HRP20090509T1 - 5-supstituirani derivati kinolina i izokinolina, postupak za njihovu proizvodnju i njihova upotreba kao antiflogistika - Google Patents

5-supstituirani derivati kinolina i izokinolina, postupak za njihovu proizvodnju i njihova upotreba kao antiflogistika Download PDF

Info

Publication number: HRP20090509T1
Authority: HR; Croatia
Prior art keywords: compound; general formula; image; chiral; fluoro
Prior art date: 2004-11-12

Application number

HR20090509T

Other languages

English (en)

Croatian (hr)

Inventor

Jaroch Stefan

Rehwinkel Hartmut

Sch�cke Heike

Schmees Norbert

Skuballa Werner

Schneider Matthias

H�bner Jan

Petrov Orlin

Dinter Christian

Original Assignee

Bayer Schering Pharma Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-12

Filing date

2005-11-11

Publication date

2009-11-30

2005-04-26 Priority claimed from DE102005020331A external-priority patent/DE102005020331A1/de

2005-11-11 Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft

2009-11-30 Publication of HRP20090509T1 publication Critical patent/HRP20090509T1/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HR20090509T 2004-11-12 2005-11-11 5-supstituirani derivati kinolina i izokinolina, postupak za njihovu proizvodnju i njihova upotreba kao antiflogistika HRP20090509T1 (hr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102004055633A DE102004055633A1 (de)	2004-11-12	2004-11-12	5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A DE102005020331A1 (de)	2005-04-26	2005-04-26	5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
PCT/EP2005/012531 WO2006050998A1 (de)	2004-11-12	2005-11-11	5-substituierte chinolin- und isochinolin-derivate; ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Publications (1)

Publication Number	Publication Date
HRP20090509T1 true HRP20090509T1 (hr)	2009-11-30

Family

ID=35613753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20090509T HRP20090509T1 (hr)	2004-11-12	2005-11-11	5-supstituirani derivati kinolina i izokinolina, postupak za njihovu proizvodnju i njihova upotreba kao antiflogistika

Country Status (30)

