JPS6143978B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a coated preparation of thiamine or thiamine salts for fish farming and a method for producing the same. Thiamin preparations added to live feed for anchovies, saury, mackerel, sand eel, etc. used for rearing and aquaculture of yellowtail, sea bream, etc., include thiamin or thiamin coated with 1 to 10 times the amount of higher fatty acids or glycerin fatty acid esters. Preparations containing thiamine salts with a particle size of 100 to 1000 microns have been well received. However, in these preparations, for example, even particles of thiamine hydrochloride coated with three times the amount of hydrogenated tallow oil have a particle size of 100μ or less, or have an average particle size of 200μ or less.
Even when μ, when thiamine hydrochloride was coated with a coating agent in an amount less than 1 times that amount, almost no coating effect was observed in any case. As a result of our research into improving this preparation, we found that by adding a small amount of a waxy substance that is solid at room temperature to the above-mentioned coating agent, we were able to improve the water resistance of the coating agent. It has also been discovered that fatty acid ester type or phospholipid type surfactants are extremely effective in increasing the affinity with thiamine salts. The present invention uses thiamine or thiamine salts as a main ingredient of higher fatty acids or glycerin fatty acid esters,
Furthermore, the present invention is a thiamin-coated preparation for fish farming coated with a coating agent containing a fatty acid ester type or phospholipid type surfactant. Thiamine salts include thiamine hydrochloride, nitrate, lauryl sulfate, thiocyanate, cetyl sulfate, 1,5-naphthalene disulfonate,
Examples include 2,6-naphthalene disulfonate and phthaline salt. Examples of higher fatty acids include lauric acid, palmitic acid, stearic acid, and behenic acid, and examples of glycerin fatty acid esters include mono-, di-, and tri-fatty acid esters of glycerin. If desired, a part of it, for example, about 1 to 20%, can be replaced with a waxy substance that is solid at room temperature, such as beeswax, carnauba wax, shellac, or higher alcohol. As the fatty acid ester type surfactant, sucrose fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, etc. are used, and as the phospholipid type surfactant, phosphatide fatty acid ester is used. Examples include zircholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, and mixtures of these commercially available under the name lecithin. As the coating method, all commonly used methods can be applied. Examples include a spraying method, a rolling method, a fluidized bed method, a solvent method, a granulation method such as a microcapsule method, and a coating method, but the spraying method is particularly preferred because it facilitates mass production. The powder of thiamine or thiamine salts preferably has a particle size of about 5 to 100 μm, the content in the preparation is preferably 10 to 80%, and the particle size of the finished preparation is preferably about 50 to 1000 μm. When producing the formulation of the present invention by, for example, a spraying method, first, the higher fatty acid or glycerin fatty acid ester as the main ingredient of the coating agent is heated and melted, and the above-mentioned surfactant is added and mixed. The mixing ratio of main agent and surfactant is 1:0.01~
Approximately 0.2 is preferable. Thiamine or its salts are then added and mixed uniformly. The surfactant may be added after the addition of thiamine or its salts, and the improvement effect is the same. This mixture is then sprayed into a room at 30° C. or below using a spray device to obtain a powder formulation. Experimental example Thiamine nitrate with a particle size of approximately 30μ is suspended in the required amount of melted hardened beef tallow oil, 5% of the total amount of lecithin is added, and then mixed with a homogenizer.
A preparation is obtained by spraying the mixture into a room controlled at 30°C or lower using a rotating disc type sprayer. Different formulations with different thiamin nitrate content and particle size were prepared, each was mixed with minced anchovies at a ratio of 10mg/100g of thiamine, and after being left at 30°C for 1 hour, the remaining amount of thiamine was measured. Then, Table 1 shows the result. From this result, it is known that even if the particle size of the preparation is small or the content of thiamine nitrate is high, it exhibits a good coating effect.

