JPH0796029B2 - Blood sampling device for measuring blood sampling weight - Google Patents

Description

Description: [Industrial field of use] The present invention relates to a blood collecting apparatus for measuring the weight of collected blood.

[Prior Art] Conventionally, a blood collecting device as described in Japanese Patent Publication No. 51-3153 has been proposed. The conventional blood collection device stores a blood bag in the blood collection chamber, detects that the thickness of the blood bag that expands with blood collection reaches a predetermined level with a limit switch, and stops the blood collection operation based on this detection result, As a result, a predetermined amount of blood is collected in the blood bag.

Further, in the conventional blood collection device, the blood bag tray is swung during blood collection into the blood bag, whereby the anticoagulant such as heparin and the like preloaded in the blood bag are stirred. This is to prevent blood coagulation.

[Problems to be Solved by the Invention] However, in the above-described conventional blood collection device, the blood collection amount is measured when the thickness of the blood bag reaches a certain level, and therefore the measurement accuracy is poor.

Therefore, in order to improve the measurement accuracy of the blood collection amount, the present applicant considered to measure the blood collection amount by measuring the weight change of the blood bag during blood collection.

Then, as described above, blood is collected while rocking the blood bag for agitation of the anticoagulant and blood, and in measuring the weight change thereof, in order to stabilize the measurement accuracy of the blood collection amount, It was considered to temporarily stop the rocking and measure the weight of the blood bag while calming the fluctuation of the liquid level in the bag within the rocking stop time.

However, as a result of the experiment, if the rocking stop time for each rocking cycle given to the blood bag is too short, the accuracy of the weight measurement becomes poor, and if the rocking stop time is too long, the anticoagulant and blood There was a problem that solidification was not possible due to insufficient stirring with.

It is an object of the present invention to improve the accuracy of measuring the weight of collected blood and to sufficiently stir the blood to prevent coagulation.

[Means for Solving the Problem] The present invention according to claim 1 provides a container support part for supporting a blood container, a swinging means for rocking the container support part during blood collection into the blood container, and a blood collecting process. And a weight measuring means for measuring the weight of blood collected in the blood container, wherein one swing cycle of the container support part by the swing means at least at an intermediate to an end stage of collecting blood in the blood container. The oscillating operation by the oscillating means is temporarily stopped every time, and the oscillating stop time for each oscillating cycle is made longer at the end stage of blood collection, and the weight measurement is performed within the oscillating stop time. The control means for taking in the measurement result of the means and for obtaining the blood sampling weight or the blood sampling remaining amount in the blood container based on the measurement result is provided.

In the present invention according to claim 2, the rocking stop time is 0 to 0.5 seconds, and the intermediate stage is 50 to 20% in the initial stage when the residual blood sampling amount to the blood container is 100 to 50% of the set blood sampling amount. The rocking stop time is 0.5 to 1 second, and the rocking stop time is about 1 second at the end stage of 20% or less.

According to a third aspect of the present invention, after the blood collection of the designed blood collection amount into the blood container is completed, the rocking operation by the rocking means is extended for a predetermined time.

According to a fourth aspect of the present invention, the stopping operation of the rocking by the rocking means is performed at a turning point in the rocking process.

According to a fifth aspect of the present invention, the blood inlet to the blood container is positioned at the lowest level of the blood container when the rocking by the rocking means is stopped.

[Operation] According to the present invention described in claims 1 and 2, there is the following operation (1).

(1) The rocking stop time for each rocking cycle is made longer at the end stage of blood collection. That is, since the weight measurement accuracy does not have to be so high in the initial stage to the intermediate stage of blood collection, the rocking stop time is set to 0 to a short time so that the anticoagulant and blood are sufficiently stirred. And at the end of blood collection,
In order to improve the accuracy of the weight measurement, the rocking stop time is gradually increased so that the weight can be measured in a state where the blood flow in the container is sufficiently suppressed. As a result, the accuracy of measuring the weight of collected blood can be improved, and the blood can be sufficiently stirred to prevent coagulation.

According to the present invention described in claim 3, there is the following effect (2).

(2) After the blood collection is completed, the anticoagulant and blood can be more sufficiently stirred by rocking the blood container for a certain period of time to prevent coagulation more reliably.

