JPS6222719B2 - - Google Patents

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention is directed to a rotary tablet machine for producing a tablet of pharmaceuticals, etc. by compression molding a powder so as to cover a core tablet. An automatic core lock supply position that detects the presence and position of the core lock previously supplied or placed in the mortar hole and automatically corrects the position of the core lock placed in the mortar hole by the core lock supply device. It concerns an adjustment device.

(Prior art) Generally, in order to manufacture dry-coated tablets used for pharmaceuticals, etc., a first powder is placed in a large number of dies arranged on a rotary disk, and then a core tablet is placed on top of the powder. The core tablet is placed on the core tablet by a feeding device, and then the second powder is filled from above, and then compressed with an upper punch and a lower punch to obtain a core tablet as a molded product.

Conventionally, it has been impossible to detect the position in the mortar at which the core tablet is fed, and even non-core tablets to which the core tablet is not fed, during the operation of the tablet machine. After taking out the product, the dry-coated tablet, from the tablet machine, either conduct a destructive inspection of the dry-coated tablet to confirm the position of the cored tablet, or check all the tablets to determine whether there are any non-coated tablets, based on weight differences, etc. Even when the tablet machine is operating, the position of the core tablet placed in the die is detected by the feeding device, and this detection prevents the placement position of the core tablet from being deviated beyond a predetermined value. Nothing has been developed that allows the position of the core lock placed by the feeding device to be automatically corrected if the user is concerned.

(Problems to be Solved by the Invention) In a dry-coated tablet used for medicine, etc., the core tablet and the surrounding tablet portion, i.e., the outer covering portion, are made of different types of drugs, and when the tablet is taken, It acts in two or more places, but if there is no core tablet, that is, if it is a non-core tablet, or if the core tablet is not located in the center of the outer shell and is eccentric, then when taken. There are important problems with the properties of dry-coated tablets, such as not working properly, changes in action over time, and easily cracking due to impact during the manufacturing process.

In a rotary dry-coated tablet machine that produces such dry-coated tablets, the core tablet must be fed into the mortar of a rotary disk that rotates at high speed. The core tablets are held in advance in a disk having a hole, and the core tablets are dropped one by one from above the mortar.

However, if the rotary core tablet machine stops, the core tablet will fly out of the hole in the disc due to inertia, and this is because a detector etc. can be used to confirm that the core tablet is held in the hole in the disc in advance. This may occur even after the tablet has been processed, and there is a risk that the tablet may be treated as a normal tablet even though the tablet has not actually been fed into the mortar.

In addition, due to scratches on the core tablet, surface condition (such as when the surface is coated with a film, etc.), or changes in the powder properties (such as fine powder or granules), the timing of supply of the core tablet may be disrupted, or the core tablet may not be supplied onto the powder. The feeding position may be deviated due to slipping or submergence of the core lock, so even if the core lock is adjusted to be located at the center of the powder in the mortar hole at the start of work, the core lock may become erroneous during operation. The tablet is no longer centered in its core.

In recent years, rotary core tablet machines of this kind have tended to become faster and faster, and the types of core tablets such as properties and sizes have also tended to become more diverse. It is possible to detect the placement position and remove non-core tablets or core tablets whose core tablets are eccentric by more than a set value, and if the core tablet is eccentric by a predetermined value or more, the core tablet feeding device will There was an important problem in manufacturing control of dry-coated tablets in that the position of the cored tablets to be placed had to be corrected.

(Means for Solving the Problems) In order to solve such problems, the configuration of the present invention is such that a first mortar hole is provided in the mortar hole of the mortar 2 disposed on the rotary disk 1.
The core tablet 7 held in advance by the core tablet supply device 6 is placed on top of the powder 5a, and the core tablet 7 is placed on top of the powder 5a.
After filling the second powder 5b so as to cover the upper punch 1
7 and a lower punch 3 to produce an organic tablet 11, the first powder 5a
After placing the core tablet 7 on top and before filling the second powder 5b, the inside of the mortar hole of the mortar 2 is irradiated, and the powder 5a and the core tablet 7 in the mortar hole of one mortar 2 are irradiated. Multi-optical axis color-coded sensor 2 that detects the position of the core lock 7 placed in the mortar hole by detecting color differences at multiple locations
0, the core lock supply device 6 is configured to be movable, and the core tablet supply device 6 and the color-coded sensor 20 are linked, so that the color-coded sensor 20 is arranged at a position where the core lock 7 is placed. When it is determined that the powder is eccentric, the position of the core lock 7 placed on the powder 5a in the mortar hole is automatically corrected by the core lock supply device 6 in response to the detection signal. This is an automatic core tablet supply position adjustment device for a rotary core tablet machine.

