Large-Scale Simultaneous Hypothesis Testing: The Choice of a Null Hypothesis Bradley EFRON Curren... Large-Scale Simultaneous Hypothesis Testing: The Choice of a Null Hypothesis Bradley EFRON Current scienti� c techniques in genomics and image processing routinely produce hypothesis testing problems with hundreds or thousands of cases to consider simultaneously. This poses new dif� culties for the statistician, but also opens new opportunities. In particular, it allows empirical estimation of an
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