According to the present invention described in claim 4, there is the following effect (3).

(3) The weight of the collected blood is measured when the container support part has the least swinging motion (the turning point above or below the swinging process or in the vicinity thereof), and the shake in the blood in the container is minimized. Accurate weight measurement is possible because the measurement is performed at a certain timing. Further, since the container support is not temporarily stopped in the intermediate process of rocking, the anticoagulant in the container and blood can be well mixed in the rocking process and blood coagulation can be prevented.

According to the present invention described in claim 5, there is the following effect (4).

(4) When the swing is stopped, the blood inlet to the blood container is positioned at the lowest level of the container. This can prevent the air in the blood container from accidentally flowing out from the blood inlet to the donor side.

[Embodiment] FIG. 1 is a front view showing a blood collecting device according to an embodiment of the present invention, FIG. 2 is a side view showing a main portion of FIG.
1 is a plan view of FIG. 1, FIG. 4 is a side view showing a scale, FIG. 5 is a vacuum circuit diagram, FIG. 6 is a rocking state diagram, and FIG. 7 is a control block diagram.

The blood collection device 10 has a housing as shown in FIGS. 1 to 3.
A display panel 12 is provided in front of 11, and a vacuum blood collection chamber 13 is formed inside the housing 11. 14 is the open / close lid of the blood collection room 13,
Reference numeral 15 is a hinge of the lid 14, and 16 is a sealing rubber for sealing the blood collection chamber 13. 14A is a handle of the lid 14. Also, blood collection device 10
Is a vacuum pump 17 and a controller 18 at the bottom of the housing 11.
Built in.

The vacuum blood collection chamber 13 of the blood collection device 10 has an intake port 17 of a vacuum pump 17.
It is provided with a bag tray 19 which is communicated with A so that the pressure can be reduced and which supports a blood bag (blood container) 1 made of polyvinyl chloride or the like. The blood collection device 10 includes a vacuum blood collection chamber 13
Under reduced pressure, blood is collected by applying a predetermined negative pressure to the blood bag 1 supported by the back tray 19. At this time, the blood collecting device 10 shakes the bag pan 19 to stir the anticoagulant such as heparin and the like preloaded in the blood bag 1 and the blood, and measures the weight of the blood bag 1 to collect the blood. Measure the quantity.

The structure for rocking the bag tray 19 in the blood collecting device 10 and the structure for measuring the weight of the blood bag 1 are as follows.

First, a pedestal 20 is installed at a lower portion of the vacuum blood collection chamber 13, and a oscillating frame that is rotatable on the pedestal 20 via a support shaft 21.
22 are supported. Further, a swing motor 23 is fixed to the frame 20, and a driving shaft 24 driven by the swing motor 23 is supported. A crank wheel 28 is fixed to one end of the driving shaft 24, one end of a link 29 is connected on the turning radius of the crank wheel 28, and the other end of the link 29 is connected to the swing frame 22.
Are linked to.

On the other hand, a scale mounting member 31 is fixed to the upper surface of the swing frame 22, and a scale (weight measuring means) 33 is supported on the scale mounting member 31 in a cantilever manner. The scale 33 is composed of a substantially rectangular (parallelogram) frame as shown in FIG. The scale 33 is attached to each of two positions on the upper surface and two positions on the lower surface to form a Wheatstone bridge circuit.
The above-mentioned bag tray 19 is fixed to the tip of the balance 33 via a weighing platform 35 and a receiving plate 36. The scale 33 has a weight sensor amplification unit 38.

That is, the blood collection device 10 operates in accordance with the operation of the swing motor 23 so that the drive shaft 2
4, rotate the crank wheel 28, which causes the swing frame 2
2 is swung, and the bag tray 19 supported by the swing frame 22 via the scale 33 is swung. At this time, as shown in FIGS. 2 and 6, the bag tray 19 is located above and below the highest rising point forming + α degrees and the lowest descending point forming −β degrees with respect to the horizontal.
The point is swung as the turning point of the swing process.
In this example, it was confirmed that α = β = 20 degrees is preferable, as described later. Further, the one cycle time of the rocking that the rocking motor 23 imparts to the bag tray 19 is about 1.0 in the region where the power supply frequency is 60 Hz.
~ 2.6 seconds, about 1.2 ~ 3 seconds in the power supply frequency 50Hz area.
When the one cycle time is too long, the mixing of the anticoagulant in the blood bag 1 and the blood becomes weak, but when it is too short, the blood in the blood bag 1 follows the movement of the bag tray 19. It exhibits a phenomenon that the mixture becomes poorly mixed and becomes difficult to mix.
Further, the blood sampling device 10 supports the bag tray 19 on a scale 33 that is cantilevered on the swing frame 22 via a scale mounting member 31, and outputs the strain gauge 34 based on the flexural deformation of the scale 33. The weight of the blood bag 1 is measured by the change, and the blood collection amount is measured.