Country	Link
EP (1)	EP1844039B1 (sr)
JP (1)	JP4460608B2 (sr)
KR (1)	KR101168462B1 (sr)
CN (1)	CN101124220B (sr)
AR (1)	AR051767A1 (sr)
AU (1)	AU2005303926B2 (sr)
BR (1)	BRPI0517797A (sr)
CA (1)	CA2586689C (sr)
CY (1)	CY1110520T1 (sr)
DE (2)	DE102004055633A1 (sr)
DK (1)	DK1844039T3 (sr)
EA (1)	EA013076B1 (sr)
ES (1)	ES2329599T3 (sr)
GT (1)	GT200500330A (sr)
HR (1)	HRP20090509T1 (sr)
IL (1)	IL182933A (sr)
ME (2)	MEP13608A (sr)
MX (1)	MX2007005736A (sr)
MY (1)	MY141780A (sr)
NO (1)	NO332405B1 (sr)
NZ (1)	NZ555064A (sr)
PA (1)	PA8652701A1 (sr)
PE (1)	PE20061052A1 (sr)
PL (1)	PL1844039T3 (sr)
PT (1)	PT1844039E (sr)
RS (2)	RS51161B (sr)
SI (1)	SI1844039T1 (sr)
TW (1)	TWI311559B (sr)
UY (1)	UY29213A1 (sr)
WO (1)	WO2006050998A1 (sr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7402596B2 (en)	2005-03-24	2008-07-22	Renovis, Inc.	Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI464148B (zh)	2006-03-16	2014-12-11	Evotec Us Inc	作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
CN101484187B (zh) *	2006-07-07	2012-12-26	博士伦公司	包含解离的糖皮质激素受体激动剂和免疫抑制剂的用于治疗干眼症的组合物
BRPI0714815A2 (pt) *	2006-08-07	2013-05-21	Bausch & Lomb	composiÇço, e, uso de um (a) agonista e (b) um agente anti-infeccioso
ATE531366T1 (de) *	2006-08-07	2011-11-15	Bausch & Lomb	Zusammensetzungen und verfahren zur behandlung, verminderung, verbesserung oder linderung von erkrankungen des hinteren augensegments
EP2397140A1 (en) *	2006-08-31	2011-12-21	Bausch & Lomb Incorporated	Compositions and methods for treating or preventing glaucoma or progression thereof
US20110105559A1 (en) *	2006-09-11	2011-05-05	Rohrs Brian R	Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy
US20110104159A1 (en) *	2006-09-11	2011-05-05	Rohrs Brian R	Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
DK2061444T3 (da) *	2006-09-11	2011-06-27	Bausch & Lomb	Sammensætninger og fremgangsmåder til behandling, kontrol, reducering, forbedring eller forebyggelse af allergi
KR20090077946A (ko) *	2006-11-09	2009-07-16	보오슈 앤드 롬 인코포레이팃드	특정 치환된 알코올의 선택된 입체이성질체의 합성
EP1982976A1 (en) *	2007-04-18	2008-10-22	Intendis GmbH	Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof
KR20090129480A (ko) *	2007-04-18	2009-12-16	인텐디스 게엠베하	비스테로이드성 항염증제의 제조 방법 및 그의 중간체
EP2016935A1 (en) *	2007-07-09	2009-01-21	Intendis GmbH	Pharmaceutical composition for topical application of poorly soluble compounds
US20090042936A1 (en) *	2007-08-10	2009-02-12	Ward Keith W	Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20090087443A1 (en) *	2007-09-27	2009-04-02	Bartels Stephen P	Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery
CA2702761A1 (en) *	2007-11-01	2009-05-07	Bausch & Lomb Incorporated	Non-aqueous water-miscible materials as vehicles for drug delivery
US20110077270A1 (en) *	2009-04-21	2011-03-31	Pfeffer Bruce A	Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
CN101983961B (zh) *	2010-11-24	2012-05-09	浙江启明生化科技有限公司	5-氨基-2-甲基喹啉的制备方法
US20120316199A1 (en)	2011-06-07	2012-12-13	Ward Keith W	Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
WO2017137375A1 (en)	2016-02-12	2017-08-17	Bayer Animal Health Gmbh	Mapracorat for use in the treatment of canine dermatitis
CN111646908B (zh) *	2017-01-16	2023-03-10	宜昌尚诺德生物医药科技有限公司	一种制备芳胺化合物的方法
CA3123490A1 (en)	2019-01-22	2020-07-30	Akribes Biomedical Gmbh	Selective glucocorticoid receptor modifiers for treating impaired skin wound healing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4041482A1 (de) *	1990-12-22	1992-06-25	Boehringer Ingelheim Kg	Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine
NO940245D0 (no) *	1993-01-28	1994-01-24	Takeda Chemical Industries Ltd	Quinolin eller quinazolinderivater, deres fremstilling og anvendelse
RU2127271C1 (ru) *	1997-03-13	1999-03-10	Пермская государственная фармацевтическая академия	5-нитрофурфурилиденгидразид 2-хлор-5,6,7,8,-тетрагидрохинолин-4-карбоновой кислоты, обладающий антимикробной активностью
UA73492C2 (en) *	1999-01-19	2005-08-15		Aromatic heterocyclic compounds as antiinflammatory agents
DE10215316C1 (de) *	2002-04-02	2003-12-18	Schering Ag	Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
CA2512257A1 (en) *	2003-01-03	2004-07-29	Boehringer Ingelheim Pharmaceuticals, Inc.	1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20040224992A1 (en) *	2003-02-27	2004-11-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7179919B2 (en) *	2004-03-18	2007-02-20	Boehringer Ingelheim Pharmaceuticals, Inc.	Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

