, <lumitoylproline, N-balmitoyltryptophan, N-oleoylalanine, N-oleoylisoleucine, N-oleoylphenylalanine, N-0-dioleoyltyrosine , N-oleoyl-β
-alanine, N-oleoyltryptophan, N-lyluoylglycine, N-lyluoylalanine, N-lyluoyl-β-alanine, N-1,1lyluoylvaline, N-
Riluoyl leucine, N-liluoyl isoleucine, N
-riluoylmetheonine, N-1,1 luoylphenylalanine, N-0-silyloyltyrosine, N-liluoylproline, N-liluoyltryptophan, N-liluoyl-β-alanine N IJ luoyl-ε-7
Minocaproic acid or a sodium salt thereof may be mentioned.

These N-long chain acylamino acids or salts thereof exhibit oral mucosal exfoliation properties when blended in large amounts, so when using acylsarcosine or its salts, it should be used in an amount of 0.5% or less (by weight, hereinafter the same), and in other cases Add 0.75% or less.

In the present invention, together with the nonionic surfactant, N-long chain acylamino acid or salt thereof, sodium fluoride,
A compound selected from polyphosphate and EDTA is blended.

These compounds may be used alone or in combination.

Sodium fluoride deteriorates the physical properties of the dentifrice composition when added in large amounts, so it should be 0.5% or less, preferably 0.05%.
~0.22% (200-1000 ppm as fluorine)
) Blend.

In addition, examples of polyphosphates include pyrophosphoric acid, tripolyphosphoric acid, tetrametaphosphoric acid, hexametaphosphoric acid, alkali metal salts such as sodium and potassium salts of insoluble metaphosphoric acid, ammonium salts, and the like. 0.5 to 3 because aluminum tubes used as containers for toothpaste compositions are susceptible to corrosion.
Blend within the range of %.

The EDTA used is preferably disodium salt,
If a large amount is blended, the calcium in the dentifrice base will be eluted and the physical properties of the dentifrice composition will be deteriorated, so it should be blended in a range of 0.5 to 3%.

The nonionic surfactant used in the present invention may be one commonly used. As the sucrose fatty acid ester, any commercially available sucrose higher fatty acid ester can be used, such as DK ester F-50, F-70. , F-90
, F-110, F-140 or F-160 (all manufactured by Daiichi Kogyo Seiyaku Co., Ltd., containing fatty acids from hardened beef tallow as the fatty acid component, and each having a monoester content of 30.40.
50.60 or 70%) or DK ester L-1
8 (manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd., sucrose laurate ester).

Examples of polyoxyethylene stearyl alcohol ethers having an average number of added moles of ethylene oxide of 40 include commercially available Noemalex-640 (manufactured by 8 Hon Emulsion Co., Ltd.), and polyoxyethylene stearate esters having an average number of added moles of ethylene oxide of 40, such as , commercially available Niracol MYS-40 (manufactured by Nikko Chemical Co., Ltd.)
Examples include.

As polyoxyethylene sorbitan monostearate having an average number of added moles of ethylene oxide of 20, for example,
Commercially available Tween 60 (manufactured by Atlas), Niracol TS
-10 (manufactured by Nikko Chemical Co., Ltd.), Emmalex ET600
Examples of polyoxyethylene hydrogenated castor oil derivatives having an average number of added moles of ethylene oxide of 60, such as 0 (Nippon Emulsion Co., Ltd. ff), include commercially available Niracol HCO-
60 (manufactured by Nikko Chemical Co., Ltd.), Emarex HC-60 (
As the polyoxyethylene sucrose higher fatty acid ester having an average addition molar ilO of ethylene oxide of ~25, for example, commercially available TOHOES
Examples include TER-HL-15M (manufactured by Toho Chemical Industry Co., Ltd.).

The blending ratio of these nonionic surfactants can be appropriately selected depending on the formulation of the dentifrice composition, and is blended in a range of 0.25 to 10%.

The dentifrice composition of the present invention can be manufactured according to a conventional method, and can be made into a conventional dosage form such as toothpaste, toothpaste, dentifrice ointment, or water dentifrice.

Other dentifrice base components used include those used in ordinary dentifrice compositions (for example, as abrasives, calcium diphosphate (engineered hydrate, anhydride), calcium carbonate, silicate, calcium pyrophosphate, , insoluble sodium metaphosphate, etc. As binders, sodium carboxymethyl cellulose, carrageenan, sodium alginate, bentonite, silicic anhydride, etc. As wetting agents, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol, etc. are used. .

In addition, the dentifrice composition of the present invention may contain various medicinal agents, such as aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, salt,
Examples include tranexamic acid and ε-aminocaproic acid.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Next, a toothpaste was prepared according to the prescription according to a conventional method.

Example 2 A toothpaste was prepared according to a conventional method using the following formulation.

Example 3 A toothpaste was prepared according to a conventional method using the following formulation.

Example 4 A toothpaste was prepared according to a conventional method using the following formulation.

Example 5 A toothpaste was prepared according to a conventional method using the following formulation.

Example 6 A toothpaste was prepared according to a conventional method using the following formulation.

The dentifrice compositions of Examples 1 to 6 were used to investigate the ``orange juice effect'' (a phenomenon in which the taste of a highly acidic food, typically orange juice, is felt to be significantly different after using the dentifrice). No. 43830) was tested.

The test was conducted as a control using a composition (Reference Example 1) in which the nonionic surfactant and sodium lauroyl sarcosine in the composition of Example 1 were replaced with 2% sodium lauryl sulfate. The flavor of orange juice was evaluated according to the following criteria.

0: No change in flavor, 1: Almost no change in flavor, 2: Slight change in flavor, 3: Significant change in flavor, 4: Significant change in flavor.

The results are shown in Table 2 below.

As is clear from Table 2, the dentifrice composition of the present invention hardly changes the taste of food after use.

Claims (1)

[Claims] 1. Sucrose higher fatty acid ester as a blowing agent, polyoxydiethylene stearyl alcohol ether with an average addition mole number of ethylene oxide of 40, polyoxydiethylene stearate ester with an average addition mole number of ethylene oxide 40, and an average addition of ethylene oxide. From the group consisting of polyoxydiethylene sorbitan monostearate having a mole number of 20, polyoxyethylene hydrogenated castor oil derivative having an average added mole number of ethylene oxide of 60, and polyoxyethylene sucrose higher fatty acid ester having an average added mole number of ethylene oxide of 10 to 25. In a dentifrice composition containing 0.25 to 10% by weight of a selected nonionic surfactant, 0.75% by weight or less of an N-long chain acylamino acid or its salt, provided that 0.0% if the constituent amino acid is sarcosine.
．． With up to 5% by weight, the following groups of compounds: up to 0.5% by weight of sodium fluoride, 0.5-3% by weight of polyJ phosphate and 0.5-3% by weight of ethylenediaminetetraacetic acid or its salts. A toothpaste composition characterized by containing one or more compounds selected from.