In the above configuration, when the color-coded sensor 20 determines that the placement position of the core tablet 7 is eccentric for a predetermined number of times, the core tablet feeding device 6 places the core tablet 7 on top of the powder 5a in the mortar hole. The position of the core lock 7 can be automatically corrected.

In this case, it is not necessary to correct each case where the placement position of the core lock 7 is suddenly eccentric, so that excessive correction can be prevented and the correction accuracy can be further improved.

Further, in the above configuration, the color-specific sensor 20 is
If no color difference is detected or if the eccentricity of the core lock 7 exceeds a set value, it can be rejected as a defective product.

In this case, defective non-coated tablets and eccentric organic tablets will not be mixed with good dry-coated tablets.

Furthermore, in the above configuration, the color-specific sensor 20 is
The detected position of the core lock 7, that is, the degree of eccentricity and presence or absence, can be displayed or recorded.

In this case, quality control in the manufacturing process of the tablet machine can be easily performed.

(effect) The above technical means works as follows.

The core tablet 7 of the mortar 2 containing the first powder 5a is fed, i.e. placed on said powder 5a, and then the second powder 5a is loaded.
The turntable 1 rotates to supply b,
At a position before the second powder 5b is supplied, the color difference between the powder 5a and the core tablet 7 is detected by a multi-optical axis color sensor 20 that illuminates the inside of the mortar hole of the mortar 2 at a plurality of locations. For example, as shown in FIG.
If the respective optical axes of the O direction sensor C and the S direction sensor D have a predetermined color difference between the powder 5a and the core tablet 7, it is recognized as normal. If the lock 7 is eccentric in the direction of the arrow R or the direction of the arrow S, the sensors A and B respectively
Or, the color difference detected by sensors C and D changes, that is, the core lock 7 in FIG. 4 is eccentric in the direction of arrow R, and the core lock 7
If the color is darker than powder 5a,
The R direction sensor A receives a low light intensity and emits a (-) signal, and the opposite L direction sensor B receives a high light intensity and emits a (+) signal. RL direction and arrow SO
The core lock supply device 6 is formed to be movable in the direction,
It is corrected by moving in the L direction by a distance corresponding to the value of that signal.

If each of the above sensors A, B, C, D
If none of them detects a color difference between the powder 5a and the core tablet 7, it is recognized and memorized as a non-core tablet, and if the core tablet 7 is judged to be eccentric by more than a set value, it is also recognized and memorized, and it is determined that it is a good product. It is to be discharged as a defective product separately from certain dry-coated tablets.

Regarding correction when it is determined that the core lock 7 is eccentric, for example, 10
It is preferable to correct the eccentricity when it is determined that the eccentricity has occurred continuously in the same direction. Also, if the eccentricity is repeated intermittently in one direction, it is preferable to correct the eccentricity by about half of the value. It is something.

Note that the color-coded sensor 20 is synchronized with the rotating mortar 2, and the color-coded sensor 20 is synchronized with the rotating mortar 2.
Even if the powders put into the mortar 2 are of the same color, the powder compressed into the core tablet 7 will be a little darker in color, so the color difference can be instantly detected.

(Embodiment) An embodiment of the present invention will be described with reference to the drawings. Reference numeral 1 is a rotary disk on which a large number of dies 2 are arranged at equal intervals on the circumference.

6 is a core lock supply device synchronized with the rotary disk 1 for dropping and supplying the core lock 7 into the hole of the mortar 2;
The core lock supply device 6 holds the core lock 7 sent from the feeder 12 through the feeding pipe 13 in advance in the hole of the disc, and detects that the core lock 7 is held. It is detected by the lock detection phototube 16, and if the core lock 7 is not held, the signal from the timing phototube 15 and the timing hole 14 is memorized, so that the position of the mortar 2 that becomes the coreless lock is determined. is memorized, and the coreless tablet is taken out to the coreless tablet chute 23 by the removal damper 18.

Further, this core tablet supply device 6 meshes with a drive gear (not shown) that is provided below the rotary disk 1 and rotates together with it, and a first shaft 3 that is fixed to a tablet machine or the like.
6, a first gear 31 is rotatably attached to the first gear 31; A second gear 32 rotatably attached to two shafts 37
and a disc shaft 38 which meshes with the second gear 32 and is rotatably attached to a bearing attached to a second connecting plate 35 which is swingably disposed on the first shaft 36.
The disc gear 33 attached to the disc gear 33 is synchronized with the rotary disc 1, and the disc shaft 38 is disposed on an extension of the straight line connecting the first shaft 36 and the second shaft 37.
Universal joint on the first connecting plate 34, PL adjustment shaft 2
A PL adjustment motor 27 is attached via the second
An OS adjustment motor 28 is attached to the connecting plate 35 via a universal joint and an OS adjusting shaft 30, and when the PL adjusting shaft 29 is expanded and contracted by rotating the PL adjusting motor 27 of the first connecting plate 34, the first connecting plate 34 is moved. The two shafts 37 swing around the first shaft 36, thereby providing a second shaft rotatably attached to the second shaft 37.
A disc gear 33 attached to a gear 32 and a disc shaft 38
The engagement changes around the disc axis 38, and the supply of the core lock 7 held by the disc to the mortar hole of the mortar 2 is adjusted in the direction of the arrow RL, which is the circumferential direction of the disc. It is possible.

