JPS6133004B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a dentifrice composition, and more particularly, to a dentifrice composition that has improved foaming properties when using a safer acyl glutamate as a foaming agent, and does not change the taste of food after tooth brushing. . Toothpaste compositions contain foaming agents to impart cleaning, dispersing, emulsifying, and foaming effects.
Surfactants are used for that purpose. Surfactants used as foaming agents increase the cleaning effect of toothpaste by lowering the interfacial tension of the toothpaste during use, promote the dispersion and penetration of the medicinal agents contained in the toothpaste, and increase its effectiveness. It can be said to be an essential ingredient as it plays the role of providing a sense of stability through foaming during use. These surfactants must not only have good performance such as interfacial tension lowering ability and foaming properties, but also satisfy aspects such as taste and odor since toothpaste is something that is put in the mouth. Conventionally, anionic surfactants such as sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate, and sodium coconut monoglyceride sulfate have been used, and sodium alkyl sulfate in particular has excellent performance and taste, but is not commonly used. However, it has the major disadvantage that it changes the taste of food after use, which is thought to be caused by adsorption to the taste buds of the tongue and oral mucosa.
There are problems such as slight irritation of the oral mucosa and inactivation of enzymes added as medicinal agents in toothpaste. On the other hand, recently, the safety of these surfactants has become a problem, and various studies have been conducted to use safer surfactants as foaming agents.
As one of these, it has been proposed to incorporate acylglutamate into toothpaste (Special Publication No. 45-24480).
issue). Acyl glutamate is non-toxic, has extremely mild irritation to the skin and mucous membranes, has good cleaning power, foaming power, emulsifying power, and has excellent hard water resistance. It is very useful as a foaming agent for dentifrice compositions. However, when this is added to a dentifrice composition, it is affected by the base that releases polyvalent cations, such as calcium phosphate and calcium carbonate, which are usually included in the dentifrice composition, resulting in a phenomenon in which the foaming power is extremely reduced. In fact, it is very difficult to incorporate it into such dentifrice compositions. In view of the current situation, the present inventors have developed a foaming agent that releases polyvalent cations such as calcium phosphate or calcium carbonate as a base and an acyl foaming agent as a foaming agent. As a result of various studies on the foaming properties of dentifrice compositions containing glutamate, it was discovered that the foaming properties were significantly improved by the combined use of sodium monofluorophosphate and/or polyphosphate, and the present invention was completed. I arrived. That is, the present invention is characterized in that sodium monofluorophosphate and/or polyphosphate is blended into a dentifrice composition containing a base that releases polyvalent cations and an acylglutamate as a foaming agent. The dentifrice composition of the present invention has excellent foaming properties and does not change the taste of food after brushing unlike conventional dentifrice compositions containing sodium alkyl sulfate. It is highly safe and has an anti-caries effect due to the inclusion of sodium monofluorophosphate. Table 1 below shows the results of testing the effects of adding sodium monofluorophosphate and polyphosphate. In the test, a monosodium salt in which the acyl group is a hydrogenated tallow fatty acid residue (14 to 18 carbon atoms) was used as the acyl glutamate, and according to the composition of the example below,
Dentifrice compositions containing various amounts of sodium monofluorophosphate, insoluble sodium metaphosphate, and sodium pyrophosphate were diluted to 1/10 with water,
The foam height (cm) after 1 minute was measured by the Rosmailes method and was defined as the foaming amount. The volume was evaluated as follows. ◎: Sufficient foaming 〇: Foaming △: Little foaming ×: Almost no foaming