[Table] Example 1 134Kg of hardened beef tallow oil was heated and melted at 75℃, 10Kg of beeswax, 10Kg of carnauba wax and 6Kg of lecithin were added thereto, and after stirring and dissolving for a while, 40Kg of thiamine nitrate with a particle size of about 50μ was added. Add while stirring with a homomixer to make a homogeneous suspension. When this suspension is maintained at 75°C and sprayed into a room at 30°C using a rotating disc sprayer,
A coated thiamine preparation with a particle size of 200-300μ is obtained. Thiamine nitrate content in this formulation is approximately 20%. Example 2 Heat and melt 70 kg of hardened beef tallow oil at 80°C, add 6 kg of beeswax, 7 kg of carnauba wax, and 3 kg of shellac.
After adding 4 kg of lecithin and stirring to dissolve, 110 kg of thiamine nitrate having an average particle size of about 80 μm is added while stirring with a homomixer to form a uniform suspension. When this suspension is maintained at 80°C and sprayed into a room at 30°C using a rotary disk sprayer, a coated thiamine preparation with a particle size of 200 to 500μ is obtained. Thiamine nitrate content in this formulation is approximately 55
%. Example 3 960g stearic acid and stearyl alcohol
Heat and melt 200g at 75℃, add 40g of sorbitan palmitate, stir and dissolve, then
Add 800g of thiamine nitrate with an average particle size of about 40μ and stir with a homomixer to make a homogeneous suspension. This suspension is sprayed using a rotating disc sprayer.
When sprayed into a room at 30°C, a coated thiamine preparation with a particle size of 150-300μ is obtained. Thiamine nitrate content in this formulation is approximately 40%. Example 4 1.16 kg of extremely hardened beef tallow was placed in a kneader.
Heat and melt at 80°C, add 0.04 kg of commercially available sucrose stearate, stir for a while and maintain at the same temperature. Next, 2.80 kg of thiamine nitrate with an average particle size of 100 μ heated to 60°C was added and stirred at 60 rpm.
Distribute well. This operation was continued for 20 minutes to fully wet the surface of thiamine nitrate with hydrogenated oil, and this dispersion was cooled at a cooling rate of 3°C/min with the same stirring speed.The average particle size was 300μ, and the thiamine nitrate content was approximately
70% preparation is obtained. Application example: Young sea bream (average weight approximately 12.1 g) immediately after being caught are
Four plots were set up with approximately 50 fish in each group in four 2 x 1 m cages. After the animals were raised on food for two days without being fed, minced anchovies were fed. The comparison group contained a preparation containing 20% thiamine nitrate coated with hardened beef tallow oil, and the invention groups 1 to 4 contained the preparations of Examples 1 to 4, respectively, so that the formulation contained 1% thiamine nitrate in lactose. After diluting the mixture to 100 g of minced anchovy, the mixture was administered so that the thiamin nitrate content was approximately 5 mg. The control group contained thiamine nitrate approx.
diluted with lactose to make 0.9g, minced
It was mixed and administered to 100g. The feeding amount for each of the above is 100 for days 0 to 5.
g, 150g from 6th to 15th, and 200g from 16th to 21st.
Table 2 shows the results of measuring the rate of increase in body weight on days 0, 10, and 20 after the start of bait casting, as well as the thiamin content (in muscle) immediately after and 20 days after fishing. These results show that the formulation of the present invention has the same effect as known coating formulations even when the amount of coating agent is significantly reduced, and significantly prevents growth delays caused by continuous feeding of anchovies in Thai aquaculture. known to improve.

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Claims (1)

[Scope of Claims] 1. A thiamin-coated preparation for fish farming, in which thiamine or thiamin salts are coated with a coating agent containing a higher fatty acid or a glycerin fatty acid ester as a main ingredient and a fatty acid ester type or phospholipid type surfactant. 2. A thiamine-coated preparation for fish farming in which thiamine or thiamin salts are coated with a coating agent containing a higher fatty acid or a glycerin fatty acid ester and a waxy substance that is solid at room temperature as the main ingredients, and a fatty acid ester-type or phospholipid-type surfactant. . 3. A method for producing a thiamine-coated preparation for fish farming, characterized by coating thiamine or thiamine salts with a coating agent containing a higher fatty acid or a glycerin fatty acid ester as a main ingredient and further containing a fatty acid ester type or phospholipid type surfactant. .