Also, the second connecting plate 35 is connected to the OS adjustment motor 2.
When the OS adjustment shaft 30 is expanded or contracted by rotation of 8, the disc shaft 38 swings around the first shaft 36, and the meshing of the second gear 32 and the disc gear 33 occurs in the direction of the center of the rotary disc 1. It can be adjusted in the direction of a certain arrow SO.

Note that each of the above adjustments requires only a small adjustment range because the hole diameter of the die 2 is relatively small, and the first gear 31, the second gear 32, and the disc gear 33 are arranged almost in a straight line. Since the adjustment operation can be performed independently of each rotating gear, etc., it can be arbitrarily adjusted even while the tablet machine is in operation.

5a is the first powder put into the hole of the mortar 2, and the powder 5a falls from the powder outlet 19,
A fixed amount is fed into the mortar 2 by the first feed system 4.

5b is a second powder that is filled by the second feeder 8 after the first powder 5a enters the hole of the mortar 2, and then the core tablet 7 is supplied.

3 is the lower pestle, 17 is the upper pestle, 9 is the lower pestle 3 and the upper pestle 17
This is a compression roll for compressing from above and below.

11 is a molded dry-coated tablet that has a normal core tablet 7 and is determined to be normal by the color-coded sensor 20 described below. It is taken out and the receiving can 2
Fall into 2.

20 is a multi-optical axis color-coded sensor disposed at a position after the core tablet 7 is supplied until the second powder 5a is filled, and the color-coded sensor 20 is arranged in the R direction of the arrow. A fiber section 20c that emits four signals from the S direction sensor D as sensor A, L direction sensor B, and O direction sensor C, and detection that transmits and receives color-coded signals to the respective sensors A, B, C, and D. It consists of a control section 20b, a control section 20a that amplifies and controls the respective signals, and a stabilized power supply 20d.

Reference numeral 25 denotes a storage device for storing defective or good products such as non-nucleated tablets or eccentric cored tablets of the nuclear tablet 7 detected and recognized by the color-coded sensor 20; Of course, it displays and records the degree to which the core lock 7 is eccentric, etc., and if it is memorized as defective as described above,
Thereafter, the solenoid 24 is operated and the removal damper 18 removes the lock into the non-nuclear lock chute 23.

Reference numeral 26 denotes a drive control unit for driving the PL adjustment motor 27 or the OS adjustment motor 28 in response to a signal indicating that the core lock 7 is eccentric by the color-coded sensor 20. teeth,
The respective motors 27 and 28 may be driven by the number of rotations corresponding to the signal value determined to be eccentric, or the respective motors 27 and 28 may be driven by time control in response to the signal value. may be driven.

The color-coded sensor 20 is normally used for the mortar 2 of the rotary plate 1.
The first powder 5a is put into the hole, and then the core tablet 7 is fed into the mortar 2, which is placed on top of the powder 5a by the core tablet supply device 6, and the respective color-coded signals are sent to the sensor A. , B, C, and D irradiate,
Detecting color differences between the powder 5a and the core tablet 7 at four locations,
If it is recognized that the core lock 7 is being supplied normally as shown in FIG. The products are taken out to the receiving can 22 as good products.

If the core lock 7 is eccentric from the predetermined position as shown in Figures 4 and 5, or if it is a coreless lock,
The color difference of each of the above-mentioned sensors A, B, C, and D changes, and for example, when the core lock 7 is eccentric in the direction of the arrow R as shown in FIG. 4, the sensor A detects more colors of the core lock 7. Therefore, the amount of eccentricity of the core tablet 7 is recognized based on the detected amount of color difference, and if it exceeds the set amount, it is determined to be defective, and if it is determined that the feeding position needs to be corrected, each sensor A ,B,
C and D detect the direction and amount of eccentricity, and in response to the detection signal, the drive control unit 26 rotates the PL adjustment motor 27 or the OS adjustment motor 25 in the direction in which correction is required in the forward or reverse direction. According to
PL adjustment shaft 29 or OS adjustment shaft 30
By changing the length of the core lock supply device 6 and moving the core lock supply device 6, the core lock 7 is automatically supplied to the center of the mortar 2.

The present invention is not limited to the above-mentioned embodiments. For example, a multi-optical axis color sensor can be implemented by having two or more sensors, and if the detection signal is a digital signal, each adjustment can be carried out. The motor is a step motor (pulse motor) that can be digitally controlled.