The blood sampling device 10 detects the rotational position of the detection cam 39 provided at the other end of the driving shaft 24 by the optical sensor 40, and the control device 18
Recognizes the current swing angle position of the back tray 19 by the swing motor 23, and the above-mentioned bag tray 19 is at the turning point of either the highest point or the lowest point. The measurement result of the scale 33 is taken in and the weight of the blood bag 1 is measured.

At this time, in the control device 18 of the blood collection device 10, the bag tray 19 is turned back at each turn cycle of the bag tray 19 by the swing motor 23 during the initial to final stages of blood collection in the blood bag 1. The swing motor 23
The oscillating motion due to is temporarily stopped, and the oscillating stop time for each oscillating cycle is made longer on the end stage side.

Specifically, the amount of blood remaining in the blood bag 1 is the set amount of blood collected.
In the initial stage of 100 to 50%, the swing stop time is 0 to 0.5.
In the intermediate stage, which is 50 to 20%, the rocking stop time is 0.5 to
At the end stage of 1 second, 20% or less, the swing stop time is about 1
Seconds.

In addition, FIG. 8 (A) is a time-dependent output voltage diagram of the balance at the initial stage of blood collection, and FIG. 8 (B) is a time-dependent output voltage diagram of the scale at a blood collection end stage at a blood collection amount of 200 ml. FIG. 8 (C) is a time-dependent output voltage diagram of the balance at the blood collection end stage when the blood collection amount is 400 ml.

In FIGS. 8A to 8C, the output voltage of the scale is the weight.
Since 800g is set to 4VFS, a voltage of 0.15V corresponds to a weight of about 30g.

In each of FIGS. 8A to 8C, one swing cycle is 1.26 seconds.

Then, in the initial stage of blood collection shown in FIG.
It takes about 0.3 seconds for the output of the scale 33 to stabilize after the 19 stops after one swing cycle. Therefore, as described above, if stopped for 0.5 seconds, the weight can be sufficiently measured, and the anticoagulant and blood can be sufficiently stirred.

Further, at the blood collection end stage at the blood collection amount of 200 ml in FIG. 8B, it takes about 0.3 seconds for the output of the scale 33 to stabilize after the back tray 19 has stopped after one swing cycle. Therefore, as described above, a high weight measurement accuracy can be secured by stopping for approximately 1 second.

Further, at the blood collection end stage of the blood collection amount of 400 ml in FIG. 8C, it takes about 0.4 seconds for the output of the scale 33 to stabilize after the bag tray 19 has stopped after one swing cycle. That is,
When the amount of collected blood is large, the stabilization time becomes long, but as described above, if it is stopped for about 1 second, high accuracy of weight measurement can be secured.

Further, in the blood collecting device 10, the blood bag 1 is swung so as to ensure the blood coagulation is prevented, and the swing space of the back tray 19 is made as small as possible to make the blood collecting device 10 compact. In order to realize the rack, the appropriate swing angle range “[+ α degree] to [−β” of the highest point or the lowest point of the bag tray 19 is realized.
]] Was determined as follows. That is, [+ α degree] that determines the above-mentioned highest point of the bag tray 19 is [+10 degrees to +40 degrees].
Degrees], more preferably [+10 degrees to +30 degrees], and most preferably within an angle range of [+15 degrees to +25 degrees],
In this example, it is set to [+20 degrees]. Also, the bag saucer 19
[-Β degree] that determines the above-mentioned lowest descent point of
40 degrees], more preferably [-10 degrees to -30 degrees], and most preferably within an angle range of [-15 degrees to -25 degrees]. ]