2004
- 2004-11-12 DE DE102004055633A patent/DE102004055633A1/de not_active Ceased
2005
- 2005-11-11 DK DK05808294T patent/DK1844039T3/da active
- 2005-11-11 TW TW094139706A patent/TWI311559B/zh not_active IP Right Cessation
- 2005-11-11 CN CN2005800464522A patent/CN101124220B/zh not_active Expired - Fee Related
- 2005-11-11 GT GT200500330A patent/GT200500330A/es unknown
- 2005-11-11 SI SI200530792T patent/SI1844039T1/sl unknown
- 2005-11-11 RS RSP-2009/0367A patent/RS51161B/sr unknown
- 2005-11-11 ME MEP-136/08A patent/MEP13608A/xx unknown
- 2005-11-11 NZ NZ555064A patent/NZ555064A/en not_active IP Right Cessation
- 2005-11-11 PT PT05808294T patent/PT1844039E/pt unknown
- 2005-11-11 MY MYPI20055308A patent/MY141780A/en unknown
- 2005-11-11 JP JP2007540615A patent/JP4460608B2/ja not_active Expired - Fee Related
- 2005-11-11 EP EP05808294A patent/EP1844039B1/de not_active Expired - Lifetime
- 2005-11-11 AU AU2005303926A patent/AU2005303926B2/en not_active Ceased
- 2005-11-11 DE DE502005007725T patent/DE502005007725D1/de not_active Expired - Lifetime
- 2005-11-11 PL PL05808294T patent/PL1844039T3/pl unknown
- 2005-11-11 WO PCT/EP2005/012531 patent/WO2006050998A1/de not_active Ceased
- 2005-11-11 CA CA2586689A patent/CA2586689C/en not_active Expired - Fee Related
- 2005-11-11 ME MEP-2008-136A patent/ME00155B/me unknown
- 2005-11-11 BR BRPI0517797-9A patent/BRPI0517797A/pt not_active IP Right Cessation
- 2005-11-11 MX MX2007005736A patent/MX2007005736A/es active IP Right Grant
- 2005-11-11 HR HR20090509T patent/HRP20090509T1/hr unknown
- 2005-11-11 ES ES05808294T patent/ES2329599T3/es not_active Expired - Lifetime
- 2005-11-11 RS RSP-2007/0205A patent/RS20070205A/sr unknown
- 2005-11-11 KR KR1020077010785A patent/KR101168462B1/ko not_active Expired - Fee Related
- 2005-11-11 EA EA200700982A patent/EA013076B1/ru not_active IP Right Cessation
- 2005-11-14 UY UY29213A patent/UY29213A1/es not_active Application Discontinuation
- 2005-11-14 PA PA20058652701A patent/PA8652701A1/es unknown
- 2005-11-14 AR ARP050104767A patent/AR051767A1/es not_active Application Discontinuation
- 2005-11-14 PE PE2005001324A patent/PE20061052A1/es not_active Application Discontinuation
2007
- 2007-05-02 IL IL182933A patent/IL182933A/en not_active IP Right Cessation
- 2007-06-11 NO NO20072963A patent/NO332405B1/no not_active IP Right Cessation
2009
- 2009-10-15 CY CY20091101074T patent/CY1110520T1/el unknown

