JPS6217563B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a dentifrice composition, and more particularly to a dentifrice composition with good foaming properties that prevents changes in the taste of food after tooth brushing caused by foaming agents. Conventionally, various anionic surfactants have been used as foaming agents for dentifrice compositions. In particular, sodium alkyl sulfate has excellent foaming properties and is a commonly used foaming agent. However, sodium alkyl sulfates change the taste of food after use, which is thought to occur when they are absorbed by the taste buds of the tongue and oral mucosa, and they also inactivate enzymes that are added as medicinal agents to toothpaste. It has the following disadvantages. Normally, sodium alkyl sulfate is added to the dentifrice composition in an amount of about 1.5% (by weight, the same applies hereinafter), but if the amount is lowered to eliminate the disadvantages of sodium alkyl sulfate, On the other hand, these drawbacks can be overcome by a blending ratio of about 0.1% or less. However, the resulting toothpaste exhibits almost no foaming properties, which significantly reduces its commercial value. The inventors of the present invention have conducted intensive research in order to solve the drawbacks of the formulation of sodium alkyl sulfate in toothpaste and obtain a toothpaste composition with excellent foaming properties. By using a surfactant in combination with sodium alkyl sulfate in a specific ratio, approximately 0.1
% or less, which does not change the taste of food or inactivate enzymes, a toothpaste composition with excellent effervescence can be obtained, without these drawbacks. The present inventors have discovered that the amount of sodium alkyl sulfate can be increased, and have completed the present invention. That is, the present invention uses sucrose ester, polyoxyethylene stearyl alcohol ether (the average number of added moles of ethylene oxide) as a blowing agent.
40), polyoxyethylene monostearate (average number of added moles of ethylene oxide 40),
Polyoxyethylene sorbitan monostearate (average number of added moles of ethylene oxide 20), polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide 60), and polyoxyethylene sucrose fatty acid ester (average number of added moles of ethylene oxide 10~ The present invention provides a dentifrice composition comprising a nonionic surfactant selected from the group consisting of 25), sodium alkyl sulfate, and an N-long chain acylamino acid or a salt thereof in a specific ratio. Although the nonionic surfactant and the N-long chain acylamino acid or its salt used do not change the taste of the food, neither of them has good foaming properties. On the other hand, as mentioned above, sodium alkyl sulfate also has poor foaming properties at low doses without any drawbacks. However, surprisingly, when these surfactants are used in combination, even if the amount of sodium alkyl sulfate is reduced, the foaming properties are excellent, the taste of food does not change, and enzymes that are used as medicinal agents can be produced. A dentifrice composition with extremely excellent performance that does not inactivate the dentifrices can be obtained, and furthermore, even if the amount of sodium alkyl sulfate is about 0.1% or more, the disadvantages can be suppressed. Table 1 below shows the results of tests regarding the relationship between the foaming agent added, foaming properties, and changes in the taste of food after use. The test was conducted according to the method shown below using a sample toothpaste prepared according to the recipe shown below. Toothpaste formulation Ingredients % Dicalcium phosphate dihydrate 45.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Sodium N-lauroylsarcosinate 0.50 Sucrose fatty acid ester Table 1 Displayed amount Sodium lauryl sulfate Table 1 Displayed amount Flavor 1.00 Satucalin Sodium 0.20 Bactericide and preservative 0.10 Water Adjusted to 100% (1) Foaming property: Dilute the sample toothpaste to 1/10 with water and measure the foam height (cm) after 1 minute using the Rosmailes method. compared. (2) Change in the taste of food after use: Orange juice effect (a phenomenon in which the taste of food tastes significantly different when drinking highly acidic food, typically orange juice, after using toothpaste; see Japanese Patent Publication No. 47-43830) ) was tested. (3) Toothpaste properties: The properties of toothpaste were visually observed. In Table 1, the results are shown as follows. ○: No problems in any of the test items (1) to (3) above. Δ: Slightly poor in any one of the test items (1) to (3) above (items shown above the right shoulder). ×: Among the test items (1) to (3) above, any one (item shown above the right shoulder) was significantly poor.