In addition, the swing angle range of the above-mentioned bag tray 19 is "[+ α degree]-
[-Β degree] is experimentally changed to "[+8 degree] to [-8 degree".
Degree] "," [+12 degree] ~ [-12 degree] "," [+15 degree] ~
[−15 degrees] ”,“ [+18 degrees] to [−18 degrees] ”, [+21
Degree] ~ [-21 degree] "," [+24 degree] ~ [-24 degree] ",
"[+30 degrees] ~ [-10 degrees]", "[+25 degrees] ~ [-15"
Degree] "," [+25 degree] ~ [-5 degree] "," [+20 degree] ~
Blood bag 1
As a result of comparing the degree of mixing of anticoagulant and blood with
It was recognized that "[+20 degrees] to [-20 degrees]" was optimal.

As shown in FIG. 5, the blood collecting device 10 connects the intake port 17A of the vacuum pump 17 and the vacuum blood collecting chamber 13 with a vacuum pipe 41, and is closed at an intermediate portion of the vacuum pipe 41 by turning on an exhaust solenoid 42. An exhaust valve 43 that is opened by gravity when the exhaust solenoid 42 is turned off is provided. The blood collection device 10 forms a constant negative pressure (vacuum degree) in the vacuum blood collection chamber 13 by controlling the on / off of the vacuum pump 17, and when the blood collection is completed, the exhaust valve 43 is opened to open the vacuum blood collection chamber 13 to the atmosphere.

The blood collection device 10 has an upper part on the front side of the housing 11,
A tube holder 44 is provided in a portion adjacent to the vacuum blood collection chamber 13 so that the blood collection tube 2 connected to the blood bag 1 housed in the vacuum blood collection chamber 13 can be drawn out. Tube holder 44
Is provided with a tube clamp (blood collection stopping means) 46 driven by a tube clamp solenoid 45. The tube clamp 46 closes the blood collection tube 2 by clamping and stops the blood collection operation in the blood bag 1. 47 is a tube clamp 46
Clamp release button, 48 is tube clamp in case of emergency
It is a clamp button that activates 46.

In the blood collection device 10, the connection port (= blood introduction port) of the blood collection tube 2 to the blood bag 1 is positioned at the lowest level of the blood bag 1 when the rocking motor 23 stops rocking. Is set to.

The display panel 12 of the blood sampling device 10 includes a blood sampling amount / vacuum degree switching indicator lamp 49, a blood sampling volume / vacuum degree switching switch 50, 400 ml / 200 m.
l Switching indicator lamp 51, 400ml / 200ml selector switch 52, stop switch 53, start switch 54, back indicator lamp 5 used
5, use bag selector switch 56, blood sampling / vacuum degree display 5
Equipped with 7. The blood collection device 10 includes a power switch 58 and a fuse holder 59 in the lower front portion of the housing 11, and a power connector 60 in the lower rear portion of the housing 11.

Next, the control device 18 of the blood collection device 10 will be described. As shown in FIG. 7, the control device 18 mainly includes a main control circuit 61,
It is composed of a drive circuit 62 and a display circuit 63. Incidentally, 64 is a power supply unit.

The main control circuit 61 includes a CPU (central processing unit) [including a memory in which a control program for a series of operations of the device 10 is written] 65, a memory (storage means) 66, an input / output control unit 67,
It has an LED (light emitting diode) drive circuit 68, a buzzer 69, and a fail-safe circuit 70. The input / output control unit 67 includes the above-mentioned optical sensor for detecting the swing position of the bag tray 19.
40, each detection signal of the blood leak sensor 71 for detecting blood leak from the blood bag 1 is transferred.

The memory 66 is a non-volatile memory such as an EP-ROM or an EEP-ROM, and can rewrite and read the stored data, and can hold the stored data without applying a power supply voltage. The stored data of the memory 66 includes the negative pressure generated in the vacuum blood collection chamber 13, the set blood collection amount in the blood bag 1, the swing extension time of the bag tray 19 after the blood collection is completed, and the like.

The buzzer 69 sounds in different ringing modes depending on the completion of blood collection, the error of the negative pressure formed in the vacuum blood collection chamber 13, the rotation error of the swing motor 23, the blood leak detection of the blood leak sensor 71, and the like.

The fail-safe circuit 70 monitors the occurrence of runaway of the CPU 65 and stops the device on the safe side when the runaway occurs.