In addition, the present invention inputs detection signals from color-specific sensors into a microcomputer, etc., controls each device as a storage device and drive control unit, and performs quality control by processing data such as the degree of eccentricity of the core lock. It is something that can be done.

(Effects of the Invention) As explained above, the present invention allows the core lock to be directly fed into the mortar using a multi-optical axis color sensor after the feeding process. It detects the presence and position of the core lock to determine whether it is good or bad, and if it is determined that the core lock feeding position is bad and needs to be corrected, it automatically adjusts the subsequent feeding position to normal. It is possible to completely eliminate not only non-core tablets but also core tablets that are defective due to their eccentricity, and it also automatically feeds core tablets so that they are always located in the center of the mortar. The position can be adjusted and eccentric core tablets, which are defective core tablets, can be minimized.

In addition, as mentioned above, there is no possibility that defective non-nucleated tablets or eccentric cored tablets will mix into good non-nuclear tablets, so there is no need to use other non-nucleated tablet sorting equipment or products. There is no need for destructive testing, etc., and the degree of eccentricity of the core tablet can be sequentially displayed and recorded, so it has the effect of facilitating quality control, which is important due to the nature of core tablets used in pharmaceuticals, etc.

[Brief explanation of the drawing]

The drawings show an automatic adjustment device for a core tablet feeding device of a rotary core tablet machine according to the present invention, and FIG. 1 is a plan view, and FIG. 2 is a view of the inside of the mortar when normal core tablets are manufactured. A cross-sectional view explaining the state etc. of the third
, FIG. 4, and FIG. 5 are enlarged plan views of essential parts for explaining the detection states of the color-specific sensors. In the drawings, 1 is a rotary disk, 2 is a mortar, 3 is a lower punch, 4 is a first feedstock, 5a and 5b are powders, 6 is a core tablet supply device, 7 is a core tablet, 8 is a second feedstock, and 9 is a Compression roll, 10 damper, 1
1 is a dry-coated tablet, 12 is a feeder, 13 is a feeding pipe, 14 is a timing hole, 15 is a timing phototube, 16 is a nuclear tablet detection phototube, 17 is an upper punch, 18 is an exclusion damper, 19 is a powder dropper, 20 20 is a color-specific sensor, 20a is a control unit, 20b is a detection unit, 20
c is a fiber part, 20d is a stabilized power supply, 21 is a chute, 22 is a receiver, 23 is a non-nuclear lock chute,
24 is a solenoid, 25 is a storage device, 26 is a drive control unit, 27 is a PL adjustment motor, 28 is an OS adjustment motor, 29 is a PL adjustment shaft, 30 is an OS adjustment shaft, 31 is a first gear, and 32 is a second gear , 33
34 is a disk gear, 34 is a first connecting plate, 35 is a second connecting plate, 36 is a first shaft, 37 is a second shaft, and 38 is a disk shaft.

Claims (1)

[Claims] 1. A first powder 5a is put into a mortar hole of a mortar 2 disposed on a rotary disk 1, and a core tablet 7 held in advance by a core tablet supply device 6 is placed on top of the powder 5a. In the rotary core tablet machine, the second powder 5b is filled so as to cover the core tablet 7, and then compressed by the upper punch 17 and the lower punch 3 to produce the core tablet 11. After placing the core tablet 7 on top of the powder 5a and before filling the second powder 5b, the inside of the mortar hole of the mortar 2 is irradiated, and the powder 5a and the core tablet in the mortar hole of one mortar 2 are irradiated. A multi-optical axis color-specific sensor 20 is installed to detect the position of the core lock 7 placed in the mortar hole by detecting color differences from the core lock 7 at multiple locations, and the core lock feeding device 6 is movable. The core tablet supply device 6 and the color-coded sensor 20 are connected, and the color-coded sensor 20 is connected to the core tablet 7.
When it is determined that the placement position of the powder 5a is eccentric, the core tablet supply device 6 automatically corrects the position of the core tablet 7 placed on the powder 5a in the mortar hole in response to the detection signal. An automatic core tablet supply position adjustment device for a rotary core tablet machine, characterized in that: 2 If the color-coded sensor 20 determines that the placement position of the core lock 7 is eccentric for a predetermined number of times,
The rotary type rotary machine according to claim 1, characterized in that the position of the core lock 7 placed on the powder 5a in the mortar hole is automatically corrected by the core lock supply device 6. Automatic core tablet feeding position adjustment device for core tablet machine. 3. Claims 1 or 2 are characterized in that when the color sensor 20 does not detect a color difference or when the eccentricity of the core lock 7 exceeds a set value, it is rejected as a defective product. An automatic core tablet supply position adjustment device for a rotary core tablet machine as described in 2.