[Table] As is clear from Table 1, when no sodium monofluorophosphate, insoluble sodium metaphosphate or sodium pyrophosphate was added, the amount of foaming was very low, but with the addition of these, foaming properties were significantly improved. I understand that. Therefore, according to the present invention, sodium monofluorophosphate and polyphosphate are used alone or in combination in a dentifrice composition containing an acylglutamate and a base that releases polyvalent cations such as calcium phosphate or calcium carbonate. and mix. The blending amount of these sodium monofluorophosphate is 1.1% (weight%, the same applies hereinafter) or less, preferably 0.15 to 0.74% (200 to 200% as fluorine).
1000ppm) and polyphosphate from 0.5 to 3%. Examples of the polyphosphates used include pyrophosphoric acid, tripolyphosphoric acid, tetrametaphosphoric acid, hexametaphosphoric acid, alkali metal salts such as sodium and potassium salts of insoluble metaphosphoric acid, and ammonium salts, and these may be used alone or in mixtures. When a salt is blended, it is preferable to use calcium phosphate as the base for releasing the polyvalent cation. The acyl glutamate to be used is preferably a monosodium salt of beef tallow fatty acid residue (carbon 14-18) having an acyl group since it has good foaming properties. The foaming property in an aqueous solution is highest when the acyl group is a lauric acid residue, but the foaming property is low in the dentifrice composition. The blending ratio of the acyl glutamate is appropriately selected depending on the formulation of the dentifrice composition, but is usually preferably in the range of 1 to 3%. The dentifrice composition of the present invention includes all conventionally effective dentifrice compositions such as toothpaste, toothpaste, dentifrice ointment, and water dentifrice. In addition, other ingredients may be those normally used in dentifrice compositions, such as sodium carboxymethyl cellulose, carginan, sodium alginate, bentonite as a binder,
Glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol, etc. are used as wetting agents such as silicic anhydride. In addition, various medicinal agents may be added to the dentifrice composition of the present invention, and such medicinal agents include aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, salt, tranexamic acid, ε−
Examples include aminocaproic acid. According to the present invention, as described above, it is possible to obtain a dentifrice composition that contains a foaming agent with higher safety, has extremely good foaming properties, and does not change the taste of food after use. Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto. Example 1 A toothpaste was prepared according to a conventional method using the following formulation. Ingredients % Calcium carbonate 40.00 Carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 13.00 Sorbitol 7.00 Silicic anhydride 1.50 Water 33.66 Sodium acylglutamate (manufactured by Ajinomoto Co., Inc., Amisoft HS-11, acyl group: hardened tallow fatty acid residue with 14 to 18 carbon atoms) ) 2.00 Bactericide, preservative 0.10 Sodium monofluorophosphate 0.74 Flavoring agent 1.00 Example 2 A toothpaste was prepared according to the conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 45.00 Carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 30.06 Sodium acylglutamate (Ajinomoto Co., Inc., Amisoft HS-11) 2.00 Satucalin sodium 0.10 Bactericide, preservative 0.10 Monofluoro Sodium phosphate 0.74 Flavor 1.00 Example 3 A toothpaste was prepared according to the following recipe according to a conventional method. Component percentage calcium second phosphate, two hydrogen, 43.00 carboximethylcellulose 0.50 karaginan 0.50 glycerin 10.00 sorbitol 10.00 water 30.80 Asylgurtamate sodium Asylglutamate (Ami no Moto Co., Ltd., Amizomi Co., Ltd.) 2.00 Satsukarin Natrium 0.10 Satsukarin Natrium. Assembly, preservative 0.10 insoluble metalin Sodium acid 2.00 Flavor 1.00 Using the dentifrice composition of Example 2, the "orange youth effect" (after using dentifrice, the effect of
A representative example of this was the phenomenon in which the taste of orange juice changes significantly when drinking it (Special Publication No. 47-43830). The test used a composition (reference example) in which sodium acylglutamate was replaced with sodium lauryl sulfate (2%) in the composition of Example 2 as a control, and a panel of five experts evaluated the flavor of orange juice drunk after using toothpaste. The evaluation was made as follows. 0: No change in flavor, 1: Almost no change in flavor,
2: The flavor changes slightly; 3: The flavor changes considerably; 4: The flavor changes significantly. The results are shown in Table 2 below.

[Table] As is clear from Table 2, the dentifrice composition of the present invention hardly changes the flavor of food after use. Example 4 Similar to the above example, a toothpaste was prepared according to the following recipe according to the conventional method. Ingredients % Dicalcium phosphate dihydrate 45.00 Carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 7.00 Sodium acylglutamate (Ajinomoto Co., Inc., Amisoft HS-11) 2.00 Satucalin sodium 0.10 Bactericide, preservative 0.10 Monofluorophosphoric acid Sodium Table 3 Labeled amount Sodium pyrophosphate Table 3 Labeled amount Fragrance 1.00 Water Adjusted to 100% The resulting toothpaste was tested for foaming amount and volume in the same manner as above. The results are also shown in Table 3.

[Table] As shown in Table 3, the dentifrice composition of the present invention has significantly improved foaming properties. The orange juice effect of these toothpastes was tested in the same manner as above, but none of the panel members found that the flavor of orange juice changed. Example 5 Similar to the previous example, a toothpaste was prepared according to the conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 43.00 Carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Sodium acylglutamate (Ajinomoto Co., Inc., Amisoft HS-11) 2.00 Satucalin sodium 0.10 Bactericide, preservative 0.10 Monofluorophosphoric acid Sodium Table 4 Labeled amount Insoluble sodium metaphosphate Table 4 Labeled amount Fragrance 1.00 Water Adjusted to 100% The resulting toothpaste was tested for foaming amount and volume in the same manner as above. The results are also shown in Table 4.

[Table] As shown in Table 4, the dentifrice composition of the present invention exhibits significantly improved foaming properties. In addition, although the orange juice effect was similarly tested, none of the panel members found that the flavor changed.

Claims (1)

[Claims] 1. A dentifrice composition without sodium alkyl sulfate containing acylglutamic acid monosodium salt whose acyl group is a hydrogenated beef tallow fatty acid residue having 14 to 18 carbon atoms as a calcium ion-releasing base and a foaming agent. 0.74% by weight sodium monofluorophosphate and/or 0.5-3% by weight
A toothpaste composition characterized in that it contains a polyphosphate.