The drive circuit 62 is connected to the main control circuit 61, and the A / D
A conversion circuit 72 is provided. The A / D conversion circuit 72 is connected to the weight sensor amplification unit 38 in which the strain gauge 34 is connected, and the pressure sensor 73 that is provided in the vacuum pipe 41 and detects the negative pressure of the vacuum blood collection chamber 13 has a pressure. Sensor amplifier circuit 74
Connected via.

At this time, the CPU 65 of the control device 18 calculates the blood sampling weight by assuming that the output y of the strain gauge 34 constitutes a linear function of y = aw + b with respect to the measured blood sampling weight w. Further, the CPU 65 determines that the output z of the pressure sensor 73 is z = cp + d with respect to the measured pressure p 1
The pressure is calculated as a constituent of the next function.

The drive circuit 62 includes a solenoid drive circuit 75 for controlling the tube clamp solenoid 45 and an exhaust solenoid.
Solenoid drive circuit 76 controlling 42, vacuum pump
A pump drive circuit 78 for turning on / off the power supply switch 77 of 17 and a motor drive circuit 80 for turning on / off the power supply switch 79 of the swing motor 23 are provided.

Incidentally, the CPU 65 of the control device 18 obtains the detected pressure of the pressure sensor 73 and the set pressure of the vacuum blood collection chamber 13 which is the stored data of the memory 66, so that the detected pressure matches the set pressure, and the vacuum is set. The power supply switch 77 of the pump 17 is on / off controlled as described above. As a result, the negative pressure in the vacuum blood collection chamber 13 slightly changes within a fixed range of the set pressure, resulting in a constant pressure state.

Next, a procedure for collecting blood by the blood collecting apparatus 10 will be described.

Turn on the power switch 58.

Select the blood sampling volume with the 400ml / 200ml selector switch 52. The selection result is displayed on the switching display lamp 51.

The bag to be used is selected by using the bag changeover switch 56. The selection result is displayed on the display lamp 55. The types of bags to be used include single (S) having only a parent bag, double (D) having at least one small bag, triple (T), and quadruple (Q).

The blood collecting needle provided at the end of the blood collecting tube 2 is punctured in the donor to collect blood to some extent.

The blood bag 1 is placed in the vacuum blood collection chamber 13 and placed on the bag pan 19, and the blood collection tube 2 is set in the tube holder 44.

The start switch 54 is turned on. Controller 18 is a vacuum pump
17. The swing motor 23 is drive-controlled to collect blood by decompressing the vacuum blood collection chamber 13 and swing the bag tray 19. Further, the control device 18 obtains the output of the weight sensor amplifying unit 38 at the timing as described above when the bag tray 19 is at the turning point of either the highest point or the lowest point in the swinging process, and the blood bag is obtained. The measured blood collection amount of 1 is detected, and the set blood collection amount, the specific gravity of blood, and the blood bag 1 written in the memory 66 are detected.
Using the pre-registered weight of, the remaining blood collection amount (volume) is calculated by the following equation (1).

Residual blood collection amount (ml) = [Set blood collection amount (g) + Pre-registered weight (g) -Measured blood collection amount (g)] / Specific gravity (g / ml) (1) The controller 18 calculates the above calculation result. On the condition that a certain residual blood collection amount has reached zero, the blood collection tube 2 is closed by the tube clamp 46 and the blood collection operation for the blood bag 1 is stopped. At this time, the control device 18 stops the vacuum pump 17 and opens the exhaust valve 43 to open the vacuum blood collection chamber 13 to the atmosphere.

After the blood collection is completed, the controller 18 extends and drives the swing motor 23 for a certain period of time to swing the bag tray 19. After that, the buzzer notifies the end of blood collection.

Turn on the clamp release button 47, remove the blood collection tube 2 from the tube holder 44, and remove the blood bag 1 from the vacuum blood collection chamber 13
Take out from.

In the blood collection device 10, the blood bag 1 is used as a bag tray.
Upper opening 11A of housing 11 for loading and unloading 19
Is set to have a downward slope from the back side of the housing 11 toward the front side.

Next, the operation of the above embodiment will be described.