[Table] Also shown in the attached Figure 1 is a graph showing the relationship between the foaming agent added and the change in taste of food after use. The graph in Figure 1 shows the results of the orange youth effect in Table 1. The vertical axis represents the amount of sucrose fatty acid ester (%), and the horizontal axis represents the amount (%) of sodium lauryl sulfate. The hatched areas in the middle indicate areas that do not change the taste of food after toothpaste use, and the cross-hatched areas represent areas that do not change the taste of foods and have good foaming properties. Table 2 below shows the results for toothpaste samples prepared as in Table 1 using various nonionic surfactants and N-long chain acylamino acid salts.
Similar to the table, the results of tests regarding effervescence and changes in the taste of food after use are shown. In Table 2, each nonionic surfactant means the following. A: Sucrose fatty acid ester B: Polyoxyethylene stearyl alcohol ether (average number of added moles of ethylene oxide
40) C: Polyoxyethylene monostearate (average number of added moles of ethylene oxide 40) D: Polyoxyethylene sorbitan monostearate (average number of added moles of ethylene oxide 20) E: Polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide) Average number of added moles: 60) F: Polyoxyethylene sucrose fatty acid ester (average number of added moles of ethylene oxide: 10 to 25)

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[Table] As shown in the results in Tables 1 and 2, by reducing the amount of sodium alkyl sulfate to 0.1% or less, the disadvantage of changing the taste of food after use can be removed, but the foaming property It becomes extremely bad (see Table 2, Test Nos. 73-78). On the other hand, nonionic surfactants and N-long chain acylamino acid salts are satisfactory in terms of changes in the taste of food after use, but each alone or in combination has extremely poor foaming properties. (Table 2, Test No. 1-4, 10, 53, 54, 57, 58, 61, 62,
65, 66, 69, 70, etc.). However, sodium alkyl sulfates, nonionic surfactants and N-
When long-chain acylamino acid salts are blended at a certain ratio, the toothpaste has excellent foaming properties even when the amount of sodium alkyl sulfate is around 0.1%, and also satisfies the change in taste of food after use. is obtained. Moreover, it contains 0.1% sodium alkyl sulfate.
It is also possible to combine the above (Table 2, test
(See Nos. 27, 28, etc.) Thus, in the present invention, 0.4 to 5.0% of a nonionic surfactant to the dentifrice composition and 0.02 to 0.2 part of sodium alkyl sulfate to 1 part (by weight, same hereinafter) of the nonionic surfactant. ,
0.75% or less (for N-long chain acyl sarcosine
0.5% or less) of an N-long chain acylamino acid or its salt. The nonionic surfactant used may be any commonly used sucrose fatty acid ester, and the sucrose fatty acid ester is not limited by the number of carbon atoms or degree of esterification of the fatty acid residue; for example, commercially available
DK Ester F-50, F-70, F-90, F-110,
F-140 or F-160 (both manufactured by Daiichi Kogyo Seiyaku Co., Ltd., contain fatty acids from hardened beef tallow as fatty acid components, and the monoester content is 30, 40, 50,
(60 or 70%) or DK ester L-18 (manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd., sucrose lauric acid ester). Examples of polyoxyethylene stearyl alcohol ether (average number of added moles of ethylene oxide: 40) include commercially available Emarex-640 (manufactured by Nippon Emulsion Co., Ltd.); polyoxyethylene stearate ester (average number of added moles of ethylene oxide: 40); For example, commercially available Nikkor MYS-40 (manufactured by Nikko Chemical Co., Ltd.) may be mentioned. In addition, as polyoxyethylene sorbitan monostearate (average number of added moles of ethylene oxide 20), for example, commercially available Tween 60 (manufactured by Atlas Corporation), Nitsukol TS
-10 (manufactured by Nikko Chemical Co., Ltd.), Emalex ET6000
Examples of polyoxyethylene hydrogenated castor oil derivatives (average number of added moles of ethylene oxide: 60) include commercially available Nikkor HCO-60 (manufactured by Nikko Chemical Co., Ltd.) and Emalex HC-60 (manufactured by Nippon Emulsion Co., Ltd.). Polyoxyethylene sucrose fatty acid esters (average number of added moles of ethylene oxide 10 to 25) include
For example, commercially available TOHOESTER-HL-15M (manufactured by Toho Chemical Industry Co., Ltd.) may be used. In addition, the sodium alkyl sulfate may be any commonly used sodium alkyl sulfate, such as sodium lauryl sulfate, sodium myristyl sulfate, etc., and is usually 0.1 to 0.1 to 100% of the dentifrice composition, depending on the blending ratio with respect to the nonionic surfactant. 1.0%
It is preferable to mix it within the following range. The N-long chain acylamino acid or its salt to be used is such that its constituent amino acids are, for example, alanine, phenylalanine, leucine, isoleucine, methionine, proline, tryptophan, valine, serine, tyrosine, sarcosine, glutamic acid, or ε-aminocaproic acid. (regardless of optically active form or racemic form), fatty acid residues in which the acyl group has 8 to 22 carbon atoms, such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid. , oleic acid, coconut oil fatty acid or synthetic fatty acid, or a mixture thereof, or an N-lower alkyl substituted product thereof, or a salt thereof. Examples of these N-long chain acylamino acids or salts thereof include N-myristoylvaline, N-myristoylvaline, in addition to the above-mentioned sodium N-lauroylsarcosine and sodium N-lauroyl-N-methyl-β-alanine.