Also Published As

Publication number	Publication date
MY141780A (en)	2010-06-30
MX2007005736A (es)	2007-09-07
WO2006050998A1 (de)	2006-05-18
CN101124220A (zh)	2008-02-13
RS20070205A (sr)	2008-11-28
EA200700982A1 (ru)	2007-10-26
TW200640913A (en)	2006-12-01
KR20070084192A (ko)	2007-08-24
EP1844039A1 (de)	2007-10-17
AU2005303926B2 (en)	2011-05-19
PL1844039T3 (pl)	2009-12-31
AR051767A1 (es)	2007-02-07
BRPI0517797A (pt)	2008-10-21
PE20061052A1 (es)	2006-11-08
RS51161B (sr)	2010-10-31
CY1110520T1 (el)	2015-04-29
EA013076B1 (ru)	2010-02-26
EP1844039B1 (de)	2009-07-15
MEP13608A (en)	2010-06-10
PT1844039E (pt)	2009-10-19
GT200500330A (es)	2006-09-21
DE102004055633A1 (de)	2006-05-18
DE502005007725D1 (de)	2009-08-27
IL182933A (en)	2011-10-31
NO332405B1 (no)	2012-09-10
NZ555064A (en)	2009-09-25
SI1844039T1 (sl)	2009-12-31
NO20072963L (no)	2007-08-03
CA2586689A1 (en)	2006-05-18
IL182933A0 (en)	2007-09-20
ME00155B (me)	2010-10-10
JP4460608B2 (ja)	2010-05-12
HK1112243A1 (en)	2008-08-29
AU2005303926A1 (en)	2006-05-18
ES2329599T3 (es)	2009-11-27
JP2008519803A (ja)	2008-06-12
DK1844039T3 (da)	2009-11-09
CA2586689C (en)	2012-04-17
KR101168462B1 (ko)	2012-07-27
CN101124220B (zh)	2012-04-25
TWI311559B (en)	2009-07-01
UY29213A1 (es)	2006-05-31
PA8652701A1 (es)	2006-07-03

Publication	Publication Date	Title
HRP20090509T1 (hr)	2009-11-30	5-supstituirani derivati kinolina i izokinolina, postupak za njihovu proizvodnju i njihova upotreba kao antiflogistika
US5096914A (en)	1992-03-17	Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
CN108395452B (zh)	2021-08-03	作为钠通道调节剂的吡啶酮酰胺的前药
US7008950B1 (en)	2006-03-07	Benzofurans as suppressors of neurodegeneration
EP1490361B1 (en)	2007-10-03	Polycyclic compounds as potent alpha2-adrenoceptor antagonists
ZA200403713B (en)	2005-10-26	Acetylene derivatives having mglur 5 antagonistic activity
Singh et al.	2004	Synthesis and antimalarial activity of a new series of trioxaquines
JP5513515B2 (ja)	2014-06-04	アリールピペラジンおよびアルファ２ｃアンタゴニストとしてのそれらの使用
KR102250214B1 (ko)	2021-05-07	1-인단설파미드 유도체를 포함하는 통증에 대한 치료제 및/또는 예방제
JP2016164168A (ja)	2016-09-08	ホスホジエステラーゼ阻害剤としてのベンゾジオキソールまたはベンゾジオキセピンヘテロ環化合物
AU2004260758A1 (en)	2005-02-10	Phenylazole compounds, production process, and antioxidants
JP2879147B2 (ja)	1999-04-05	新規な抗高血圧性ベンゾピラン誘導体
RU2005131172A (ru)	2006-05-10	Производные хинолионона/бензоксазинона и их применение
IL104386A (en)	2001-05-20	Derivatives of benzopyran, chromane, naphthalene, indan and related compounds which are ltb4 antagonists and pharmaceutical compositions containing them
AU2007258506A1 (en)	2007-12-21	6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
MC1600A1 (fr)	1985-05-09	Nouveaux derives de pyrimidone
EP1192152B1 (fr)	2002-11-27	Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
US4446148A (en)	1984-05-01	Benzodioxanyl imidazoline compounds, compositions and use
ZA200505110B (en)	2006-03-29	Optically active dihydropyridine derivative
US4810712A (en)	1989-03-07	Bicyclic lactams, processes for their use, and formulations containing these compounds
KR20160149561A (ko)	2016-12-28	5-ht7 수용체에 작용하는 바이페닐 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 약학조성물
JP2001512491A (ja)	2001-08-21	１−（イソキノリン−１−イル）−４−（１−フェニメチル）ピペラジン；ドーパミン受容体サブタイプ特異的リガンド
CA2628014A1 (en)	2007-05-10	Ortho-substituted aniline derivative and antioxidant drug
KR100472522B1 (ko)	2005-03-07	스피로 이미다졸린 화합물, 이것의 제조방법 및 이것을 함유하는 약제학적 조성물
JP2928288B2 (ja)	1999-08-03	ピロリジン誘導体