(1) The rocking stop time for each rocking cycle is made longer at the end stage of blood collection. That is, since the weight measurement accuracy does not have to be so high in the initial stage to the intermediate stage of blood collection, the rocking stop time is set to 0 to a short time so that the anticoagulant and blood are sufficiently stirred. At the end stage of blood collection, in order to improve the accuracy of weight measurement, the rocking stop time is gradually increased so that the weight can be measured in a state where the blood flow in the bag is sufficiently suppressed. As a result, the accuracy of measuring the weight of collected blood can be improved, and the blood can be sufficiently stirred to prevent coagulation.

(2) After the blood collection is completed, the blood bag 1 is further swung for a certain period of time to further sufficiently stir the anticoagulant and blood,
It can prevent solidification more reliably.

(3) The blood collecting weight is measured when the bag tray 19 has the least swinging movement (the turning point above or below the swinging process or in the vicinity thereof), and the shaking occurring in the blood in the blood bag 1 is measured. Accurate weight measurement is possible because the measurement is performed at the minimum timing. Further, since the bag tray 19 is not temporarily stopped in the intermediate process of swinging, the blood bag 1
The anticoagulant inside and blood can be mixed well in the rocking process,
Can prevent blood coagulation.

(4) When the swinging is stopped, the blood introducing port to the blood bag 1 is positioned at the lowest level of the bag 1. As a result, it is possible to prevent the air in the blood bag 1 from accidentally flowing out from the blood introducing port to the donor side.

[Effect of the Invention] As described above, according to the present invention, it is possible to improve the accuracy of measuring the weight of collected blood, and sufficiently stir the blood to prevent coagulation.

[Brief description of drawings]

FIG. 1 is a front view showing a blood collecting device according to one embodiment of the present invention, FIG. 2 is a side view showing a main portion of FIG.
1 is a plan view of FIG. 1, FIG. 4 is a side view showing a scale, FIG. 5 is a vacuum circuit diagram, FIG. 6 is a swinging state diagram, FIG. 7 is a control block diagram, and FIG. ) Is a time-dependent output voltage diagram of the scale at the initial stage of blood collection, FIG. 8 (B) is a time-dependent output voltage diagram of the scale at the end stage of blood collection at a blood sampling amount of 200 ml, and FIG. 8 (C) is FIG. 4 is a time-dependent output voltage diagram of the balance at the blood collection end stage at a blood collection amount of 400 ml. 1 …… Blood bag (blood container), 10 …… Blood collection device, 19 …… Bag saucer (container support), 22 …… Swing frame (swing platform), 23 …… Swing motor, 33 …… Scale (Weight measuring means), 65 ... CPU (control means).

Claims (5)

[Claims] 1. A container support part for supporting a blood container, an oscillating means for oscillating the container support part during blood collection to the blood container, and a weight measurement for measuring the weight of blood collected in the blood container during blood collection. In the blood collecting apparatus having the means, the rocking operation by the rocking means is temporarily performed at every middle rocking cycle of the rocking means at each middle rocking cycle of blood collecting in the blood container. Stop and make the rocking stop time for each rocking cycle longer at the end stage side of blood collection, and further incorporate the measurement result of the weight measuring means within this rocking stop time,
A blood sampling apparatus for measuring a blood sampling weight, comprising control means for determining a blood sampling weight or a blood sampling residual amount in a blood container based on the measurement result. 2. The amount of remaining blood collected in the blood container is equal to the set amount of blood collected.
In the initial stage of 100 to 50%, the swing stop time is 0 to 0.5.
In the intermediate stage, which is 50 to 20%, the rocking stop time is 0.5 to
At the end stage of 1 second, 20% or less, the swing stop time is about 1
The blood collecting device for measuring the blood collecting weight according to claim 1, which is in seconds. 3. The blood sampling apparatus for measuring the blood sampling weight according to claim 1 or 2, wherein the rocking operation by the rocking means is extended for a certain period of time after the blood collection of the set blood collection volume into the blood container is completed. 4. The blood collecting apparatus for measuring the weight of collected blood according to claim 1, wherein the stopping motion of the rocking by the rocking means is performed at a turning point of the rocking process. 5. The blood sampling weight according to claim 1, wherein the blood inlet to the blood container is located at the lowest level of the blood container when the rocking by the rocking means is stopped. Blood sampling device.