N-myristoylleucine, N-myristoylisoleucine, N-myristoylmethionine, N-
myristoylphenylalanine, N-myristoylproline, N-myristoyltryptophan,
N-palmitoylalanine, N-palmitoylvaline, N-palmitoylleucine, N-palmitoylmethionine, N-palmitoylphenylalanine, N-palmitoylproline, N-palmitoyltryptophan, N-oleoylalanine,
N-oleoylisoleucine, N-oleoylphenylalanine, N-O-dioleoyltyrosine, N-oleoyl-β-alanine, N-oleoyltryptophan, N-linoleoylglycine, N-lino Leoylalanine, N-linoleoyl-β-alanine, N-linoleoylvaline, N
-linoleoylleucine, N-linoleoylisoleucine, N-linoleoylmethionine, N-linoleoylphenylalanine, N-O-dilinoleoyltyrosine, N-linoleoylproline, N
-Linoleoyltryptophan, N-linoleoyl-β-alanine, N-linoleoyl-ε-aminocaproic acid, or their sodium salts. These N-long chain acylamino acids or salts thereof exhibit oral mucosal exfoliating properties when blended in large amounts, so in the case of acylsarcosine or its salts, they may be added to the toothpaste composition according to the blending ratio to the nonionic surfactant. It is blended in a range of 0.5% or less, especially 0.3 to 0.5%, and 0.75% or less for others, especially 0.3 to 0.75%. The dentifrice composition of the present invention can be manufactured according to a conventional method,
It can be in the usual dosage forms such as toothpaste, toothpaste, toothpaste ointment, and water toothpaste. Other dentifrice base components used may be those used in ordinary dentifrice compositions, such as dicalcium phosphate (dihydrate, anhydride), calcium carbonate,
Silicates, calcium pyrophosphate, insoluble sodium metaphosphate, etc., as binders, sodium carboxymethylcellulose, carrageenan, sodium alginate, bentonite, silicic anhydride, etc., as wetting agents, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate , polyethylene glycol, etc. are used. Furthermore, the dentifrice composition of the present invention may contain various medicinal agents, such as water-soluble fluorides such as sodium fluoride, tin fluoride, sodium monofluorophosphate, and aluminum. Examples include allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, salt, tranexamic acid, and ε-aminocaproic acid. Next, the present invention will be explained in more detail with reference to Examples. Example 1 A toothpaste was prepared according to a conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 45.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 29.34 Sucrose fatty acid ester 2.00 Sodium N-lauroylsarcosinate 0.50 Sodium lauryl sulfate 0.10 Flavor 1.00 Sodium saccharin 0.20 Sterilization Agents and preservatives 0.10 Sodium monofluorophosphate 0.76 Example 2 A toothpaste was prepared according to the following recipe according to a conventional method. Ingredients % Dibasic calcium phosphate dihydrate 45.00 Sodium carboxymethylcellulose 0.50 Carginan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 30.00 Polyoxyethylene monostearate (average number of added moles of ethylene oxide 40) 2.00 Sodium N-lauroyl sarcosine 0.50 Sodium lauryl sulfate 0.20 Fragrance Ingredients 1.00 Satucharin sodium 0.20 Bactericides and preservatives 0.10 Example 3 A toothpaste was prepared according to the following recipe according to a conventional method. Ingredients % Calcium carbonate 40.00 Sodium carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 32.44 Polyoxyethylene sucrose fatty acid ester (average number of added moles of ethylene oxide 10-25) 2.00 N-lauroyl-N-methyl-β - Sodium alanine 0.75 Flavor 1.00 Sodium saccharin 0.20 Bactericides and preservatives 0.10 Sodium monofluorophosphate 0.76 Example 4 A toothpaste was prepared according to the following recipe in a conventional manner. Ingredients % Calcium carbonate 40.00 Sodium carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 33.40 Polyoxyethylene stearyl alcohol ether (average number of added moles of ethylene oxide 40) 2.00 Sodium N-lauroyl sarcosinate 0.50 Sodium lauryl sulfate 0.30 fragrance 1.00 Satucharin Sodium 0.20 Bactericidal and Preservative 0.10 Example 5 A toothpaste was prepared according to a conventional method using the following formulation. Ingredients % Dibasic calcium phosphate dihydrate 45.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 30.10 Polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide
60) 2.00 Sodium N-lauroyl sarcosine 0.50 Sodium myristyl sulfate 0.10 Flavoring agent 1.00 Sodium saccharin 0.20 Bactericide and preservative 0.10 Example 6 A toothpaste was prepared according to a conventional method using the following formulation. Ingredients % Calcium carbonate 40.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 33.35 Polyoxyethylene sorbitan monostearate (average number of added moles of ethylene oxide 20) 2.00 N-lauroyl-N-methyl-β-alanine Sodium 0.75 Sodium lauryl sulfate 0.10 Flavor 1.00 Satucharin sodium 0.20 Bactericides and preservatives 0.10 The dentifrice composition of Example 1 was tested for orange youth effect. As a control, the test used a composition (Reference Example 1) in which the foaming agent in the composition of Example 1 was changed to 1.5% sodium lauryl sulfate, and a panel of 10 experts examined the flavor of orange juice drunk after using toothpaste. Evaluation was made according to the criteria. 0: No change in flavor, 1: Almost no change in flavor,
2: Flavor changes slightly; 3: Flavor changes considerably; 4: Flavor changes significantly. The results are shown in Table 3 below.

[Table] As is clear from Table 3, the dentifrice composition of the present invention hardly changes the taste of food after use.

[Brief explanation of the drawing]

FIG. 1 is a graph showing the relationship between the foaming agent added and the change in taste of food after use.

Claims (1)

[Claims] 1. Average number of moles added of sucrose ester and ethylene oxide in an amount of 0.4 to 5.0% by weight based on the total amount of the composition.
Polyoxyethylene stearyl alcohol ether with 40, polyoxyethylene monostearate with an average number of added moles of ethylene oxide of 40,
From polyoxyethylene sorbitan monostearate with an average number of added moles of ethylene oxide of 20, polyoxyethylene hydrogenated castor oil derivative with an average number of added moles of ethylene oxide of 60, and polyoxyethylene sucrose fatty acid ester with an average number of added moles of ethylene oxide of 10 to 25. A nonionic surfactant selected from the group consisting of a nonionic surfactant, sodium alkyl sulfate in a proportion of 0.02 to 0.2 parts by weight per 1 part by weight of the nonionic surfactant, and an N-long chain acylamino acid or a salt thereof, In addition, the amount of N-long chain acylamino acid or its salt in the entire composition is 0.3 to 0.75% by weight when the constituent amino acid is other than sarcosine, and 0.3 to 0.5% by weight when the constituent amino acid is sarcosine. Characteristic toothpaste compositions. 2. The dentifrice composition of item 1 above, wherein the sodium alkyl sulfate is sodium lauryl sulfate. 3. The dentifrice composition of item 1 above, wherein the sodium alkyl sulfate is sodium myristyl sulfate. 4. The dentifrice composition according to any one of Items 1 to 3 above, which contains 0.1 to 1.0% by weight of sodium alkyl sulfate.